I do not have any concerns about using the veterinary "paste", and yes it requires some energy and effort, more than I could muster, to acquire the pills and then have concerns about if they are real. I do not see much risk, if any, that "paste" bought through established retail chains would be counterfeited.
I do not have any concerns about using the veterinary "paste", and yes it requires some energy and effort, more than I could muster, to acquire the pills and then have concerns about if they are real. I do not see much risk, if any, that "paste" bought through established retail chains would be counterfeited.
I trust the Durvet brand paste version manufactured in Canada and distributed from Blue Springs Missouri which is given to valuable horses on a regular basis, horses which are valued by their owners more than people's lives are valued by the powers that be. The Ivermectin is already dispersed in corn oil which aids in absorption, then gelled with food grade silica. Yes the artificial apple flavor is bad tasting. I have heard from at least one credible source the ivermectin manufactured for animals is as high a quality as that for humans, the formulation into pills or ointment for humans vs jells, injectable liquid or for dilution to make a wash for animals is the difference.
I expect there is no counterfeiting of horse paste sold through regular distribution channels. I expect both some counterfeiting and sloppy manufacturing of ivermectin pills so long as the price remains "jacked up".
now $9.99 to $10.49 per tube, prices vary a bit over time and location. (it was 2 tubes for $5.00, ~ 2.5 cents per mg of ivermectin back in August 2020 when I sent out my email "buy recommendation") This $9.99 to $10.49 cost per tube of paste makes the per milligram cost of ivermectin about 10 cents. In stock now at some area stores, website will tell you availability if you "ask" or phone store. I just asked and it is still "over the counter" status (a vet prescription is not required at this time).
Very easy to accurately measure dose in milligrams of ivermectin or by your weight, as each notch on the "syringe" tube plunger extrudes a bit over 4.5 milligrams. and each "notch" is calibrated to extrude the amount of paste to provide a (old) standard 0.2 mg per kg of body weight dose for 50 pounds worth of "mammal". There is a stop guide on the plunger, it unlocks with a 1/4 turn counter clockwise, then move the stop back from the tube base the number of desired notches then turn the stop clockwise the ~1/4 turn to lock it and push the plunger. a knife can be used to cut off the dose. (a single edge razor blade works well if you wanted to further divide to 1+ or 2+ milligram bits of paste. for instance 3 notches for 150 pounds of person or 6 notches for the stronger 0.4 mg/kg "double" dose for 150 pounds.
Most all doctors now double or triple the old "standard dose" . You may see guidelines based on number of milligrams for your weight and disease stage at the FLCCC here https://covid19criticalcare.com/ search treatment protocols then read I-CARE
Early Covid Treatment "Ivermectin: 0.4 to 0.6 mg/kg – one dose daily for at least 5 days or until symptoms resolve." check for current guidelines.
A 100 pound person taking the starting 0.4 mg/kg one dose daily would use 4 "notches" per day. there are 25 notches per tube so 6 doses and a bit. 1 tube is the minimum to provide the minimum dose for a 100 pound person minimum course of treatment
I have taken the "old" standard ivermectin "paste" dose (it is in corn oil then "jelled" with food grade silica to prevent separation) in a tablespoon of olive oil and dissolve it into the olive oil with a bit of stirring with a butter knife or small spoon. Then I take it with food that also has a good bit of fat for higher absorption as seen here https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050742s022lbl.pdfmeal. "Administration of 30 mg ivermectin following a high-fat (48.6 g of fat) meal resulted in an approximate 2.5 fold increase in bioavailability relative to administration of 30 mg ivermectin in the fasted state."
an "old" standard weight based dose taken in this manner MAY well (probably does) have the effect of a higher dose via pill taken without the fat needed to increase absorption . It has been shown that treatment outcome is better with higher doses. I would now both use the higher recommended dose guidelines and the "fat" added with the understanding I was absorbing more with the fat additions. Or in the extreme, a 100 mg dose as Dr. Jackie Stone in Zimbabwe took when, from covid infection from the South African strain, her blood oxygen was declining, her blood "clumping" leading to micro clotting to "clotting out". A life saving 100mg dose which caused temporary visual "wave pool" side effects to which Dr Jackie stone replied "Excellent, I've had enough". Dr. Jackie Stone account is here https://medicalupdateonline.com/2021/04/the-patient-experience-of-ivermectin/
The takeaway I have gleaned is, if infected, I want to take a high enough dose, especially initially, and absorb the dose to have a rapid effect
I used online ordering with curbside pickup. The key is to have some at home and take enough and take it early.
Some good "horse story" may be useful to have at the ready, curb side delivery? may reduce questioning if this is or becomes the norm when purchasing "paste"
I wrote this reply to Suzy's Substack after reading this in one of her comments "I did get a ridiculous 5 page letter from my insurance company with a HORSE picture and how ineffective and dangerous this dewormer is! Seriously I couldn't believe it!"
my reply "HORSE picture" I started buying "the dewormer" at Tractor Supply in August 2020 before it became so "controversial".
When I made later purchases for friends I brought a Christmas card "HORSE picture" from my sister which was a winter scene picture of her horse and the rest of her family. I had a "Rockford Files" type horse story ready to go if questioned, which never happened. Though I have heard a person purchasing "paste" today may be "subject to questioning".
Yours Truely
James
edit: I checked the ivermectin "fat" link - surprise! surprise! the link now goes to the FDA and the FDA page says "Page Not Found". Yet for now that study result is still referenced here https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050742s022lbl.pdf for the record the relative referenced result for the "page not found" study is copied below
"CLINICAL PHARMACOLOGY
Pharmacokinetics
Following oral administration of ivermectin, plasma concentrations are approximately proportional to the dose. In two studies, after single 12-mg doses of STROMECTOL in fasting healthy volunteers (representing a mean dose of 165 mcg/kg), the mean peak plasma concentrations of the major component (H 2B 1a) were 46.6 (±21.9) (range: 16.4-101.1) and 30.6 (±15.6) (range: 13.9-68.4) ng/mL, respectively, at approximately 4 hours after dosing. Ivermectin is metabolized in the liver, and ivermectin and/or its metabolites are excreted almost exclusively in the feces over an estimated 12 days, with less than 1% of the administered dose excreted in the urine. The plasma half-life of ivermectin in man is approximately 18 hours following oral administration. The safety and pharmacokinetic properties of ivermectin were further assessed in a multiple-dose clinical pharmacokinetic study involving healthy volunteers. Subjects received oral doses of 30 to 120 mg (333 to 2000 mcg/kg) ivermectin in a fasted state or 30 mg (333 to 600 mcg/kg) ivermectin following a standard high-fat (48.6 g of fat) meal. Administration of 30 mg ivermectin following a high-fat meal resulted in an approximate 2.5
fold increase in bioavailability relative to administration of 30 mg ivermectin in the fasted state."
2 sentences to notice here
1) "Subjects received oral doses of 30 to 120 mg (333 to 2000 mcg/kg) ivermectin in a fasted state"
note the 120 mg dose given to test subjects
2) "or 30 mg (333 to 600 mcg/kg) ivermectin following a standard high-fat (48.6 g of fat) meal. Administration of 30 mg ivermectin following a high-fat meal resulted in an approximate 2.5
fold increase in bioavailability relative to administration of 30 mg ivermectin in the fasted state."
I checked the ingredients at their website, looked over the material data safety disclosure etc. I found no reference to titanium dioxide in the ingredients of the Durvet brand. It is a transparent light amber colored jell so no indication of titanium dioxide by physical inspection Some brands are a opaque whitish color (as referenced in reviews in their consumer comments section) which may well be a titanium dioxide coloring additive.
Yes I agree no consumption of titanium dioxide is the best way. In a time long long ago, in a "space" far far away I remember reading "titanium dioxide" as an ingredient in powdered donuts.
If I was sick with covid etc. I expect the benefit from taking ivermectin containing titanium dioxide would override harm from titanium dioxide. It may also be in some of the pills?
I do not have any concerns about using the veterinary "paste", and yes it requires some energy and effort, more than I could muster, to acquire the pills and then have concerns about if they are real. I do not see much risk, if any, that "paste" bought through established retail chains would be counterfeited.
I trust the Durvet brand paste version manufactured in Canada and distributed from Blue Springs Missouri which is given to valuable horses on a regular basis, horses which are valued by their owners more than people's lives are valued by the powers that be. The Ivermectin is already dispersed in corn oil which aids in absorption, then gelled with food grade silica. Yes the artificial apple flavor is bad tasting. I have heard from at least one credible source the ivermectin manufactured for animals is as high a quality as that for humans, the formulation into pills or ointment for humans vs jells, injectable liquid or for dilution to make a wash for animals is the difference.
I expect there is no counterfeiting of horse paste sold through regular distribution channels. I expect both some counterfeiting and sloppy manufacturing of ivermectin pills so long as the price remains "jacked up".
I bought tubes of Durvet Apple Flavor Ivermectin 1.87% Horse Wormer Paste in the US at Tractor Supply. I just looked (August 2023) at the "paste" page here https://www.tractorsupply.com/tsc/search/ivermectin%20horse%20paste?
now $9.99 to $10.49 per tube, prices vary a bit over time and location. (it was 2 tubes for $5.00, ~ 2.5 cents per mg of ivermectin back in August 2020 when I sent out my email "buy recommendation") This $9.99 to $10.49 cost per tube of paste makes the per milligram cost of ivermectin about 10 cents. In stock now at some area stores, website will tell you availability if you "ask" or phone store. I just asked and it is still "over the counter" status (a vet prescription is not required at this time).
Very easy to accurately measure dose in milligrams of ivermectin or by your weight, as each notch on the "syringe" tube plunger extrudes a bit over 4.5 milligrams. and each "notch" is calibrated to extrude the amount of paste to provide a (old) standard 0.2 mg per kg of body weight dose for 50 pounds worth of "mammal". There is a stop guide on the plunger, it unlocks with a 1/4 turn counter clockwise, then move the stop back from the tube base the number of desired notches then turn the stop clockwise the ~1/4 turn to lock it and push the plunger. a knife can be used to cut off the dose. (a single edge razor blade works well if you wanted to further divide to 1+ or 2+ milligram bits of paste. for instance 3 notches for 150 pounds of person or 6 notches for the stronger 0.4 mg/kg "double" dose for 150 pounds.
Most all doctors now double or triple the old "standard dose" . You may see guidelines based on number of milligrams for your weight and disease stage at the FLCCC here https://covid19criticalcare.com/ search treatment protocols then read I-CARE
Early Covid Treatment "Ivermectin: 0.4 to 0.6 mg/kg – one dose daily for at least 5 days or until symptoms resolve." check for current guidelines.
A 100 pound person taking the starting 0.4 mg/kg one dose daily would use 4 "notches" per day. there are 25 notches per tube so 6 doses and a bit. 1 tube is the minimum to provide the minimum dose for a 100 pound person minimum course of treatment
I have taken the "old" standard ivermectin "paste" dose (it is in corn oil then "jelled" with food grade silica to prevent separation) in a tablespoon of olive oil and dissolve it into the olive oil with a bit of stirring with a butter knife or small spoon. Then I take it with food that also has a good bit of fat for higher absorption as seen here https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050742s022lbl.pdfmeal. "Administration of 30 mg ivermectin following a high-fat (48.6 g of fat) meal resulted in an approximate 2.5 fold increase in bioavailability relative to administration of 30 mg ivermectin in the fasted state."
an "old" standard weight based dose taken in this manner MAY well (probably does) have the effect of a higher dose via pill taken without the fat needed to increase absorption . It has been shown that treatment outcome is better with higher doses. I would now both use the higher recommended dose guidelines and the "fat" added with the understanding I was absorbing more with the fat additions. Or in the extreme, a 100 mg dose as Dr. Jackie Stone in Zimbabwe took when, from covid infection from the South African strain, her blood oxygen was declining, her blood "clumping" leading to micro clotting to "clotting out". A life saving 100mg dose which caused temporary visual "wave pool" side effects to which Dr Jackie stone replied "Excellent, I've had enough". Dr. Jackie Stone account is here https://medicalupdateonline.com/2021/04/the-patient-experience-of-ivermectin/
The takeaway I have gleaned is, if infected, I want to take a high enough dose, especially initially, and absorb the dose to have a rapid effect
I used online ordering with curbside pickup. The key is to have some at home and take enough and take it early.
Some good "horse story" may be useful to have at the ready, curb side delivery? may reduce questioning if this is or becomes the norm when purchasing "paste"
I wrote this reply to Suzy's Substack after reading this in one of her comments "I did get a ridiculous 5 page letter from my insurance company with a HORSE picture and how ineffective and dangerous this dewormer is! Seriously I couldn't believe it!"
my reply "HORSE picture" I started buying "the dewormer" at Tractor Supply in August 2020 before it became so "controversial".
When I made later purchases for friends I brought a Christmas card "HORSE picture" from my sister which was a winter scene picture of her horse and the rest of her family. I had a "Rockford Files" type horse story ready to go if questioned, which never happened. Though I have heard a person purchasing "paste" today may be "subject to questioning".
Yours Truely
James
edit: I checked the ivermectin "fat" link - surprise! surprise! the link now goes to the FDA and the FDA page says "Page Not Found". Yet for now that study result is still referenced here https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050742s022lbl.pdf for the record the relative referenced result for the "page not found" study is copied below
"CLINICAL PHARMACOLOGY
Pharmacokinetics
Following oral administration of ivermectin, plasma concentrations are approximately proportional to the dose. In two studies, after single 12-mg doses of STROMECTOL in fasting healthy volunteers (representing a mean dose of 165 mcg/kg), the mean peak plasma concentrations of the major component (H 2B 1a) were 46.6 (±21.9) (range: 16.4-101.1) and 30.6 (±15.6) (range: 13.9-68.4) ng/mL, respectively, at approximately 4 hours after dosing. Ivermectin is metabolized in the liver, and ivermectin and/or its metabolites are excreted almost exclusively in the feces over an estimated 12 days, with less than 1% of the administered dose excreted in the urine. The plasma half-life of ivermectin in man is approximately 18 hours following oral administration. The safety and pharmacokinetic properties of ivermectin were further assessed in a multiple-dose clinical pharmacokinetic study involving healthy volunteers. Subjects received oral doses of 30 to 120 mg (333 to 2000 mcg/kg) ivermectin in a fasted state or 30 mg (333 to 600 mcg/kg) ivermectin following a standard high-fat (48.6 g of fat) meal. Administration of 30 mg ivermectin following a high-fat meal resulted in an approximate 2.5
fold increase in bioavailability relative to administration of 30 mg ivermectin in the fasted state."
2 sentences to notice here
1) "Subjects received oral doses of 30 to 120 mg (333 to 2000 mcg/kg) ivermectin in a fasted state"
note the 120 mg dose given to test subjects
2) "or 30 mg (333 to 600 mcg/kg) ivermectin following a standard high-fat (48.6 g of fat) meal. Administration of 30 mg ivermectin following a high-fat meal resulted in an approximate 2.5
fold increase in bioavailability relative to administration of 30 mg ivermectin in the fasted state."
Hi James, that’s a very considered and comprehensive reply and I am grateful for the time, thought and experience you put into writing it. Regards
I checked the ingredients at their website, looked over the material data safety disclosure etc. I found no reference to titanium dioxide in the ingredients of the Durvet brand. It is a transparent light amber colored jell so no indication of titanium dioxide by physical inspection Some brands are a opaque whitish color (as referenced in reviews in their consumer comments section) which may well be a titanium dioxide coloring additive.
Yes I agree no consumption of titanium dioxide is the best way. In a time long long ago, in a "space" far far away I remember reading "titanium dioxide" as an ingredient in powdered donuts.
If I was sick with covid etc. I expect the benefit from taking ivermectin containing titanium dioxide would override harm from titanium dioxide. It may also be in some of the pills?