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Absolutely – ACE2 dysregulation is a cause of severity of Covid-19. Once bound to S protein ACE2 is not able to fulfil its main function in renin angiotensin system (RAS) – regulation of blood pressure and inflammatory processes. ACE2 is more abundant and with lower affinity in children, therefore, SC2 infection may not cause significant dysregulation or the RAS. In old adults and seniors expression of AC2 on cell surfaces is less evident but with higher affinity, therefore, anything binding to ACE2 decreased number of functioning ACE2 that leads to increased risk of myocardial fibrosis, inflammation and cardiovascular disease.

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due to 5X increase in ace 2 from ace and arb drugs?

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