Hard for me to believe from what I’ve watched from your work and from the fact that there is silence on the disaster ous outcomes of these genetic manipulating vaccines there there wasn’t intent. Never taking another’s vaccine again. Lost all faith in our medical system.
Sorry Dr MacMillan for all these weird, rude comments from some, just ignore and know most of us listening are enjoying learning from you and greatly appreciate your continued deep dive to find the truth!
Dr McMillan, thank you for sharing your research and thoughts. As to the "animal venom components", take a look at Dr. Brian Ardis research. He speaks on these venom components and lab made components that are similar. Very enlightening.
I fully agree with you, especially when you said: Two Epidemics One Visible, One Brewing. No reason why, when we can defend ourselves with optimal nutrition and Magnesium Glycinate and Liposomal Vitamin C and D3 with K2-MK7.
Dr Phil, it’s safe for you to say “there was intent”. There was and continues to be. Please stop hiding from the truth and protecting “them.” It discredits your fine work.
In a medical context, "contraindicative" means a situation or factor that makes a specific treatment or procedure inadvisable because it could be harmful to the patient.
Here's a more detailed explanation:
Definition:
A contraindication is a condition, symptom, or factor that suggests a medical treatment or procedure should be avoided because it could potentially cause harm.
Opposite of Indication:
Contraindication is the opposite of "indication," which refers to a reason or situation that suggests a medical treatment or procedure is appropriate.
Types of Contraindications:
Absolute contraindication: A situation where a treatment or procedure must be avoided under any circumstances because it could be life-threatening.
Relative contraindication: A situation where caution should be exercised when using a particular treatment or procedure, as the potential risks and benefits need careful consideration.
A chinese communist party/people's liberation army (ccp/pla) STEALTH, 2 front, "Unrestricted Warfare", "economic war", bioweapon attack on the west.
Front #1) sars-cov-2 "delivery vehicle" with selected bioweapon inserts + "developed" immune escape variants with selected bioweapon inserts,
Front #2) ccp/pla tradecraft + FEAR! FEAR! FEAR!-inducing showmanship inducing the west to both shut down their economies and force mass "vaccination" using the ccp/pla slow kill bioweapon spike genetic code to program the west's mRNA and viral vector "vaccine" platforms to now make ccp/pla slow kill "agent spike" vaccine antigens - in the Trillions per injection.
Okay, I waited for you publishing this yesterday video on your substack. So I‘ll ask again: Where can the sheets be found where these ORFs are discribed? On the website of Pure Media Australia (PME) I can‘t see them.
I still do not fully believe that these ORFs are embedded in the genomic code of the mRNA-Spike. One thing I find very strange: You are always speeking of this unknown ORF10. But in videos of PME (meanwhile their series consists of 8 videos!) they never mention ORF10. I know, you are always claiming that the function is unknown. But why are you repeatedly mentioning it?
I see strong evidence for the spike as being the monster created by some weird Frankenstein. I understand the role of the ORFs in INFECTION. But where is the proof that ORFs (??????) are lying within the engineered spike? Please, help me in understanding. And - if possible - provide the papers about ORFs you quoted. Thank you, Philip.
I am suffering from long covid(non-vaxxed). I am being treated by The Leading Edge Clinic and tested positive for spike proteins and micro clots. Could the shedding from the vaccinated be the cause of my chronic illnesses?
Sad to here. So you got LC after covid. No, the virus on itsel suffices for this tragedy to happen. I still do not quite get what the people from PME (Pure Media Australia) want to say in detail with their videos. But today I watched the video covering an interview with „their“ chemist (Greg …something), uploaded in December 2024. This is very informativ - and scary….
She investigated and noised abroad the tight binding of Spike-NTD with the host's fibrinogen. Her conclusion that this is a viral strategy for immune system evasion did not and does not ring true to me. Perhaps immune system evasion as a secondary effect of enhancing Spike-NTD binding in the bioweapon lab for the purpose of initiating / enhancing the multiple clotting pathways, for all manner of clotting - from clotting initiated via spike injury to the lining of the blood vessels to spike bound platelet microclotting to prion initiated cascades to amyloid in clots to "white clots" to perhaps even some day "vaccine" antibody initiated clotting. All pieces of the puzzle of covid and covid vaccine caused clotting that scientists and clinicians from around the world have revealed.
I can now add tight binding of Spike-NTD with the host's fibrinogen into the mix as per below.
Unveiling the Persistent Mystery of Unusual Clots and the Urgent Need for Scientific Inquiry.
Dr Philip McMillan
Jul 20, 2024
Now adding into the previously posted "white clot mix" below this reference which Dr McMillan reported on - Joe Lee JJ - CLIP 01 - Antigen String Theory Dr. Joe Lee interviewed on gigaohmBiological starting at 0:15 into the video if you choose to avoid the "mu sick" here https://x.com/super_spreaders/status/1715220043108069819
Various spike site specific antibodies (up to 17 trillion antibodies in response to a covid "vaccine" - see new comment below) my note: creating harms, each attaching at various antigenic sites on the "vaccine" spike antigen, antibodies and spike antigens linking together with other antibody/antigen complexes creating a latticework of antigen and antibodies initiating clotting / initiating a latticework for clotting to form on or around.
previously posted comment Liked by Dr Philip McMillan new comment below this reposted comment
Report on what Dr. Ryan Cole observed in white clots through his microscope - fibrin, platelets and amyloid and a little bit of how this could come to be. youtube video "Latest Research Findings on Embalmers Strange Clots" by Vejon Health https://www.youtube.com/watch?v=S4Q-vW1tWyo Update from Thomas Haviland MSc at the 53:53 time to 54:42 mark
my note: spike protein has been seen throughout these white clots
my note: prion initiating site "insert" in the spike and interaction between prion initiation and amyloid formation
my note: "CD147, a transmembrane glycoprotein, is expressed on all leukocytes, platelets, and endothelial cells."
my note: spike attaches to CD147 on platelets and can clump platelets together
my note: spike attaching to CD147 on endothelial cells. initiating injury activating a cascade to fibrin
note: wickedpedia - "Fibrinogen is a glycoprotein complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood clot. Fibrin clots function primarily to occlude blood vessels to stop bleeding. Fibrin also binds and reduces the activity of thrombin"
note: up to 3 trillion whole spike "vaccine" antigens "created" per injection of mRNA or viral vector "vaccinations". see below
note: Amyloid from spike - 2 of many studies - "Towards the emergence of a new form of the neurodegenerative Creutzfeldt-Jakob disease: Twenty six cases of CJD declared a few days after a COVID-19 vaccine Jab" Also now being reported to be a S2 subunit "feature" in certain Omicron. "SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy"
One of the actions of ivermectin is reported to be binding to CD147 which then prevents spike adhesion to the ivermectin bound CD147. (David E. Scheim, PhD) This is a action of ivermectin which makes the re-profusion drug application of 100 mg dose of ivermectin so effective in the intermediary (before hardening into clots) covid blood "clumping" stage seen here. See Dr. Jackie Stone discuss her own severe covid episode in part 4 of 5 of "The patient experience of ivermectin" (8 minute 22 second video segment)
A 100 mg dose of Ivermectin as Dr. Jackie Stone in Zimbabwe took when, from covid infection from the South African strain, her blood oxygen was declining, her blood "clumping" leading to micro clotting to "clotting out". A life saving 100mg dose which caused temporary visual "wave pool" side effects to which Dr Jackie stone replied "Excellent, I've had enough". Dr. Jackie Stone's account is here https://medicalupdateonline.com/2021/04/the-patient-experience-of-ivermectin/
Thanks to David Scheim, Ph.D. (MIT) and Dr Jackie Stone we know "I" can be used as a covid times re-profusion treatment. A Nov 18, 2020 "Discussion with Dr David Scheim about the effects of Vascular Occlusion during COVID". can be seen here https://www.youtube.com/watch?v=4h2nO4wMRis at the youtube channel HIBBERD HEALTH by Jennifer Hibberd, also one of our covid times heros.This is the most important discussion about the most important anti blood clumping action of and dosing and safety of Ivermectin that I found.
One of the actions of ivermectin is reported to be binding to sialic acid receptors on red blood cells (and CD147 on platelets) which then prevents spike adhesion to the ivermectin bound receptors (David E. Scheim, PhD) This is a action of ivermectin which makes the re-profusion drug application of 100 mg dose of ivermectin so effective in the intermediary (before hardening into clots) covid blood "clumping" stage
New comment - My comments/replies, edited, which were posted to Steve Kirsch's research article on substack "VAERS data shows Moderna causes 30% more deaths per dose than Pfizer"
Thank You for this work. It seemed to me that the pfizer shot had received much more of the reporting undertaken by those revealing The Truth of covid "vaccine" harms than had moderna.
Almost as if moderna had some "special" protection suppressing The Truth of greater moderna harms, as would be expected, with the much higher moderna load of nano-particles with potentially higher levels of harmful spike and harmful antibodies produced
up to 17 trillion antibodies* (my note: causing all manner of harms) produced by the body in response an estimated 10 billion, 40 billion, 50 billion lipid nanoparticles or viral vectors per injection for pfizer, moderna, astrazeneca respectively causing the body to produce up to 3 trillion* whole spike antigens produced per injection *Ogata et al - Marc Girardot is the one who did the gumshoe work parsing these figures out of studies.
from "Karl" Are you sure of those numbers?.... This is an INSANE amount
I got the numbers from replies Marc Girardot sent to my comments and from his substack. As best as I could. So to answer your question "Are you sure of those numbers?" I say this is what I have found so far - actual "for sure" numbers? hard for me to locate with the short search I did. I trust Marc Girardot made a better search, accepting that understandings vary. i.e. from all I have read and heard I understand sars-cov-2 is a "delivery vehicle" for toxic bioweapon spike as are "vaccine" platforms. I understand Marc Girardot questions the "toxic" nature of spike.
I AM SURE that I made the right decision in electing Real Prevention with Real Early Treatment backup instead of an Emergency Use Authorization "vaccine".
His article is titled "What happens to those billions of NanoParticles you've become host to? [Revisited]" here https://covidmythbuster.substack.com/p/what-happens-to-those-billions-of-804 these are quotes from that post - "up to 50 billion viral vectors for AstraZeneca, 40 billion LNPs for Moderna, and likely 10 for Pfizer" and "a study by Harvard Medical: Ogata et al. that detected a maximum level of around 3 trillion spikes at Day 5." and from what source?"17,000 trillion antibodies." (note: new antibody harms "string theory" here https://x.com/super_spreaders/status/1715220043108069819 "string theory") and "Those are numbers way beyond very severe SARS-COV-2 infections: typically at infection peak between 1 and 100 billion virions, are present in the body."
KarlM Alias
Yes, it is strange. It is also strange that so few, on our side, have even mentioned the numbers which I thought would have been a good argument to try and red-pill. ... It would be good for this to get sorted out.
my reply: the thought of billions of my own cells converted to mRNA or viral vector fueled spike factories to then, my own cells, be marked for destruction by my own immune system (thoughts of autoimmune disease) then to be attacked and destroyed by my own immune system .... .
these thoughts and more helped to red-pill me
Yes. "numbers ... .. a good argument to try and red-pill."
Attachments area
Preview YouTube video Latest Research Findings on Embalmers Strange Clots
below is the post that "the below" found "so utterly stupid"
Will R Thomson
Will’s Newsletter
13h
"This article is so utterly stupid. it says "nobody had an answer as to why sarscov2 caused clotting and heart issues". That's classing bullshit gaslighting by another arsehole doctor right there, declaring because she is stupid, everyone else is stupid."
Another piece of the big picture - "Spike-NTD binds with the host fibrinogen"
natural? or bioweapon engineering to induce sars-cov2 fast and slow kill clotting features?
A hidden strategy: How SARS-CoV-2 uses fibrinogen to evade the immune system
A hidden strategy: How SARS-CoV-2 uses fibrinogen to evade the immune system
by Parth Sarthi Sen Gupta
This cover art depicts SARS-CoV-2's novel immune escape strategy, where Spike-NTD binds with the host fibrinogen, shielding the virus from NTD-directed antibodies and facilitating immune evasion. Credit: Parth Sarthi Sen Gupta
As scientists, we often think we understand a virus—its structure, its tricks, the way it moves through the body. But every once in a while, we stumble upon something unexpected—something that completely changes the way we see an infection.
I have spent years studying the molecular tactics of viruses—how they invade, replicate, and most intriguingly, how they evade our immune system. Some strategies are well documented: antigenic drift, glycan shielding, immune suppression. But every so often, we stumble upon a novel mechanism that redefines our understanding of viral pathogenesis.
A recent finding in Nature showed that the spike protein of SARS-CoV-2 binds with fibrinogen, leading to thrombo-inflammation. This raises a fundamental question: Why does the virus need to bind with fibrinogen? Could this interaction provide an evolutionary advantage to the virus? Could this be the reason behind post-COVID heart attack cases?
In our recent study, published in ACS Pharmacology & Translational Science, we found that SARS-CoV-2, the virus that causes COVID-19, has a sneaky way of escaping immune detection. It binds to fibrinogen, a key protein involved in blood clotting with stronger affinity than antibodies. This interaction not only helps the virus evade immune cells but may also contribute to the dangerous clotting issues seen in severe COVID-19 cases. This finding could change how we think about the virus and how we treat it.
The mystery of COVID-19, blood clots and immune escape
When COVID-19 first emerged, most people focused on its impact on the lungs. But soon, doctors started reporting something unusual—many critically ill patients were developing blood clots, leading to strokes, heart attacks and organ failure. This was strange because viral infections don't typically cause widespread clotting issues.
For months, researchers tried to understand why. Some thought it was due to excessive inflammation, while others suspected direct viral damage to blood vessels. But no one had a clear answer.
That's when we decided to look at fibrinogen, one of the most important proteins involved in blood clotting. Our study revealed that the γ-chain demonstrates a higher binding affinity for the NTD domain compared to the neutralizing antibodies, providing striking insights and suggesting that the virus had evolved a mechanism to preferentially bind to fibrinogen rather than the neutralizing antibodies.
Fibrinogen acts like glue, helping platelets stick together to form clots when needed. But what if SARS-CoV-2 had found a way to exploit this system? We proposed the Dual Immune Evasion Strategy of the virus:
Mutating the receptor binding domain (RBD) of the spike protein: The virus introduces mutations in the RBD region of the spike protein to escape neutralizing antibodies targeted against it.
Fibrinogen binding to N-terminal domain (NTD) of spike: To protect the more conserved NTD, the virus interacts with fibrinogen, protecting the NTD region from antibody recognition.
This dual strategy of SARS-CoV-2 helps it to maintain infectivity while escaping the host immunity.
A) 3D conformation of the spike NTD bound to the γ-chain of fibrinogen (docked conformation), along with S2M28 (PDB ID: 7LY0) and SARS2-57 (PDB ID: 7SWW). B) Surface diagram showing the binding of spike NTD to the γ-chain of fibrinogen, S2M28, and SARS2-57, highlighting the similar interacting orientations of the three. C) MMGBSA binding free energy comparison for the γ-chain of fibrinogen and neutralizing antibodies (S2M28, SARS2-57, and 4A8). Credit: ACS Pharmacology & Translational Science (2025). DOI: 10.1021/acsptsci.5c00122
Implications for immune evasion and pathogenesis
Viruses are masterful at exploiting host systems. HIV hides within host cells; influenza frequently mutates its surface proteins; and now, we see that SARS-CoV-2 might be leveraging fibrinogen as a molecular cloak.
Fibrinogen is known to interact with immune cells, particularly neutrophils and macrophages, through integrin receptors. By binding fibrinogen, the spike protein might be interfering with normal immune signaling, preventing efficient recognition and clearance of the virus. This could contribute to prolonged viral persistence in some patients, leading to chronic or severe disease.
Additionally, this interaction might explain why some COVID-19 patients develop severe inflammatory and coagulation-related complications. If spike-fibrinogen binding alters clotting dynamics, it could be a driving factor behind the thrombotic events seen in critical cases. Understanding this mechanism gives us a new target for potential therapeutic interventions.
Looking forward: What this means for treatment and prevention
Our finding raises important questions: Can we block the spike-fibrinogen interaction to reduce disease severity? Could fibrinogen levels serve as a biomarker for predicting COVID-19 complications? And, most critically, does this mechanism play a role in other emerging variants?
One possible therapeutic avenue is developing small molecules or monoclonal antibodies that disrupt spike-fibrinogen binding. By preventing this interaction, we might be able to restore normal immune function and reduce clotting risks in severe patients.
Additionally, our findings emphasize the need to look beyond traditional receptor interactions when studying viral immune evasion. If SARS-CoV-2 can manipulate host proteins like fibrinogen, what other molecular partnerships remain undiscovered? This study serves as a stepping stone for deeper investigations into the interplay between viral proteins and host immune factors.
A personal perspective
Scientific discovery is often a mix of persistence and serendipity. When we began this study, we weren't looking for an immune evasion mechanism—we were searching for the reason behind the fibrinogen binding. But as the data unfolded, it became clear that we had uncovered something bigger.
As a computational biologist, I have always been fascinated by the unseen molecular dialogues between viruses and host cells. The fact that a virus can exploit a key clotting protein to evade immune detection is both astonishing and humbling. It's a reminder that, despite our scientific advancements, nature still holds secrets waiting to be unraveled.
Conclusion
Our study on the spike-fibrinogen interaction reveals a novel immune escape strategy of SARS-CoV-2, with potential implications for disease severity and treatment. By binding fibrinogen, the virus not only disrupts normal clotting but may also evade immune surveillance, contributing to prolonged infection and severe inflammatory responses.
Understanding these molecular interactions is crucial for developing targeted therapies. As we continue to study the intricate battle between SARS-CoV-2 and the immune system, one thing is clear: The virus is a formidable opponent, but with deeper insight, we can develop strategies to counter its tricks.
Science, at its core, is about uncovering the unknown. This discovery is just one piece of the puzzle, but it brings us closer to understanding—and ultimately defeating—the virus that has reshaped our world.
This story is part of Science X Dialog, where researchers can report findings from their published research articles. Visit this page for information about Science X Dialog and how to participate.
More information: Saroj Kumar Panda et al, Spike Protein–Fibrinogen Interaction: A Novel Immune Evasion Strategy of SARS-CoV-2?, ACS Pharmacology & Translational Science (2025). DOI: 10.1021/acsptsci.5c00122
Dr. Parth Sarthi Sen Gupta is an associate professor in the School of Biosciences and Bioengineering, D Y Patil International University. He has published more than 50 research articles and book chapters in reputed peer reviewed journals. He is a computational biologist working on designing and developing therapeutics against various diseases. His research work on COVID-19 has been highlighted by various national and international news agencies and recognized by world health organizations.
Explore further
Predicting SARS-CoV-2 variant infectivity with biophysical principles
Hard for me to believe from what I’ve watched from your work and from the fact that there is silence on the disaster ous outcomes of these genetic manipulating vaccines there there wasn’t intent. Never taking another’s vaccine again. Lost all faith in our medical system.
Of course there was INTENT.
Very good intentions... https://fasteddynz.substack.com/p/the-ultimate-extinction-plan-uep
This will prevent this https://fasteddynz.substack.com/p/collapse-and-cannibalism
No wonder nobody who could push back... has pushed back.
There is CONSENSUS
I'm wondering if anyone has explored the effect of an intense burst of extra high frequency 5G on vaccinated blood ?
Sorry Dr MacMillan for all these weird, rude comments from some, just ignore and know most of us listening are enjoying learning from you and greatly appreciate your continued deep dive to find the truth!
The evil ones made this bioweapon for evil intent, if they didn’t they would have pulled it of the market long ago.
Dr McMillan, thank you for sharing your research and thoughts. As to the "animal venom components", take a look at Dr. Brian Ardis research. He speaks on these venom components and lab made components that are similar. Very enlightening.
I fully agree with you, especially when you said: Two Epidemics One Visible, One Brewing. No reason why, when we can defend ourselves with optimal nutrition and Magnesium Glycinate and Liposomal Vitamin C and D3 with K2-MK7.
R/
Dr Lucks PhD Nutrition Scientist
Dr Phil, it’s safe for you to say “there was intent”. There was and continues to be. Please stop hiding from the truth and protecting “them.” It discredits your fine work.
Where is the scientific proof that these ORF genetic templates are engineered into the genetic structure for spike protein?
AI Overview
In a medical context, "contraindicative" means a situation or factor that makes a specific treatment or procedure inadvisable because it could be harmful to the patient.
Here's a more detailed explanation:
Definition:
A contraindication is a condition, symptom, or factor that suggests a medical treatment or procedure should be avoided because it could potentially cause harm.
Opposite of Indication:
Contraindication is the opposite of "indication," which refers to a reason or situation that suggests a medical treatment or procedure is appropriate.
Types of Contraindications:
Absolute contraindication: A situation where a treatment or procedure must be avoided under any circumstances because it could be life-threatening.
Relative contraindication: A situation where caution should be exercised when using a particular treatment or procedure, as the potential risks and benefits need careful consideration.
A chinese communist party/people's liberation army (ccp/pla) STEALTH, 2 front, "Unrestricted Warfare", "economic war", bioweapon attack on the west.
Front #1) sars-cov-2 "delivery vehicle" with selected bioweapon inserts + "developed" immune escape variants with selected bioweapon inserts,
Front #2) ccp/pla tradecraft + FEAR! FEAR! FEAR!-inducing showmanship inducing the west to both shut down their economies and force mass "vaccination" using the ccp/pla slow kill bioweapon spike genetic code to program the west's mRNA and viral vector "vaccine" platforms to now make ccp/pla slow kill "agent spike" vaccine antigens - in the Trillions per injection.
Okay, I waited for you publishing this yesterday video on your substack. So I‘ll ask again: Where can the sheets be found where these ORFs are discribed? On the website of Pure Media Australia (PME) I can‘t see them.
I still do not fully believe that these ORFs are embedded in the genomic code of the mRNA-Spike. One thing I find very strange: You are always speeking of this unknown ORF10. But in videos of PME (meanwhile their series consists of 8 videos!) they never mention ORF10. I know, you are always claiming that the function is unknown. But why are you repeatedly mentioning it?
I see strong evidence for the spike as being the monster created by some weird Frankenstein. I understand the role of the ORFs in INFECTION. But where is the proof that ORFs (??????) are lying within the engineered spike? Please, help me in understanding. And - if possible - provide the papers about ORFs you quoted. Thank you, Philip.
I am suffering from long covid(non-vaxxed). I am being treated by The Leading Edge Clinic and tested positive for spike proteins and micro clots. Could the shedding from the vaccinated be the cause of my chronic illnesses?
Sad to here. So you got LC after covid. No, the virus on itsel suffices for this tragedy to happen. I still do not quite get what the people from PME (Pure Media Australia) want to say in detail with their videos. But today I watched the video covering an interview with „their“ chemist (Greg …something), uploaded in December 2024. This is very informativ - and scary….
Maybe reread what I said. I have tremendous respect for Dr Phil’s fine work. But you are right with your point, “He’s an Adult.” Enough said.
She investigated and noised abroad the tight binding of Spike-NTD with the host's fibrinogen. Her conclusion that this is a viral strategy for immune system evasion did not and does not ring true to me. Perhaps immune system evasion as a secondary effect of enhancing Spike-NTD binding in the bioweapon lab for the purpose of initiating / enhancing the multiple clotting pathways, for all manner of clotting - from clotting initiated via spike injury to the lining of the blood vessels to spike bound platelet microclotting to prion initiated cascades to amyloid in clots to "white clots" to perhaps even some day "vaccine" antibody initiated clotting. All pieces of the puzzle of covid and covid vaccine caused clotting that scientists and clinicians from around the world have revealed.
I can now add tight binding of Spike-NTD with the host's fibrinogen into the mix as per below.
https://philipmcmillan.substack.com/p/why-are-embalmers-observations-being?utm_source=podcast-email&publication_id=604377&post_id=146825008&utm_campaign=email-play-on-substack&utm_content=watch_now_button&r=xjgqk&triedRedirect=true&utm_medium=email
Why are Embalmers Observations being Ignored?
Unveiling the Persistent Mystery of Unusual Clots and the Urgent Need for Scientific Inquiry.
Dr Philip McMillan
Jul 20, 2024
Now adding into the previously posted "white clot mix" below this reference which Dr McMillan reported on - Joe Lee JJ - CLIP 01 - Antigen String Theory Dr. Joe Lee interviewed on gigaohmBiological starting at 0:15 into the video if you choose to avoid the "mu sick" here https://x.com/super_spreaders/status/1715220043108069819
Various spike site specific antibodies (up to 17 trillion antibodies in response to a covid "vaccine" - see new comment below) my note: creating harms, each attaching at various antigenic sites on the "vaccine" spike antigen, antibodies and spike antigens linking together with other antibody/antigen complexes creating a latticework of antigen and antibodies initiating clotting / initiating a latticework for clotting to form on or around.
previously posted comment Liked by Dr Philip McMillan new comment below this reposted comment
Report on what Dr. Ryan Cole observed in white clots through his microscope - fibrin, platelets and amyloid and a little bit of how this could come to be. youtube video "Latest Research Findings on Embalmers Strange Clots" by Vejon Health https://www.youtube.com/watch?v=S4Q-vW1tWyo Update from Thomas Haviland MSc at the 53:53 time to 54:42 mark
my note: spike protein has been seen throughout these white clots
my note: prion initiating site "insert" in the spike and interaction between prion initiation and amyloid formation
my note: "CD147, a transmembrane glycoprotein, is expressed on all leukocytes, platelets, and endothelial cells."
my note: spike attaches to CD147 on platelets and can clump platelets together
my note: spike attaching to CD147 on endothelial cells. initiating injury activating a cascade to fibrin
note: wickedpedia - "Fibrinogen is a glycoprotein complex, produced in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood clot. Fibrin clots function primarily to occlude blood vessels to stop bleeding. Fibrin also binds and reduces the activity of thrombin"
note: up to 3 trillion whole spike "vaccine" antigens "created" per injection of mRNA or viral vector "vaccinations". see below
note: Amyloid from spike - 2 of many studies - "Towards the emergence of a new form of the neurodegenerative Creutzfeldt-Jakob disease: Twenty six cases of CJD declared a few days after a COVID-19 vaccine Jab" Also now being reported to be a S2 subunit "feature" in certain Omicron. "SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy"
One of the actions of ivermectin is reported to be binding to CD147 which then prevents spike adhesion to the ivermectin bound CD147. (David E. Scheim, PhD) This is a action of ivermectin which makes the re-profusion drug application of 100 mg dose of ivermectin so effective in the intermediary (before hardening into clots) covid blood "clumping" stage seen here. See Dr. Jackie Stone discuss her own severe covid episode in part 4 of 5 of "The patient experience of ivermectin" (8 minute 22 second video segment)
A 100 mg dose of Ivermectin as Dr. Jackie Stone in Zimbabwe took when, from covid infection from the South African strain, her blood oxygen was declining, her blood "clumping" leading to micro clotting to "clotting out". A life saving 100mg dose which caused temporary visual "wave pool" side effects to which Dr Jackie stone replied "Excellent, I've had enough". Dr. Jackie Stone's account is here https://medicalupdateonline.com/2021/04/the-patient-experience-of-ivermectin/
Thanks to David Scheim, Ph.D. (MIT) and Dr Jackie Stone we know "I" can be used as a covid times re-profusion treatment. A Nov 18, 2020 "Discussion with Dr David Scheim about the effects of Vascular Occlusion during COVID". can be seen here https://www.youtube.com/watch?v=4h2nO4wMRis at the youtube channel HIBBERD HEALTH by Jennifer Hibberd, also one of our covid times heros.This is the most important discussion about the most important anti blood clumping action of and dosing and safety of Ivermectin that I found.
One of the actions of ivermectin is reported to be binding to sialic acid receptors on red blood cells (and CD147 on platelets) which then prevents spike adhesion to the ivermectin bound receptors (David E. Scheim, PhD) This is a action of ivermectin which makes the re-profusion drug application of 100 mg dose of ivermectin so effective in the intermediary (before hardening into clots) covid blood "clumping" stage
New comment - My comments/replies, edited, which were posted to Steve Kirsch's research article on substack "VAERS data shows Moderna causes 30% more deaths per dose than Pfizer"
Thank You for this work. It seemed to me that the pfizer shot had received much more of the reporting undertaken by those revealing The Truth of covid "vaccine" harms than had moderna.
Almost as if moderna had some "special" protection suppressing The Truth of greater moderna harms, as would be expected, with the much higher moderna load of nano-particles with potentially higher levels of harmful spike and harmful antibodies produced
up to 17 trillion antibodies* (my note: causing all manner of harms) produced by the body in response an estimated 10 billion, 40 billion, 50 billion lipid nanoparticles or viral vectors per injection for pfizer, moderna, astrazeneca respectively causing the body to produce up to 3 trillion* whole spike antigens produced per injection *Ogata et al - Marc Girardot is the one who did the gumshoe work parsing these figures out of studies.
from "Karl" Are you sure of those numbers?.... This is an INSANE amount
I got the numbers from replies Marc Girardot sent to my comments and from his substack. As best as I could. So to answer your question "Are you sure of those numbers?" I say this is what I have found so far - actual "for sure" numbers? hard for me to locate with the short search I did. I trust Marc Girardot made a better search, accepting that understandings vary. i.e. from all I have read and heard I understand sars-cov-2 is a "delivery vehicle" for toxic bioweapon spike as are "vaccine" platforms. I understand Marc Girardot questions the "toxic" nature of spike.
I AM SURE that I made the right decision in electing Real Prevention with Real Early Treatment backup instead of an Emergency Use Authorization "vaccine".
His article is titled "What happens to those billions of NanoParticles you've become host to? [Revisited]" here https://covidmythbuster.substack.com/p/what-happens-to-those-billions-of-804 these are quotes from that post - "up to 50 billion viral vectors for AstraZeneca, 40 billion LNPs for Moderna, and likely 10 for Pfizer" and "a study by Harvard Medical: Ogata et al. that detected a maximum level of around 3 trillion spikes at Day 5." and from what source?"17,000 trillion antibodies." (note: new antibody harms "string theory" here https://x.com/super_spreaders/status/1715220043108069819 "string theory") and "Those are numbers way beyond very severe SARS-COV-2 infections: typically at infection peak between 1 and 100 billion virions, are present in the body."
KarlM Alias
Yes, it is strange. It is also strange that so few, on our side, have even mentioned the numbers which I thought would have been a good argument to try and red-pill. ... It would be good for this to get sorted out.
my reply: the thought of billions of my own cells converted to mRNA or viral vector fueled spike factories to then, my own cells, be marked for destruction by my own immune system (thoughts of autoimmune disease) then to be attacked and destroyed by my own immune system .... .
these thoughts and more helped to red-pill me
Yes. "numbers ... .. a good argument to try and red-pill."
Attachments area
Preview YouTube video Latest Research Findings on Embalmers Strange Clots
below is the post that "the below" found "so utterly stupid"
Will R Thomson
Will’s Newsletter
13h
"This article is so utterly stupid. it says "nobody had an answer as to why sarscov2 caused clotting and heart issues". That's classing bullshit gaslighting by another arsehole doctor right there, declaring because she is stupid, everyone else is stupid."
Another piece of the big picture - "Spike-NTD binds with the host fibrinogen"
natural? or bioweapon engineering to induce sars-cov2 fast and slow kill clotting features?
A hidden strategy: How SARS-CoV-2 uses fibrinogen to evade the immune system
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https://medicalxpress.com/news/2025-03-hidden-strategy-sars-cov-fibrinogen.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter
March 31, 2025 dialog
The GIST
Editors' notes
A hidden strategy: How SARS-CoV-2 uses fibrinogen to evade the immune system
by Parth Sarthi Sen Gupta
This cover art depicts SARS-CoV-2's novel immune escape strategy, where Spike-NTD binds with the host fibrinogen, shielding the virus from NTD-directed antibodies and facilitating immune evasion. Credit: Parth Sarthi Sen Gupta
As scientists, we often think we understand a virus—its structure, its tricks, the way it moves through the body. But every once in a while, we stumble upon something unexpected—something that completely changes the way we see an infection.
I have spent years studying the molecular tactics of viruses—how they invade, replicate, and most intriguingly, how they evade our immune system. Some strategies are well documented: antigenic drift, glycan shielding, immune suppression. But every so often, we stumble upon a novel mechanism that redefines our understanding of viral pathogenesis.
A recent finding in Nature showed that the spike protein of SARS-CoV-2 binds with fibrinogen, leading to thrombo-inflammation. This raises a fundamental question: Why does the virus need to bind with fibrinogen? Could this interaction provide an evolutionary advantage to the virus? Could this be the reason behind post-COVID heart attack cases?
In our recent study, published in ACS Pharmacology & Translational Science, we found that SARS-CoV-2, the virus that causes COVID-19, has a sneaky way of escaping immune detection. It binds to fibrinogen, a key protein involved in blood clotting with stronger affinity than antibodies. This interaction not only helps the virus evade immune cells but may also contribute to the dangerous clotting issues seen in severe COVID-19 cases. This finding could change how we think about the virus and how we treat it.
The mystery of COVID-19, blood clots and immune escape
When COVID-19 first emerged, most people focused on its impact on the lungs. But soon, doctors started reporting something unusual—many critically ill patients were developing blood clots, leading to strokes, heart attacks and organ failure. This was strange because viral infections don't typically cause widespread clotting issues.
For months, researchers tried to understand why. Some thought it was due to excessive inflammation, while others suspected direct viral damage to blood vessels. But no one had a clear answer.
That's when we decided to look at fibrinogen, one of the most important proteins involved in blood clotting. Our study revealed that the γ-chain demonstrates a higher binding affinity for the NTD domain compared to the neutralizing antibodies, providing striking insights and suggesting that the virus had evolved a mechanism to preferentially bind to fibrinogen rather than the neutralizing antibodies.
Fibrinogen acts like glue, helping platelets stick together to form clots when needed. But what if SARS-CoV-2 had found a way to exploit this system? We proposed the Dual Immune Evasion Strategy of the virus:
Mutating the receptor binding domain (RBD) of the spike protein: The virus introduces mutations in the RBD region of the spike protein to escape neutralizing antibodies targeted against it.
Fibrinogen binding to N-terminal domain (NTD) of spike: To protect the more conserved NTD, the virus interacts with fibrinogen, protecting the NTD region from antibody recognition.
This dual strategy of SARS-CoV-2 helps it to maintain infectivity while escaping the host immunity.
A) 3D conformation of the spike NTD bound to the γ-chain of fibrinogen (docked conformation), along with S2M28 (PDB ID: 7LY0) and SARS2-57 (PDB ID: 7SWW). B) Surface diagram showing the binding of spike NTD to the γ-chain of fibrinogen, S2M28, and SARS2-57, highlighting the similar interacting orientations of the three. C) MMGBSA binding free energy comparison for the γ-chain of fibrinogen and neutralizing antibodies (S2M28, SARS2-57, and 4A8). Credit: ACS Pharmacology & Translational Science (2025). DOI: 10.1021/acsptsci.5c00122
Implications for immune evasion and pathogenesis
Viruses are masterful at exploiting host systems. HIV hides within host cells; influenza frequently mutates its surface proteins; and now, we see that SARS-CoV-2 might be leveraging fibrinogen as a molecular cloak.
Fibrinogen is known to interact with immune cells, particularly neutrophils and macrophages, through integrin receptors. By binding fibrinogen, the spike protein might be interfering with normal immune signaling, preventing efficient recognition and clearance of the virus. This could contribute to prolonged viral persistence in some patients, leading to chronic or severe disease.
Additionally, this interaction might explain why some COVID-19 patients develop severe inflammatory and coagulation-related complications. If spike-fibrinogen binding alters clotting dynamics, it could be a driving factor behind the thrombotic events seen in critical cases. Understanding this mechanism gives us a new target for potential therapeutic interventions.
Looking forward: What this means for treatment and prevention
Our finding raises important questions: Can we block the spike-fibrinogen interaction to reduce disease severity? Could fibrinogen levels serve as a biomarker for predicting COVID-19 complications? And, most critically, does this mechanism play a role in other emerging variants?
One possible therapeutic avenue is developing small molecules or monoclonal antibodies that disrupt spike-fibrinogen binding. By preventing this interaction, we might be able to restore normal immune function and reduce clotting risks in severe patients.
Additionally, our findings emphasize the need to look beyond traditional receptor interactions when studying viral immune evasion. If SARS-CoV-2 can manipulate host proteins like fibrinogen, what other molecular partnerships remain undiscovered? This study serves as a stepping stone for deeper investigations into the interplay between viral proteins and host immune factors.
A personal perspective
Scientific discovery is often a mix of persistence and serendipity. When we began this study, we weren't looking for an immune evasion mechanism—we were searching for the reason behind the fibrinogen binding. But as the data unfolded, it became clear that we had uncovered something bigger.
As a computational biologist, I have always been fascinated by the unseen molecular dialogues between viruses and host cells. The fact that a virus can exploit a key clotting protein to evade immune detection is both astonishing and humbling. It's a reminder that, despite our scientific advancements, nature still holds secrets waiting to be unraveled.
Conclusion
Our study on the spike-fibrinogen interaction reveals a novel immune escape strategy of SARS-CoV-2, with potential implications for disease severity and treatment. By binding fibrinogen, the virus not only disrupts normal clotting but may also evade immune surveillance, contributing to prolonged infection and severe inflammatory responses.
Understanding these molecular interactions is crucial for developing targeted therapies. As we continue to study the intricate battle between SARS-CoV-2 and the immune system, one thing is clear: The virus is a formidable opponent, but with deeper insight, we can develop strategies to counter its tricks.
Science, at its core, is about uncovering the unknown. This discovery is just one piece of the puzzle, but it brings us closer to understanding—and ultimately defeating—the virus that has reshaped our world.
This story is part of Science X Dialog, where researchers can report findings from their published research articles. Visit this page for information about Science X Dialog and how to participate.
More information: Saroj Kumar Panda et al, Spike Protein–Fibrinogen Interaction: A Novel Immune Evasion Strategy of SARS-CoV-2?, ACS Pharmacology & Translational Science (2025). DOI: 10.1021/acsptsci.5c00122
Dr. Parth Sarthi Sen Gupta is an associate professor in the School of Biosciences and Bioengineering, D Y Patil International University. He has published more than 50 research articles and book chapters in reputed peer reviewed journals. He is a computational biologist working on designing and developing therapeutics against various diseases. His research work on COVID-19 has been highlighted by various national and international news agencies and recognized by world health organizations.
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Don’t WE already know this shit a long long time ago? Or is this for the normies…
Don't threaten me, girlie.