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I appreciate your hypothesis of these agents contributing to an altered extracellular and intracellular microenvironment. As a result , providing the negating effect on the virus and its replication. Our focus was more on the host rather than the virus at that time. Based on the fact and rationale that we had very little time and resources to study the virus and then develop agents to counter it.

My opinion about antiparasitic agents being effective during the pandemic is based on the fact that they have been successfully repurposed as antiinflammatory and immunomodulators in chronic inflammatory and autoimmune diseases. Early addition of these agents during the initial upper respiratory tract symptoms justified their prophylactic role against the second phase. With the appropriate addition of the corticosteroids, helped contained the progressing life threatening lower respiratory tract inflammation ( refered to hypersensitive pneumonitis) and restoration of oxygen saturation.

While the use of antihistamines and mast cell stabilisers helped in the management of the upper respiratory tract symptoms. In addition we corrected the essential and micronutrient deficiency alongside. We also found significant benefits and synergestic effects when we used our compounded herbo mineral preparation with proven antihypersensitive, antiinflammatory and immunomodulating properties. As part of our Integrative medicine and functional nutrition protocols. We continue to use this approach in those presenting with adverse events of the vaccine (which are essentially the unwanted systemic effects of the antigenic spike protein)

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Unlike researchers, for hands on doctors like you, I am not sure if exclusive focus either on the host or the virus is possible in your daily practice. They are one and the same, even in the second phase where the virus takes the backseat in controlling the disease. The repurposed anti virals can work with two clear focuses. Example, an anti histamine will mitigate the histamine release based symptoms of the host. Its repurposed anti viral property will directly work on the virus stopping the load build up. All these considerations are now history, as with Omicrons the second phase is absent. But its milder viral phase ( only phase) cannot be ignored from early URT treatments, unlike similar looking common cold. How have handled it in the last 2 years ? I cannot still figure out why the Omicrons have continued to roil the USA with deaths, about 4000 plus per month even now. Even with the continuing shunning of early treatment protocols, even with the claims it is all people with predispositions ( which I do not accept), this phenomenon of mortality is unprecedented and unacceptable. Any thoughts ? Are you able to exclude Omicron based mortality in your cases. You know very well how Omicron is totally out of currency in many parts of the world, including India, for two years now.

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The cases reported across india are highly insignificant to cause any alarm. Moreover strain specific testing is not at all a common practice. The new normal of excess mortality and life disabling/ threatening morbidities being reported across the highly vaccinated populations deserves critical investigation. From the beginning i was never convinced with mRNA approach to vaccination

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