I have experienced what I believe to be an example of this. I had a fellow working for me at the start of covid. He was bright and did good work. (Drafting technologist.) He was 60 at the time, very fit, running every day. At the time we had our differences about the vaccines and he insisted they were beneficial. He only worked for me for a month, on contract, before being offered a full-time job elsewhere.
Fast-forward to 6 months ago. I rehired him as he left his last position. We talked a bit about the pandemic and he said he was up to date on his boosters. (Probably 5 or 6, I didn't ask.) He was a completely different person. He made the strangest mistakes, like he was very drunk or high, even though he wasn't. He couldn't remember the simplest instructions or processes. He quit after about a month, saying he was going to retire early.
I can't be certain, but I think that his mental deterioration was due to the vaccines and/or his constant mask wearing. Very sad. I didn't talk to him again.
The gut microbiome plays a crucial role in various physiological functions of the host, including gastrointestinal function, metabolism, immune homeostasis, neuroactivity, and behavior.
The microbiome interacts bidirectionally with the immune system, and disruptions in this communication can lead to immune dysfunction and immune-mediated conditions in distant organs, including the brain.
In this review, the authors discuss recent evidence that supports the role of the gut microbiome in modulating the neuroimmune landscape in health and disease.
🔷️ The human gut microbiota is a complex, dynamic, and highly diverse community of microorganisms.
.
🔷️ Beginning as early as in utero fetal development and continuing through birth to late-stage adulthood, the crosstalk between the gut microbiome and brain is essential for modulating various metabolic, neurodevelopmental, and immune-related pathways.
.
🔷️ Conversely, microbial dysbiosis - defined as alterations in richness and relative abundance - of the gut is implicated in the pathogenesis of several chronic neurological and neurodegenerative disorders.
.
🔷️ Individuals with neurodegenerative conditions have an altered gut microbial composition as well as microbial and serum metabolomic profiles distinct from those in the healthy population.
.
🔷️ Dysbiosis is also linked to psychiatric and gastrointestinal complications - comorbidities often associated with the prodromal phase of Parkinson's disease (PD) and Alzheimer's disease (AD).
.
Studies have identified potential mediators that link gut dysbiosis and neurological disorders. Recent findings have also elucidated the potential mechanisms of disease pathology in the enteric nervous system prior to the onset of neurodegeneration.
.
🔷️ This review highlights the functional pathways and mechanisms, particularly gut microbe-induced chronic inflammation, protein misfolding, propagation of disease-specific pathology, defective protein clearance, and autoimmune dysregulation, linking gut microbial dysbiosis and neurodegeneration.
.
🔷️ In addition, pathogenic transformation of microbial composition leads to increased endotoxin production and fewer beneficial metabolites, both of which could trigger immune cell activation and enteric neuronal dysfunction.
.
🔷️ These can further disrupt intestinal barrier permeability, aggravate the systemic pro-inflammatory state, impair blood-brain barrier permeability and recruit immune mediators leading to neuroinflammation and neurodegeneration.
.
🔷️ Continued biomedical advances in understanding the microbiota-gut-brain axis will extend the frontier of neurodegenerative disorders and enable the utilization of novel diagnostic and therapeutic strategies to mitigate the pathological burden of these diseases.
Your diagram showed one mechanism for microclots in a capillary. If i recall correctly you have previously shown other mechanisms how spikes can affect both hemoglobin and endothelial cells directly, causing clots or slipping through the endothelium to the next layer of cells. So there are multiple ways spikes can lead to dementia.
I have experienced what I believe to be an example of this. I had a fellow working for me at the start of covid. He was bright and did good work. (Drafting technologist.) He was 60 at the time, very fit, running every day. At the time we had our differences about the vaccines and he insisted they were beneficial. He only worked for me for a month, on contract, before being offered a full-time job elsewhere.
Fast-forward to 6 months ago. I rehired him as he left his last position. We talked a bit about the pandemic and he said he was up to date on his boosters. (Probably 5 or 6, I didn't ask.) He was a completely different person. He made the strangest mistakes, like he was very drunk or high, even though he wasn't. He couldn't remember the simplest instructions or processes. He quit after about a month, saying he was going to retire early.
I can't be certain, but I think that his mental deterioration was due to the vaccines and/or his constant mask wearing. Very sad. I didn't talk to him again.
If it were "constant mask wearing" .... then SURGEONS WOULD have severe mental deterioration too.
Thanks Dr Philip Mc Millan, thought you might like Frank and Maryam..
The Gut Microbiome as a Regulator of the Neuroimmune Landscape
.
Aʟᴢʜᴇɪᴍᴇʀ Exᴘᴇʀᴛ & Bʀᴀɪɴ Mɪᴄʀᴏʙɪᴏᴍᴇ Exᴘᴇʀᴛ
.
Frank Bernier, PhD, MSc, CIP
https://www.linkedin.com/posts/francois-bernier-phd_mdabrimmunol-immunolog-microbiome-activity-7041659722030071808-sOzL
The gut microbiome plays a crucial role in various physiological functions of the host, including gastrointestinal function, metabolism, immune homeostasis, neuroactivity, and behavior.
The microbiome interacts bidirectionally with the immune system, and disruptions in this communication can lead to immune dysfunction and immune-mediated conditions in distant organs, including the brain.
In this review, the authors discuss recent evidence that supports the role of the gut microbiome in modulating the neuroimmune landscape in health and disease.
Thanks, Maryam, for finding that excellent paper!
#microbiome #neuroscience #gutbrainaxis #neurology
.
⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️⬇️
.
Immunologist at Tehran University of Medical Sciences
.
MARYAM DIBA
https://www.linkedin.com/posts/maryam-diba-961420214_mdabrimmunol-immunolog-microbiome-activity-7041651916375785473-7Pjp
Follow for more 👉 #MD_Immunol
The Gut Microbiome as a Regulator of the Neuroimmune Landscape
https://www.annualreviews.org/doi/abs/10.1146/annurev-immunol-101320-014237
PDF ⬇️
https://www.annualreviews.org/doi/pdf/10.1146/annurev-immunol-101320-014237
🔷️ The human gut microbiota is a complex, dynamic, and highly diverse community of microorganisms.
.
🔷️ Beginning as early as in utero fetal development and continuing through birth to late-stage adulthood, the crosstalk between the gut microbiome and brain is essential for modulating various metabolic, neurodevelopmental, and immune-related pathways.
.
🔷️ Conversely, microbial dysbiosis - defined as alterations in richness and relative abundance - of the gut is implicated in the pathogenesis of several chronic neurological and neurodegenerative disorders.
.
🔷️ Individuals with neurodegenerative conditions have an altered gut microbial composition as well as microbial and serum metabolomic profiles distinct from those in the healthy population.
.
🔷️ Dysbiosis is also linked to psychiatric and gastrointestinal complications - comorbidities often associated with the prodromal phase of Parkinson's disease (PD) and Alzheimer's disease (AD).
.
Studies have identified potential mediators that link gut dysbiosis and neurological disorders. Recent findings have also elucidated the potential mechanisms of disease pathology in the enteric nervous system prior to the onset of neurodegeneration.
.
🔷️ This review highlights the functional pathways and mechanisms, particularly gut microbe-induced chronic inflammation, protein misfolding, propagation of disease-specific pathology, defective protein clearance, and autoimmune dysregulation, linking gut microbial dysbiosis and neurodegeneration.
.
🔷️ In addition, pathogenic transformation of microbial composition leads to increased endotoxin production and fewer beneficial metabolites, both of which could trigger immune cell activation and enteric neuronal dysfunction.
.
🔷️ These can further disrupt intestinal barrier permeability, aggravate the systemic pro-inflammatory state, impair blood-brain barrier permeability and recruit immune mediators leading to neuroinflammation and neurodegeneration.
.
🔷️ Continued biomedical advances in understanding the microbiota-gut-brain axis will extend the frontier of neurodegenerative disorders and enable the utilization of novel diagnostic and therapeutic strategies to mitigate the pathological burden of these diseases.
#immunolog #microbiome #neuroimmune #microglia #microbiota #brain #neuroinflammation
Your diagram showed one mechanism for microclots in a capillary. If i recall correctly you have previously shown other mechanisms how spikes can affect both hemoglobin and endothelial cells directly, causing clots or slipping through the endothelium to the next layer of cells. So there are multiple ways spikes can lead to dementia.