Dr. McMillan, if I'm not mistaken, people with von Willebrand disease (vWD), including those with factors 2 and 5 deficiencies, also need to be cautious with supplements like Omega-3. Omega-3 fatty acids can have blood-thinning effects, which might increase bleeding risk, particularly in individuals with clotting disorders such as von Willebrand disease.
I'm particularly concerned about those who may be unaware.
Several friends, aged 40 to 70, were never tested for VWD until I brought it up. Recently, tests revealed that 9 out of 11 had at least one variant of vWF.
I wonder if some of the blood thinners or others such as statins and arthritis drugs that older people are commonly prescribed might be causing this VWD. Also how does it differ from haemophilia?
I have VWD and have been researching it for years as new papers become available.
Von Willebrand Disease (VWD) is a genetic bleeding disorder caused by a deficiency or dysfunction of von Willebrand factor (VWF)
VWD is caused by a deficiency or dysfunction of von Willebrand factor. Hemophilia, on the other hand, is usually caused by a deficiency of clotting factor VIII (in Hemophilia A) or factor IX (in Hemophilia B).
There’s no direct evidence that statins cause VWD, but they can have some effects on platelets and the clotting system,
Nonsteroidal on the other hand, anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen can inhibit platelet function, which may exacerbate bleeding in people with VWD. NSAIDs can cause gastrointestinal bleeding as well, adding to the bleeding risks in these patients.
Here are some references to the information provided:
Von Willebrand Disease (VWD) Overview:
National Hemophilia Foundation. (n.d.). What is von Willebrand Disease?
Differences Between VWD and Hemophilia:
Mayo Clinic. (2023). Von Willebrand disease.
National Heart, Lung, and Blood Institute (NHLBI). (2022). Hemophilia.
Effect of Blood Thinners on Bleeding Disorders:
American Heart Association. (2015). What You Should Know About Blood Thinners.
U.S. National Library of Medicine. (2023). Anticoagulants.
Statins and Bleeding Risks:
British Journal of Clinical Pharmacology. (2017). Statins and risk of hemorrhagic stroke: Systematic review and meta-analysis.
MedlinePlus. (2023). Statins.
NSAIDs and Bleeding Risks:
Cleveland Clinic. (2021). The Dangers of Mixing Blood Thinners and NSAIDs.
American College of Rheumatology. (2023). Nonsteroidal Anti-Inflammatory Drugs (NSAIDs).
Good information and advice 👍🏻👍🏻 it is clear such supplements should not be taken without one’s doctor’s recommendation and the doctor himself should be aware of this scenario.
My first job, here in India, 45 years ago, was in vegetable oil R&D, mainly edible types, but industrial uses also. Though I had ample exposure to their industrial applications in my subsequent jobs, I have maintained very close reading touch with the edible oils, till this day, well into my long retirement. One of my top favourite subjects. For vegetarians, a large population in India, w-3 (ALA) is out of reach. In the plant kingdom, only Flaxseed, Perilla, Camelina, & Hempseed contain more than 25% of ALA, these are not everyday oils. Mustard ( a favourite in north India and Soybean ( used here in some blended oils) contain single digit levels of w-3. It is also said that plant based w-3 need to be converted into the marine type by the body for effectiveness and this process is not very efficient. So much so, we vegetarians have evolved to make do without w-3, for all practical purposes. So, for us, the major criterion is now only maximising oleic content. Fortunately, our traditional oils like ground nut, seasame, mustard and now imported palm meet this criterion. For establishing the important role of EPA and DHA ( marine sources), we can be a good control cohort. Our own large fish eating population could be the other cohort.
I recall seeing an article in the NYT/WP more than a year ago, raising questions on the claimed benefits of fish oil supplements. Don’t remember if this based on research observations. Those of you with more search capabilities and resources could find this out. Hope the so-far-held-on beneficial claims on fish w-3 will continue to hold, like the positive views on Monounsaturated fatty acids. Both are long held views and I hope the views are on more sure footing now. I am saying this in the context of two other views having been flipped in recent years, apparently backed by more research. First, the once regarded as villanous saturated fats now being held as benign to beneficial ( e.g. coconut oil, ghee, palm oil). Second, the w-6 (linoleic acid) rich oils like sunflower and safflower, once the darling of the nutrition health experts, are now cast in a shadow, their inflammatory potential. That brings them into the ambit of covid. Theoretically the connection may sound relevant, but large cohort studies are needed to establish it one way or the other. So would be the role of w-3 oils, about their inflammation controlling benefits. Let us remember that large fish eating countries like Japan, Italy, Spain, Canada ( don’t know about Iceland) did not escape the inflammatory ravages of covid ( second phase of the disease). I believe, when fish is eaten, the w-3 is present as more effective lipo proteins etc, as compared to the free oils in capsule supplements. One point. Why did not the Pfizer/Moderna chemists consider using w-3 acids in the construction of their nano lipid structures ? That would possibly have neutralised the inflammatory potential of N-methyl pseudo uridine used in their m-RNA build up. Best, use of pseudo uridine (Nobel winning) and w-3 fatty acids - both inflammation safe.
Thank you doctor for the recommendation. Its essential for people who are aging and gradually losing mental acuity. I would request you to do a show on the implication of rapidly growing variants. As far as I saw, many of the new ones popping have N-glycosylated alterations in it.
Dr McMillan - I've been trying to upgrade to paid subscription for about 2-3 months without success and have tried contacting you every possible way without any reply. It's not my card because I subscribed to both the Introductory and Advanced courses without any problem (although it took a while), so it seems the problem is at your end somewhere. I've also tried different browsers and both Windows and Linux without success. Any ideas? I'd really like to upgrade!
Interesting. Anyone have any thoughts on taking it with thrombocytopenia? Any drugs other than warfarin and blood thinners generally which make it a no-go?
Dr. McMillan, if I'm not mistaken, people with von Willebrand disease (vWD), including those with factors 2 and 5 deficiencies, also need to be cautious with supplements like Omega-3. Omega-3 fatty acids can have blood-thinning effects, which might increase bleeding risk, particularly in individuals with clotting disorders such as von Willebrand disease.
Very good point to highlight as they have a natural blood thinning effect.
What got my attention with these products is the fact that it is measurable.
Everyone still needs them, but may be more cautious in some people.
Yes, caution is crucial.
I'm particularly concerned about those who may be unaware.
Several friends, aged 40 to 70, were never tested for VWD until I brought it up. Recently, tests revealed that 9 out of 11 had at least one variant of vWF.
I wonder if some of the blood thinners or others such as statins and arthritis drugs that older people are commonly prescribed might be causing this VWD. Also how does it differ from haemophilia?
I have VWD and have been researching it for years as new papers become available.
Von Willebrand Disease (VWD) is a genetic bleeding disorder caused by a deficiency or dysfunction of von Willebrand factor (VWF)
VWD is caused by a deficiency or dysfunction of von Willebrand factor. Hemophilia, on the other hand, is usually caused by a deficiency of clotting factor VIII (in Hemophilia A) or factor IX (in Hemophilia B).
There’s no direct evidence that statins cause VWD, but they can have some effects on platelets and the clotting system,
Nonsteroidal on the other hand, anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen can inhibit platelet function, which may exacerbate bleeding in people with VWD. NSAIDs can cause gastrointestinal bleeding as well, adding to the bleeding risks in these patients.
Here are some references to the information provided:
Von Willebrand Disease (VWD) Overview:
National Hemophilia Foundation. (n.d.). What is von Willebrand Disease?
Differences Between VWD and Hemophilia:
Mayo Clinic. (2023). Von Willebrand disease.
National Heart, Lung, and Blood Institute (NHLBI). (2022). Hemophilia.
Effect of Blood Thinners on Bleeding Disorders:
American Heart Association. (2015). What You Should Know About Blood Thinners.
U.S. National Library of Medicine. (2023). Anticoagulants.
Statins and Bleeding Risks:
British Journal of Clinical Pharmacology. (2017). Statins and risk of hemorrhagic stroke: Systematic review and meta-analysis.
MedlinePlus. (2023). Statins.
NSAIDs and Bleeding Risks:
Cleveland Clinic. (2021). The Dangers of Mixing Blood Thinners and NSAIDs.
American College of Rheumatology. (2023). Nonsteroidal Anti-Inflammatory Drugs (NSAIDs).
Explanation:
Dietary and Supplement Considerations for People with von Willebrand Disease (vWD) and Omega-3
https://swaresearch.blogspot.com/2024/08/dietary-and-supplement-considerations.html
Good information and advice 👍🏻👍🏻 it is clear such supplements should not be taken without one’s doctor’s recommendation and the doctor himself should be aware of this scenario.
My first job, here in India, 45 years ago, was in vegetable oil R&D, mainly edible types, but industrial uses also. Though I had ample exposure to their industrial applications in my subsequent jobs, I have maintained very close reading touch with the edible oils, till this day, well into my long retirement. One of my top favourite subjects. For vegetarians, a large population in India, w-3 (ALA) is out of reach. In the plant kingdom, only Flaxseed, Perilla, Camelina, & Hempseed contain more than 25% of ALA, these are not everyday oils. Mustard ( a favourite in north India and Soybean ( used here in some blended oils) contain single digit levels of w-3. It is also said that plant based w-3 need to be converted into the marine type by the body for effectiveness and this process is not very efficient. So much so, we vegetarians have evolved to make do without w-3, for all practical purposes. So, for us, the major criterion is now only maximising oleic content. Fortunately, our traditional oils like ground nut, seasame, mustard and now imported palm meet this criterion. For establishing the important role of EPA and DHA ( marine sources), we can be a good control cohort. Our own large fish eating population could be the other cohort.
Very important information thats not available to many people
I recall seeing an article in the NYT/WP more than a year ago, raising questions on the claimed benefits of fish oil supplements. Don’t remember if this based on research observations. Those of you with more search capabilities and resources could find this out. Hope the so-far-held-on beneficial claims on fish w-3 will continue to hold, like the positive views on Monounsaturated fatty acids. Both are long held views and I hope the views are on more sure footing now. I am saying this in the context of two other views having been flipped in recent years, apparently backed by more research. First, the once regarded as villanous saturated fats now being held as benign to beneficial ( e.g. coconut oil, ghee, palm oil). Second, the w-6 (linoleic acid) rich oils like sunflower and safflower, once the darling of the nutrition health experts, are now cast in a shadow, their inflammatory potential. That brings them into the ambit of covid. Theoretically the connection may sound relevant, but large cohort studies are needed to establish it one way or the other. So would be the role of w-3 oils, about their inflammation controlling benefits. Let us remember that large fish eating countries like Japan, Italy, Spain, Canada ( don’t know about Iceland) did not escape the inflammatory ravages of covid ( second phase of the disease). I believe, when fish is eaten, the w-3 is present as more effective lipo proteins etc, as compared to the free oils in capsule supplements. One point. Why did not the Pfizer/Moderna chemists consider using w-3 acids in the construction of their nano lipid structures ? That would possibly have neutralised the inflammatory potential of N-methyl pseudo uridine used in their m-RNA build up. Best, use of pseudo uridine (Nobel winning) and w-3 fatty acids - both inflammation safe.
Thank you doctor for the recommendation. Its essential for people who are aging and gradually losing mental acuity. I would request you to do a show on the implication of rapidly growing variants. As far as I saw, many of the new ones popping have N-glycosylated alterations in it.
Dr McMillan - I've been trying to upgrade to paid subscription for about 2-3 months without success and have tried contacting you every possible way without any reply. It's not my card because I subscribed to both the Introductory and Advanced courses without any problem (although it took a while), so it seems the problem is at your end somewhere. I've also tried different browsers and both Windows and Linux without success. Any ideas? I'd really like to upgrade!
Did you try clearing your cookies for substack.com domain and restarting the browser?
Interesting. Anyone have any thoughts on taking it with thrombocytopenia? Any drugs other than warfarin and blood thinners generally which make it a no-go?