Discussion with Jennifer Smith PhD (Virology, Epidemiology) and Janci Lindsay PhD (Biochemistry, Molecular Biology) about their views on Covid, vaccines and the trend of the pandemic.
Whereas most patients maintained humoral immunity throughout the observation period, we observed reduced cellular immune reactivity as measured by the ancestral-strain-stimulated ELISpot assay in a subset of patients. Half of the individuals (50%; 14/28) maintained cellular immunity three months after the fifth dose, despite acquiring humoral immunity.
Tani Y, Takita M, Wakui M, Saito H, Nishiuchi T, Zhao T, Yamamoto C, Kawamura T, Sugiyama A, Nakayama A, Kaneko Y, Kodama T, Shinaha R, Tsubokura M. Five doses of the mRNA vaccination potentially suppress ancestral-strain stimulated SARS-CoV2-specific cellular immunity: a cohort study from the Fukushima vaccination community survey, Japan. Front Immunol. 2023 Aug 16;14:1240425. doi: 10.3389/fimmu.2023.1240425. PMID: 37662950; PMCID: PMC10469480.
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Where is the COVID-19 pandemic now?