When I first read the 2022 Nature paper on the risks of COVID-19 reinfection, I thought it was a solid, well-constructed study. They analyzed outcomes across nearly 5.8 million U.S. veterans and concluded that reinfection carried added risks—hospitalization, long-term organ damage, and death—regardless of vaccination status.
That statement is true. But I’ve come to realize it may not be the truth.
Because buried in the details of that paper was something I initially missed. And now that I’ve seen it, I can’t unsee it.
The Question We Forgot to Ask
Since 2020, my work has focused on autoimmunity and how SARS-CoV-2 may trigger immune responses that turn on the body, particularly via ACE2, the very receptor the virus uses to enter cells. I proposed early on that when free-floating ACE2 binds to the viral spike in circulation, it could prime the immune system to attack ACE2-rich organs: the lungs, heart, kidneys, and brain.
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Now, let’s forget the autoimmunity hypothesis for a moment and just stick with what’s widely accepted: in severe COVID-19, the immune system is the problem, not the virus. The cytokine storm causes the immune system going into overdrive which kills people, not the viral load itself.
So here’s the basic question that should have shaped the pandemic response:
Should you further stimulate the immune system with vaccines after someone has already had moderate to severe COVID-19?
Thursday 26th June, 2025 at 7PM UK time
The Data Speaks — But Not Loud Enough
The study looked at three groups: those with no vaccines, those with one vaccine, and those with two or more. Each group had been infected, recovered, and then reinfected. All had a chance to demonstrate immunity. But what happened after that second infection?
The all-cause mortality risk was higher in the vaccinated groups, not the unvaccinated. Let me repeat that: after reinfection, people with one or two+ COVID-19 vaccinations had a higher risk of dying from any cause than those who were never vaccinated.
Even hospitalization risk slightly favored the unvaccinated. And the most striking detail? The elevated mortality in the vaccinated group did not coincide with higher hospitalization. That implies something sudden, like cardiac arrest, embolism, or stroke—events that kill people before they ever reach the hospital.
This is what we’ve been warning about. Sudden, unexpected deaths. And it was in the dataset all along.
What Should Have Happened in 2022
If this pattern had been recognized when the study was published, it should have immediately triggered autopsy investigations on vaccinated individuals who died after reinfection. Were their deaths immunological in nature? Were there clots? Cardiac inflammation? Brainstem involvement?
But no wave of investigation came. Instead, booster campaigns continued, even targeting those most at risk: older adults who had already survived severe COVID—the very group now shown to have the highest risk of dying upon reinfection after vaccination.
What This Means Going Forward
We need to stop pretending that more immune stimulation is always better. If someone had measles, we wouldn’t vaccinate them for measles the next month. Why should it be different for COVID-19, especially when severe disease is driven by immune dysregulation?
We must now ask:
Are patients who survived moderate to severe COVID being put at risk by ongoing booster recommendations?
Is the immune system in these individuals being pushed toward a delayed but deadly overreaction?
And most urgently—why aren’t autopsies being done to find out?
This isn’t just a scientific oversight. It’s a public health failure.
I will continue to push for answers. Because if even a fraction of the deaths we’re seeing now are preventable, we have a moral obligation to act—not later, but now.
Stay sharp. Stay critical. And stay compassionate.
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