The next COVID-19 pandemic clinical presentations will appear confusing without an understanding of the autoimmune nature of the disease. While scientific opinions may be silenced, predicted outcomes will still occur. Science does not care about politics.
The description of the problem is rather correct. But the scope of the problem is rather not. This will not be a tsunami, I hope. The hope is based on the following considerations:
- SARS-CoV-2 shall become non-antigenic to vaccinal S-specific memory B and T cell via glycosylation and not be means of protein changes. Epitopes shall remain the same, but the epitopes shall not be reached. There will be limited vaccinal immune response against the new strains of the virus and this shall trigger/require training of innate immunity, that is the only instrument out of endless pandemic.
- vaccinal S-specific memory B cells are long lived plasma blasts not long-lived bone marrow plasma cells. Therefore, vaccinal priming is not irreversible. Post 12-months period after final boost there should be no vaccinal B cells in a majority of vaccinated cohort, I hope. Therfore, ADEI is not life-long risk.
- There should be limited number of non-infected vaccinees. Therefore, even vaccinees have primed immune response (B and T cell) against M, N, E and some nonstructural and accessory proteins, sufficient to avoid autoimmune reactions.
- Phagocytoses, NK cell cytotoxic activity, even vaccinal Abs cytolytic activity all can be sufficient to recognise, neutralize and clear the antigen before it causes adverse effects.
Do not focus so much on threats and weaknesses. Look to strengths and opportunities for objective SWOT analysis of the pandemic. Do not underestimate the innate immunity like vaccinees do. The nature tends to preserve a balance between the pathogen and the host. We shall see, if the host lets the nature to solve the problems its created.
I’ve found your videos very interesting and I’m keeping an open mind - I always like to weigh up all sides.
My personal position is that my fit and healthy wife was fine until she had her second vaccine. She works for the nhs so got them quite early (both Pfizer). As well as working for the nhs she was also a freelance fitness instructor at local gyms teaching mostly body pump and spin, quite often back to back. After the second vaccine she seemed to have overreactions to insect bites, developed shingles, was out of breath to the extent she couldn’t walk a small walk without getting out of breath. She’s currently under the long covid clinic and recently been diagnosed with rheumatoid arthritis. Maybe just coincidental but there do appear to be others with similar issues.
Keep doing your videos - I am disgusted with the way the majority of governments worldwide have treated the public like idiots and not allowed people to choose for themselves. My wife stood to lose her job (at least the threat) if she didn’t get vaccinated. She felt railroaded into getting it and can’t help but think if her health deterioration would have happened if she refused, as do I and the rest of the family.
Thank you Dr McMillan. I didn't really expect anything other than this prognosis. WE warned "them." "they" ignored and silenced US. Now we must continue to expose "them" and at the same time help the ONES' "they've" hurt. IMO "they" have been planning this for a very, very, very, long time. WE'RE doing GREAT! given that WE'VE only had 2+ years to figure this out. EVERYONE . . . ENDEAVEOR TO PERSEVER please.
The health of the host is paramount for efficient functioning of the immune system. Unhealthy people who ignore health, diet and lifestyle advice, and with high already inflammation markers are doubtless going to suffer more adverse effects from both the continued boosters and the repeated infections. Based on U.K. ONS stats we have already seen a 16% increase in all cause mortality in the past year, unrelated to Covid. These stats appear to be mirrored in other parts of the world where vaccination levels are high. This is going to be a case of survival of the fittest… maybe that’s not a bad thing either when you consider the pressure humans are putting on the planet!
It need not be more deaths if not for the vaccines.
COVID infection even among the people with comorbidities when treated early does not even require hospitalisation. The community across the globe has joined groups on Telegram and helped one another in getting remedies for early intervention and even for prophylaxis through simple vitamins such as Dr Zelenko and the FLCCC (flccc.net) had advised. We didn't wait for post 8th day for Dr Chetty's protocol because many people across the globe do not have access to doctors who dared to treat covid. Even many telehealth doctors in USA were not willing to prescribe medication of proper dosage and the group saw a few who ended up with severe covid and huge anxiety in the hospital, fighting hard to not be administered with Remdesivir. There were a few whose loved ones ended up in hospital and died as they were not aware of the early treatment protocols and the hospital refused them the therapeutics even when family printed out FLCCC's protocol for severe covid.
Many of us were able to not be at the mercy of doctors or hospitals. We took our vitamins or sunshine for those in non-temperate countries and stayed covid-free for the past 2 years.
Early treatment from day 1 of symptoms or even upon knowledge of exposure to covid works and we don't have autoimmune reactions or long covid.
The West has not realised that covid like situations are best handled by clinicians and physicians at their patient level, sharing their work on appropriate social media. By continuing to let virologists, epidemiologists and administrators to control public response, they are sure to be hit by the tsunami next time. The entire world followed them in 2020 and early 2021 including the wait for vaccines. But many lesser countries saw the futility of this approach during the delta run in 2021, let the doctors and clinicians take over with early treatments and classical URT medicines like Azithromycin, Montelukast, Levocetrizine etc and have completely driven this virus into a hole. Next time, they won’t be stumped by auto immune presentations or whatever. They will hit the disease directly.
"There are options available, but requires current scientific leadership to step back and allow others to lead. Not sure this will happen, and the outcomes could be disastrous."
I am 100% sure it will not happen, and 90% sure the outcome will be disastrous - it's just a matter of scale and timing.
The emergence of SARS-CoV-2 variants with enhanced transmissibility, pathogenesis, and resistance to vaccines presents urgent challenges for curbing the COVID-19 pandemic. While Spike mutations that enhance virus infectivity or neutralizing antibody evasion may drive the emergence of these novel variants, studies documenting a critical role for interferon responses in the early control of SARS-CoV-2 infection,
Viruses are obligate parasites that rely on host cell synthesis machinery to replicate. A major advancement in the field of chronobiology is the realization that host susceptibility to an infectious agent is not only dependent on the viral inoculum size, transmission route and length of exposure, but on the time of day when the pathogen is encountered. Multiple studies have demonstrated that many viruses are directly or indirectly influenced by the circadian-regulated pathway's
Viruses are obligate parasites that rely on host cell synthesis machinery to replicate. A major advancement in the field of chronobiology is the realization that host susceptibility to an infectious agent is not only dependent on the viral inoculum size, transmission route and length of exposure, but on the time of day when the pathogen is encountered. Multiple studies have demonstrated that many viruses are directly or indirectly influenced by the circadian-regulated pathway's
Some evidence indicates that DPP-4 inhibitors might inhibit the entrance of coronavirus into the airways, which suggests an additional therapeutic approach to COVID-19 treatment
Coagulation problems have also been seen in post-COVID-19 survivors and in PPCS patients, to whom anticoagulants are routinely prescribed. Despite the variety and significance of the symptoms reported by numerous COVID-19 survivors with or without PPCS, valuable biomolecular markers to monitor this condition are still lacking.
The description of the problem is rather correct. But the scope of the problem is rather not. This will not be a tsunami, I hope. The hope is based on the following considerations:
- SARS-CoV-2 shall become non-antigenic to vaccinal S-specific memory B and T cell via glycosylation and not be means of protein changes. Epitopes shall remain the same, but the epitopes shall not be reached. There will be limited vaccinal immune response against the new strains of the virus and this shall trigger/require training of innate immunity, that is the only instrument out of endless pandemic.
- vaccinal S-specific memory B cells are long lived plasma blasts not long-lived bone marrow plasma cells. Therefore, vaccinal priming is not irreversible. Post 12-months period after final boost there should be no vaccinal B cells in a majority of vaccinated cohort, I hope. Therfore, ADEI is not life-long risk.
- There should be limited number of non-infected vaccinees. Therefore, even vaccinees have primed immune response (B and T cell) against M, N, E and some nonstructural and accessory proteins, sufficient to avoid autoimmune reactions.
- Phagocytoses, NK cell cytotoxic activity, even vaccinal Abs cytolytic activity all can be sufficient to recognise, neutralize and clear the antigen before it causes adverse effects.
Do not focus so much on threats and weaknesses. Look to strengths and opportunities for objective SWOT analysis of the pandemic. Do not underestimate the innate immunity like vaccinees do. The nature tends to preserve a balance between the pathogen and the host. We shall see, if the host lets the nature to solve the problems its created.
I’ve found your videos very interesting and I’m keeping an open mind - I always like to weigh up all sides.
My personal position is that my fit and healthy wife was fine until she had her second vaccine. She works for the nhs so got them quite early (both Pfizer). As well as working for the nhs she was also a freelance fitness instructor at local gyms teaching mostly body pump and spin, quite often back to back. After the second vaccine she seemed to have overreactions to insect bites, developed shingles, was out of breath to the extent she couldn’t walk a small walk without getting out of breath. She’s currently under the long covid clinic and recently been diagnosed with rheumatoid arthritis. Maybe just coincidental but there do appear to be others with similar issues.
Keep doing your videos - I am disgusted with the way the majority of governments worldwide have treated the public like idiots and not allowed people to choose for themselves. My wife stood to lose her job (at least the threat) if she didn’t get vaccinated. She felt railroaded into getting it and can’t help but think if her health deterioration would have happened if she refused, as do I and the rest of the family.
Thank you Dr McMillan. I didn't really expect anything other than this prognosis. WE warned "them." "they" ignored and silenced US. Now we must continue to expose "them" and at the same time help the ONES' "they've" hurt. IMO "they" have been planning this for a very, very, very, long time. WE'RE doing GREAT! given that WE'VE only had 2+ years to figure this out. EVERYONE . . . ENDEAVEOR TO PERSEVER please.
The health of the host is paramount for efficient functioning of the immune system. Unhealthy people who ignore health, diet and lifestyle advice, and with high already inflammation markers are doubtless going to suffer more adverse effects from both the continued boosters and the repeated infections. Based on U.K. ONS stats we have already seen a 16% increase in all cause mortality in the past year, unrelated to Covid. These stats appear to be mirrored in other parts of the world where vaccination levels are high. This is going to be a case of survival of the fittest… maybe that’s not a bad thing either when you consider the pressure humans are putting on the planet!
It need not be more deaths if not for the vaccines.
COVID infection even among the people with comorbidities when treated early does not even require hospitalisation. The community across the globe has joined groups on Telegram and helped one another in getting remedies for early intervention and even for prophylaxis through simple vitamins such as Dr Zelenko and the FLCCC (flccc.net) had advised. We didn't wait for post 8th day for Dr Chetty's protocol because many people across the globe do not have access to doctors who dared to treat covid. Even many telehealth doctors in USA were not willing to prescribe medication of proper dosage and the group saw a few who ended up with severe covid and huge anxiety in the hospital, fighting hard to not be administered with Remdesivir. There were a few whose loved ones ended up in hospital and died as they were not aware of the early treatment protocols and the hospital refused them the therapeutics even when family printed out FLCCC's protocol for severe covid.
Many of us were able to not be at the mercy of doctors or hospitals. We took our vitamins or sunshine for those in non-temperate countries and stayed covid-free for the past 2 years.
Early treatment from day 1 of symptoms or even upon knowledge of exposure to covid works and we don't have autoimmune reactions or long covid.
The West has not realised that covid like situations are best handled by clinicians and physicians at their patient level, sharing their work on appropriate social media. By continuing to let virologists, epidemiologists and administrators to control public response, they are sure to be hit by the tsunami next time. The entire world followed them in 2020 and early 2021 including the wait for vaccines. But many lesser countries saw the futility of this approach during the delta run in 2021, let the doctors and clinicians take over with early treatments and classical URT medicines like Azithromycin, Montelukast, Levocetrizine etc and have completely driven this virus into a hole. Next time, they won’t be stumped by auto immune presentations or whatever. They will hit the disease directly.
Thank you for your courage Dr. McMillan. It would seem we are all down stream on this one.
"There are options available, but requires current scientific leadership to step back and allow others to lead. Not sure this will happen, and the outcomes could be disastrous."
I am 100% sure it will not happen, and 90% sure the outcome will be disastrous - it's just a matter of scale and timing.
https://www.pnas.org/doi/10.1073/pnas.2203760119#sec-3
The emergence of SARS-CoV-2 variants with enhanced transmissibility, pathogenesis, and resistance to vaccines presents urgent challenges for curbing the COVID-19 pandemic. While Spike mutations that enhance virus infectivity or neutralizing antibody evasion may drive the emergence of these novel variants, studies documenting a critical role for interferon responses in the early control of SARS-CoV-2 infection,
Viruses are obligate parasites that rely on host cell synthesis machinery to replicate. A major advancement in the field of chronobiology is the realization that host susceptibility to an infectious agent is not only dependent on the viral inoculum size, transmission route and length of exposure, but on the time of day when the pathogen is encountered. Multiple studies have demonstrated that many viruses are directly or indirectly influenced by the circadian-regulated pathway's
Viruses are obligate parasites that rely on host cell synthesis machinery to replicate. A major advancement in the field of chronobiology is the realization that host susceptibility to an infectious agent is not only dependent on the viral inoculum size, transmission route and length of exposure, but on the time of day when the pathogen is encountered. Multiple studies have demonstrated that many viruses are directly or indirectly influenced by the circadian-regulated pathway's
APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients
https://pubmed.ncbi.nlm.nih.gov/33104521/
Short telomeres increase the risk of severe COVID-19
Some evidence indicates that DPP-4 inhibitors might inhibit the entrance of coronavirus into the airways, which suggests an additional therapeutic approach to COVID-19 treatment
https://link.springer.com/article/10.1007/s00592-020-01539-z
Coagulation problems have also been seen in post-COVID-19 survivors and in PPCS patients, to whom anticoagulants are routinely prescribed. Despite the variety and significance of the symptoms reported by numerous COVID-19 survivors with or without PPCS, valuable biomolecular markers to monitor this condition are still lacking.
I agree