The description of the problem is rather correct. But the scope of the problem is rather not. This will not be a tsunami, I hope. The hope is based on the following considerations:
- SARS-CoV-2 shall become non-antigenic to vaccinal S-specific memory B and T cell via glycosylation and not be means of protein changes. Epitopes shall remain the same, but the epitopes shall not be reached. There will be limited vaccinal immune response against the new strains of the virus and this shall trigger/require training of innate immunity, that is the only instrument out of endless pandemic.
- vaccinal S-specific memory B cells are long lived plasma blasts not long-lived bone marrow plasma cells. Therefore, vaccinal priming is not irreversible. Post 12-months period after final boost there should be no vaccinal B cells in a majority of vaccinated cohort, I hope. Therfore, ADEI is not life-long risk.
- There should be limited number of non-infected vaccinees. Therefore, even vaccinees have primed immune response (B and T cell) against M, N, E and some nonstructural and accessory proteins, sufficient to avoid autoimmune reactions.
- Phagocytoses, NK cell cytotoxic activity, even vaccinal Abs cytolytic activity all can be sufficient to recognise, neutralize and clear the antigen before it causes adverse effects.
Do not focus so much on threats and weaknesses. Look to strengths and opportunities for objective SWOT analysis of the pandemic. Do not underestimate the innate immunity like vaccinees do. The nature tends to preserve a balance between the pathogen and the host. We shall see, if the host lets the nature to solve the problems its created.
Thank for a very insightful commentary, I was very depressed at the hypothesis that vaccinal priming was irreversible for vaccinees but your expectations that this should be limited to a year gives me hope
Your first consideration suggests that variant-specific vaccines should not be taken, because they could create high levels of antibody (one benchmark of effectiveness FDA is accepting) which would again prevent the innate immunity from starting to train.
My suggestion is that everyone should be fully informed about the benefits and risks, short-term and long-term consequences of the drugs they take. And no drug should be taken without proper information about those factors. Those factors can be assessed individually.
Vaccines should be included in the toolbox of strategies of prophylaxes and treatment of SARS-CoV-2 and it’s caused Covid-19. But there are multiple safe, effective and available strategies how to ensure the benefits Covid-19 vaccines provide (namely immune tolerance against the pathogen, reduction of viral loads and faster clearance of the viral particles) can be substituted with more suitable drugs for the needs of individual patient.
However since there has never been a successful neutralizing vaccine against a coronavirus, we have to be suspicious about the claims they have already made about the Covid-19 vaccines and demand to see all their data. Until a lab actually proves they can work, perhaps vaccines simply should not be in the toolbox for coronaviruses.
I am not a doctor. But I do have plenty of common sense and have been following all this very close for over 2 years. What you are saying could be good, but does not correlate with reality. The reality is that the mass media, along with most doctors around the world, scared people SO much, that they could not make a good decision, objective, based on informed consent and honest information on potential long term side effects. Mandates or not, people from every country, every age, every health status, were convinced, or forced into multiple vaccines, even mixing and matching, spaced out or not, with or without natural infection (which by the way keeps getting ignored and devalued). And it is still happening. Even teens and children are being injected over and over, without any supervision from doctors, even knowing that most at this point (after more that 2 years), have acquired robust natural immunity. Most of the world is busy trying to survive insane government decisions which led to economic, social and psychological crisis. They don't wake up in the morning and go straight to do research on vaccine long term effect. They get a message on their cell phones, reminding them that they have an appointment for their 3th, 4th, or 5th shot, and they just go get it and move on. Basically, until health authorities and governments put a STOP to the constant vaccination campaign, the natural infection will not be able to do what it's supposed to do, and the immune system will keep getting "spiked", with potential further damage. I sincerely hope I am wrong :(
Regarding those who got injected once or twice but are hoping to get boosters from infection rather than another injection, there should be some good studies out of Israel, but i dont have them to hand at the moment.
Significant findings. Vaccine effects, on an average, do not last 4 months. The most important cohort now are those who have had infections and were also vaccinated at least thrice. Will this group in Qatar study them ? We need to know the overlapping influence of vaccines on the natural protection from primary infection. The clear biology. All that can be said now is that the vaccines effects would have disturbed the naturally obtained protection. Hybrid immunity in this case is a myth.
Good study, I saw DrBeen go through it. I am a great example of that. No vx. Had Covid april 21, not so mild and not so severe either. Got covid again Jan 22, Omicron most likely, hardly any symptoms. No lingering issues. Husband: vxd twice, got covid, got Epstein Barr Virus reactivation
If I understand you correctly, your point is that only sterilizing vaccines should be authorized under current circumstances to stop the viral transmission and to end the pandemic. And since the current vaccines induce non-neutralizing Abs that enhances the infection, the current vaccines should not be used. But, please be precise, because sterilizing and neutralizing are different concepts, and clinical trials are not limited to studies in lab.
I would still argue that the main problem with the vaccination against C19 has not been wrong vaccines designs, defective clinical trials, etc., but the problem has been unjustified vaccines mandates. There was well established case-law in the U.S. (Jacobson v. Massachusetts, etc.) and in the EU (Vavrička case) stating that only vaccines leading to herd immunity can be mandated. And it is well known that intramuscular vaccines can’t induce the necessary immune response in the upper respiratory tract against airborne respiratory virus to stop the transmission leading to herd immunity. But being aware of this knowledge the C19 vaccines were mandated, and mandates still enjoy protection when scrutinized in a judicial process. This is crazy.
With regard to vaccine design the S-directed immune response is justified approach. This is based on studies with SARS-CoV, which suggested that during natural infection body secreted primary S-directed Abs and T cells. And secondly, SARS-CoV-2 does not have much epitopes left to target with the vaccines because it is heavily glycosylated and conceals its epitopes. But still there are smarter vaccines design alternatives against SC2, which are not so financially-wise since they would serve to end the pandemic.
With regard to C-19 vaccine clinical trials there were significant defects in the protocols for the trials since drug agencies do not pay attention to population level dynamics of the viral evolution. Simple additions to vaccines trials would be sufficient (e.g. https://doi.org/10.1371%2Fjournal.pbio.3001000). And it is not possible to modulate the real-life pandemic conditions even in the lab with the most sophisticated AI. Therefore, clinical trials of pandemic drugs are going to mislead about real-time population-wide effects.
And if you argue about updated vaccines against new SC2 viral strains, there always remains the problem with original antigenic sin that was even an issue with Wuhan strain vaccines which did not prime new response by induced cross-reactive response from previous infections with HCoV-OC43 in many vaccinees.
I agree the mandates are unjustified, both by failure of effectiveness and lack of necessity.
Mandates are also illegal because you cannot do medical experiments on people without consent. The vaccines are experimental - none of them have completed even the "accelerated" phase 3 clinical trials, and they can never be completed now because of unblinding and injecting the control group.
Most importantly, proponents of the vaccines have failed to count serious adverse events caused by the vaccines during trials and delivery, and continue to deliberately mislead the public about it. There is still no assessment of long term risks, because studies were not done and pregnant women and kids are being injected despite never completing trials. Moreover, they have suppressed research and results of possible effective treatments. We simply cannot trust products and their proponents (corporate, government, scientific, medical) under such circumstances, at least until those responsible are held to account (unlikely in the near future).
"Sterilizing" was part of the definition until someone at the CDC decided to redefine the term itself (as if by doing so he could alter reality), so yeah.
I’ve found your videos very interesting and I’m keeping an open mind - I always like to weigh up all sides.
My personal position is that my fit and healthy wife was fine until she had her second vaccine. She works for the nhs so got them quite early (both Pfizer). As well as working for the nhs she was also a freelance fitness instructor at local gyms teaching mostly body pump and spin, quite often back to back. After the second vaccine she seemed to have overreactions to insect bites, developed shingles, was out of breath to the extent she couldn’t walk a small walk without getting out of breath. She’s currently under the long covid clinic and recently been diagnosed with rheumatoid arthritis. Maybe just coincidental but there do appear to be others with similar issues.
Keep doing your videos - I am disgusted with the way the majority of governments worldwide have treated the public like idiots and not allowed people to choose for themselves. My wife stood to lose her job (at least the threat) if she didn’t get vaccinated. She felt railroaded into getting it and can’t help but think if her health deterioration would have happened if she refused, as do I and the rest of the family.
Very unfortunate. Many families have such stories post vaccination. My studied hope is that these conditions will go away in time, especially since your wife was fit and active before. Let her get the standard treatments for whatever indications that crop up. Her Rheumatoid arthritic medicines might might clean up her residual viral load and help recovery in her other conditions. Most anti inflammatories are also anti virals and they could clear even the vaccine remnants, which are the pathogenic spike proteins. As an organic chemist, I am confident of the chemistry behind this hope. If you are in a position to visit South Africa, Dr. Chetty is your best hope. I would be following this sub stack for progress in her condition. God bless you both 🙏
Thank you Dr McMillan. I didn't really expect anything other than this prognosis. WE warned "them." "they" ignored and silenced US. Now we must continue to expose "them" and at the same time help the ONES' "they've" hurt. IMO "they" have been planning this for a very, very, very, long time. WE'RE doing GREAT! given that WE'VE only had 2+ years to figure this out. EVERYONE . . . ENDEAVEOR TO PERSEVER please.
The health of the host is paramount for efficient functioning of the immune system. Unhealthy people who ignore health, diet and lifestyle advice, and with high already inflammation markers are doubtless going to suffer more adverse effects from both the continued boosters and the repeated infections. Based on U.K. ONS stats we have already seen a 16% increase in all cause mortality in the past year, unrelated to Covid. These stats appear to be mirrored in other parts of the world where vaccination levels are high. This is going to be a case of survival of the fittest… maybe that’s not a bad thing either when you consider the pressure humans are putting on the planet!
It need not be more deaths if not for the vaccines.
COVID infection even among the people with comorbidities when treated early does not even require hospitalisation. The community across the globe has joined groups on Telegram and helped one another in getting remedies for early intervention and even for prophylaxis through simple vitamins such as Dr Zelenko and the FLCCC (flccc.net) had advised. We didn't wait for post 8th day for Dr Chetty's protocol because many people across the globe do not have access to doctors who dared to treat covid. Even many telehealth doctors in USA were not willing to prescribe medication of proper dosage and the group saw a few who ended up with severe covid and huge anxiety in the hospital, fighting hard to not be administered with Remdesivir. There were a few whose loved ones ended up in hospital and died as they were not aware of the early treatment protocols and the hospital refused them the therapeutics even when family printed out FLCCC's protocol for severe covid.
Many of us were able to not be at the mercy of doctors or hospitals. We took our vitamins or sunshine for those in non-temperate countries and stayed covid-free for the past 2 years.
Early treatment from day 1 of symptoms or even upon knowledge of exposure to covid works and we don't have autoimmune reactions or long covid.
This has precisely been my stand, early treatments ( from day 1, some URT symptoms) and common URT medicines. My earlier messaging was only through hundreds of newspaper letters and personal mails to known researchers in covid, including Dr. McMillan. Even though I have heard many of his videos before, only recently I could get into reading of his podcasts and the access to these comments columns. I am aware early treatments in covid was not an option with the doctors in the USA. A few days of safe OTC anti histamines like fexofenadine or Levocetrizine would have saved lot of hardships, including avoiding auto immune phases.
The West has not realised that covid like situations are best handled by clinicians and physicians at their patient level, sharing their work on appropriate social media. By continuing to let virologists, epidemiologists and administrators to control public response, they are sure to be hit by the tsunami next time. The entire world followed them in 2020 and early 2021 including the wait for vaccines. But many lesser countries saw the futility of this approach during the delta run in 2021, let the doctors and clinicians take over with early treatments and classical URT medicines like Azithromycin, Montelukast, Levocetrizine etc and have completely driven this virus into a hole. Next time, they won’t be stumped by auto immune presentations or whatever. They will hit the disease directly.
"There are options available, but requires current scientific leadership to step back and allow others to lead. Not sure this will happen, and the outcomes could be disastrous."
I am 100% sure it will not happen, and 90% sure the outcome will be disastrous - it's just a matter of scale and timing.
The emergence of SARS-CoV-2 variants with enhanced transmissibility, pathogenesis, and resistance to vaccines presents urgent challenges for curbing the COVID-19 pandemic. While Spike mutations that enhance virus infectivity or neutralizing antibody evasion may drive the emergence of these novel variants, studies documenting a critical role for interferon responses in the early control of SARS-CoV-2 infection,
Viruses are obligate parasites that rely on host cell synthesis machinery to replicate. A major advancement in the field of chronobiology is the realization that host susceptibility to an infectious agent is not only dependent on the viral inoculum size, transmission route and length of exposure, but on the time of day when the pathogen is encountered. Multiple studies have demonstrated that many viruses are directly or indirectly influenced by the circadian-regulated pathway's
Viruses are obligate parasites that rely on host cell synthesis machinery to replicate. A major advancement in the field of chronobiology is the realization that host susceptibility to an infectious agent is not only dependent on the viral inoculum size, transmission route and length of exposure, but on the time of day when the pathogen is encountered. Multiple studies have demonstrated that many viruses are directly or indirectly influenced by the circadian-regulated pathway's
Some evidence indicates that DPP-4 inhibitors might inhibit the entrance of coronavirus into the airways, which suggests an additional therapeutic approach to COVID-19 treatment
Coagulation problems have also been seen in post-COVID-19 survivors and in PPCS patients, to whom anticoagulants are routinely prescribed. Despite the variety and significance of the symptoms reported by numerous COVID-19 survivors with or without PPCS, valuable biomolecular markers to monitor this condition are still lacking.
The description of the problem is rather correct. But the scope of the problem is rather not. This will not be a tsunami, I hope. The hope is based on the following considerations:
- SARS-CoV-2 shall become non-antigenic to vaccinal S-specific memory B and T cell via glycosylation and not be means of protein changes. Epitopes shall remain the same, but the epitopes shall not be reached. There will be limited vaccinal immune response against the new strains of the virus and this shall trigger/require training of innate immunity, that is the only instrument out of endless pandemic.
- vaccinal S-specific memory B cells are long lived plasma blasts not long-lived bone marrow plasma cells. Therefore, vaccinal priming is not irreversible. Post 12-months period after final boost there should be no vaccinal B cells in a majority of vaccinated cohort, I hope. Therfore, ADEI is not life-long risk.
- There should be limited number of non-infected vaccinees. Therefore, even vaccinees have primed immune response (B and T cell) against M, N, E and some nonstructural and accessory proteins, sufficient to avoid autoimmune reactions.
- Phagocytoses, NK cell cytotoxic activity, even vaccinal Abs cytolytic activity all can be sufficient to recognise, neutralize and clear the antigen before it causes adverse effects.
Do not focus so much on threats and weaknesses. Look to strengths and opportunities for objective SWOT analysis of the pandemic. Do not underestimate the innate immunity like vaccinees do. The nature tends to preserve a balance between the pathogen and the host. We shall see, if the host lets the nature to solve the problems its created.
Thank for a very insightful commentary, I was very depressed at the hypothesis that vaccinal priming was irreversible for vaccinees but your expectations that this should be limited to a year gives me hope
Your first consideration suggests that variant-specific vaccines should not be taken, because they could create high levels of antibody (one benchmark of effectiveness FDA is accepting) which would again prevent the innate immunity from starting to train.
My suggestion is that everyone should be fully informed about the benefits and risks, short-term and long-term consequences of the drugs they take. And no drug should be taken without proper information about those factors. Those factors can be assessed individually.
Vaccines should be included in the toolbox of strategies of prophylaxes and treatment of SARS-CoV-2 and it’s caused Covid-19. But there are multiple safe, effective and available strategies how to ensure the benefits Covid-19 vaccines provide (namely immune tolerance against the pathogen, reduction of viral loads and faster clearance of the viral particles) can be substituted with more suitable drugs for the needs of individual patient.
Agreed, in general.
However since there has never been a successful neutralizing vaccine against a coronavirus, we have to be suspicious about the claims they have already made about the Covid-19 vaccines and demand to see all their data. Until a lab actually proves they can work, perhaps vaccines simply should not be in the toolbox for coronaviruses.
I am not a doctor. But I do have plenty of common sense and have been following all this very close for over 2 years. What you are saying could be good, but does not correlate with reality. The reality is that the mass media, along with most doctors around the world, scared people SO much, that they could not make a good decision, objective, based on informed consent and honest information on potential long term side effects. Mandates or not, people from every country, every age, every health status, were convinced, or forced into multiple vaccines, even mixing and matching, spaced out or not, with or without natural infection (which by the way keeps getting ignored and devalued). And it is still happening. Even teens and children are being injected over and over, without any supervision from doctors, even knowing that most at this point (after more that 2 years), have acquired robust natural immunity. Most of the world is busy trying to survive insane government decisions which led to economic, social and psychological crisis. They don't wake up in the morning and go straight to do research on vaccine long term effect. They get a message on their cell phones, reminding them that they have an appointment for their 3th, 4th, or 5th shot, and they just go get it and move on. Basically, until health authorities and governments put a STOP to the constant vaccination campaign, the natural infection will not be able to do what it's supposed to do, and the immune system will keep getting "spiked", with potential further damage. I sincerely hope I am wrong :(
Check the latest study from Quatar regarding protection from infection and protection from severe disease for people who were never injected.
https://www.medrxiv.org/content/10.1101/2022.07.06.22277306v1
Regarding those who got injected once or twice but are hoping to get boosters from infection rather than another injection, there should be some good studies out of Israel, but i dont have them to hand at the moment.
Significant findings. Vaccine effects, on an average, do not last 4 months. The most important cohort now are those who have had infections and were also vaccinated at least thrice. Will this group in Qatar study them ? We need to know the overlapping influence of vaccines on the natural protection from primary infection. The clear biology. All that can be said now is that the vaccines effects would have disturbed the naturally obtained protection. Hybrid immunity in this case is a myth.
Good study, I saw DrBeen go through it. I am a great example of that. No vx. Had Covid april 21, not so mild and not so severe either. Got covid again Jan 22, Omicron most likely, hardly any symptoms. No lingering issues. Husband: vxd twice, got covid, got Epstein Barr Virus reactivation
If I understand you correctly, your point is that only sterilizing vaccines should be authorized under current circumstances to stop the viral transmission and to end the pandemic. And since the current vaccines induce non-neutralizing Abs that enhances the infection, the current vaccines should not be used. But, please be precise, because sterilizing and neutralizing are different concepts, and clinical trials are not limited to studies in lab.
I would still argue that the main problem with the vaccination against C19 has not been wrong vaccines designs, defective clinical trials, etc., but the problem has been unjustified vaccines mandates. There was well established case-law in the U.S. (Jacobson v. Massachusetts, etc.) and in the EU (Vavrička case) stating that only vaccines leading to herd immunity can be mandated. And it is well known that intramuscular vaccines can’t induce the necessary immune response in the upper respiratory tract against airborne respiratory virus to stop the transmission leading to herd immunity. But being aware of this knowledge the C19 vaccines were mandated, and mandates still enjoy protection when scrutinized in a judicial process. This is crazy.
With regard to vaccine design the S-directed immune response is justified approach. This is based on studies with SARS-CoV, which suggested that during natural infection body secreted primary S-directed Abs and T cells. And secondly, SARS-CoV-2 does not have much epitopes left to target with the vaccines because it is heavily glycosylated and conceals its epitopes. But still there are smarter vaccines design alternatives against SC2, which are not so financially-wise since they would serve to end the pandemic.
With regard to C-19 vaccine clinical trials there were significant defects in the protocols for the trials since drug agencies do not pay attention to population level dynamics of the viral evolution. Simple additions to vaccines trials would be sufficient (e.g. https://doi.org/10.1371%2Fjournal.pbio.3001000). And it is not possible to modulate the real-life pandemic conditions even in the lab with the most sophisticated AI. Therefore, clinical trials of pandemic drugs are going to mislead about real-time population-wide effects.
And if you argue about updated vaccines against new SC2 viral strains, there always remains the problem with original antigenic sin that was even an issue with Wuhan strain vaccines which did not prime new response by induced cross-reactive response from previous infections with HCoV-OC43 in many vaccinees.
I agree the mandates are unjustified, both by failure of effectiveness and lack of necessity.
Mandates are also illegal because you cannot do medical experiments on people without consent. The vaccines are experimental - none of them have completed even the "accelerated" phase 3 clinical trials, and they can never be completed now because of unblinding and injecting the control group.
Most importantly, proponents of the vaccines have failed to count serious adverse events caused by the vaccines during trials and delivery, and continue to deliberately mislead the public about it. There is still no assessment of long term risks, because studies were not done and pregnant women and kids are being injected despite never completing trials. Moreover, they have suppressed research and results of possible effective treatments. We simply cannot trust products and their proponents (corporate, government, scientific, medical) under such circumstances, at least until those responsible are held to account (unlikely in the near future).
"Sterilizing" was part of the definition until someone at the CDC decided to redefine the term itself (as if by doing so he could alter reality), so yeah.
I’ve found your videos very interesting and I’m keeping an open mind - I always like to weigh up all sides.
My personal position is that my fit and healthy wife was fine until she had her second vaccine. She works for the nhs so got them quite early (both Pfizer). As well as working for the nhs she was also a freelance fitness instructor at local gyms teaching mostly body pump and spin, quite often back to back. After the second vaccine she seemed to have overreactions to insect bites, developed shingles, was out of breath to the extent she couldn’t walk a small walk without getting out of breath. She’s currently under the long covid clinic and recently been diagnosed with rheumatoid arthritis. Maybe just coincidental but there do appear to be others with similar issues.
Keep doing your videos - I am disgusted with the way the majority of governments worldwide have treated the public like idiots and not allowed people to choose for themselves. My wife stood to lose her job (at least the threat) if she didn’t get vaccinated. She felt railroaded into getting it and can’t help but think if her health deterioration would have happened if she refused, as do I and the rest of the family.
So sorry to hear.🙏
Very unfortunate. Many families have such stories post vaccination. My studied hope is that these conditions will go away in time, especially since your wife was fit and active before. Let her get the standard treatments for whatever indications that crop up. Her Rheumatoid arthritic medicines might might clean up her residual viral load and help recovery in her other conditions. Most anti inflammatories are also anti virals and they could clear even the vaccine remnants, which are the pathogenic spike proteins. As an organic chemist, I am confident of the chemistry behind this hope. If you are in a position to visit South Africa, Dr. Chetty is your best hope. I would be following this sub stack for progress in her condition. God bless you both 🙏
Thank you Dr McMillan. I didn't really expect anything other than this prognosis. WE warned "them." "they" ignored and silenced US. Now we must continue to expose "them" and at the same time help the ONES' "they've" hurt. IMO "they" have been planning this for a very, very, very, long time. WE'RE doing GREAT! given that WE'VE only had 2+ years to figure this out. EVERYONE . . . ENDEAVEOR TO PERSEVER please.
The health of the host is paramount for efficient functioning of the immune system. Unhealthy people who ignore health, diet and lifestyle advice, and with high already inflammation markers are doubtless going to suffer more adverse effects from both the continued boosters and the repeated infections. Based on U.K. ONS stats we have already seen a 16% increase in all cause mortality in the past year, unrelated to Covid. These stats appear to be mirrored in other parts of the world where vaccination levels are high. This is going to be a case of survival of the fittest… maybe that’s not a bad thing either when you consider the pressure humans are putting on the planet!
It need not be more deaths if not for the vaccines.
COVID infection even among the people with comorbidities when treated early does not even require hospitalisation. The community across the globe has joined groups on Telegram and helped one another in getting remedies for early intervention and even for prophylaxis through simple vitamins such as Dr Zelenko and the FLCCC (flccc.net) had advised. We didn't wait for post 8th day for Dr Chetty's protocol because many people across the globe do not have access to doctors who dared to treat covid. Even many telehealth doctors in USA were not willing to prescribe medication of proper dosage and the group saw a few who ended up with severe covid and huge anxiety in the hospital, fighting hard to not be administered with Remdesivir. There were a few whose loved ones ended up in hospital and died as they were not aware of the early treatment protocols and the hospital refused them the therapeutics even when family printed out FLCCC's protocol for severe covid.
Many of us were able to not be at the mercy of doctors or hospitals. We took our vitamins or sunshine for those in non-temperate countries and stayed covid-free for the past 2 years.
Early treatment from day 1 of symptoms or even upon knowledge of exposure to covid works and we don't have autoimmune reactions or long covid.
Nasal and oral douce, gargle, spray with povidone iodine, or, hydrogen peroxide are also indispensable in the defence against disease.
This has precisely been my stand, early treatments ( from day 1, some URT symptoms) and common URT medicines. My earlier messaging was only through hundreds of newspaper letters and personal mails to known researchers in covid, including Dr. McMillan. Even though I have heard many of his videos before, only recently I could get into reading of his podcasts and the access to these comments columns. I am aware early treatments in covid was not an option with the doctors in the USA. A few days of safe OTC anti histamines like fexofenadine or Levocetrizine would have saved lot of hardships, including avoiding auto immune phases.
The West has not realised that covid like situations are best handled by clinicians and physicians at their patient level, sharing their work on appropriate social media. By continuing to let virologists, epidemiologists and administrators to control public response, they are sure to be hit by the tsunami next time. The entire world followed them in 2020 and early 2021 including the wait for vaccines. But many lesser countries saw the futility of this approach during the delta run in 2021, let the doctors and clinicians take over with early treatments and classical URT medicines like Azithromycin, Montelukast, Levocetrizine etc and have completely driven this virus into a hole. Next time, they won’t be stumped by auto immune presentations or whatever. They will hit the disease directly.
Thank you for your courage Dr. McMillan. It would seem we are all down stream on this one.
"There are options available, but requires current scientific leadership to step back and allow others to lead. Not sure this will happen, and the outcomes could be disastrous."
I am 100% sure it will not happen, and 90% sure the outcome will be disastrous - it's just a matter of scale and timing.
https://www.pnas.org/doi/10.1073/pnas.2203760119#sec-3
The emergence of SARS-CoV-2 variants with enhanced transmissibility, pathogenesis, and resistance to vaccines presents urgent challenges for curbing the COVID-19 pandemic. While Spike mutations that enhance virus infectivity or neutralizing antibody evasion may drive the emergence of these novel variants, studies documenting a critical role for interferon responses in the early control of SARS-CoV-2 infection,
Viruses are obligate parasites that rely on host cell synthesis machinery to replicate. A major advancement in the field of chronobiology is the realization that host susceptibility to an infectious agent is not only dependent on the viral inoculum size, transmission route and length of exposure, but on the time of day when the pathogen is encountered. Multiple studies have demonstrated that many viruses are directly or indirectly influenced by the circadian-regulated pathway's
Viruses are obligate parasites that rely on host cell synthesis machinery to replicate. A major advancement in the field of chronobiology is the realization that host susceptibility to an infectious agent is not only dependent on the viral inoculum size, transmission route and length of exposure, but on the time of day when the pathogen is encountered. Multiple studies have demonstrated that many viruses are directly or indirectly influenced by the circadian-regulated pathway's
APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients
https://pubmed.ncbi.nlm.nih.gov/33104521/
Short telomeres increase the risk of severe COVID-19
Some evidence indicates that DPP-4 inhibitors might inhibit the entrance of coronavirus into the airways, which suggests an additional therapeutic approach to COVID-19 treatment
https://link.springer.com/article/10.1007/s00592-020-01539-z
Coagulation problems have also been seen in post-COVID-19 survivors and in PPCS patients, to whom anticoagulants are routinely prescribed. Despite the variety and significance of the symptoms reported by numerous COVID-19 survivors with or without PPCS, valuable biomolecular markers to monitor this condition are still lacking.
I agree