This was a sin of omission to not complete the research question about the optimal dose of steroid to use in severe COVID-19. RECOVERY Trial was the most important breakthrough in therapy using Dexamethasone for COVID-19, occurring in June 2020. Link to publication in “The Conversation” >
That was an excellent video. Dexamethasone is just one drug of many that have been successfully used to treat COVID patients, but are anywhere from ignored to actively repressed by publicly health authorities. There is one answer as you showed on your video. $$$$$$$$$$$$$$$$$$$$$$$$. Only expensive patented drugs are to be strongly recommended for COVID. These expensive drugs under patent are only authorized under an EUA if no approved drugs are available and effective. Cheap effective repurposed drugs are a major threat to the expensive, but highly profitable drugs. They must be suppressed. The objective during the pandemic is too prolong the COVID pandemic as long as possible and to make the greatest amount of profit possible. How many lives has this cost us? Millions. Our public health officials are murderous criminals. That is the grim reality, unfortunately.
Excellent questioning Philip ! How can it be that 10s of thousands if not 100s of thousand physicians/MDs did not read, study or at best conclude like Dr. Chetty ??? How can it be that NONE of the Western Medical Faculties pick that up and conclude ?! Even I as non-MD but Chemist & Engineer would have picked this study up and just saved patients lifes ! I mean after seeing 1.000s of people dyeing a suffocating death what can you do wrong with a steroid that can be given even in grams quantity ? Why never anybody picked up IVM one of the safest drugs applied over a Billion times ?! I suspect that WHATEVER drug works and saves lifes before the vaccine comes out and thereafter to maintain high mRNA sales was not allow to work ! Not allowed to exist in a treatment protocoll. Fluoxetine/Fuvoxamine, Ivermectin, Dexamethason/Prednisolon, Antihistamins are the most famous examples of surpressed pharmaceuticals which saved thousands of lives and could have saved MILLIONS of lives IF applied on time. And this "medicine" called "on-time" was also surpresssed - almost intentionally !! Sorry to be so "direct" - the formula "on time + steroid + antihist." was deliberately surpressed because it worked at Dr. Chetties environment, in India etc. But western MDs were under a tremendous dictate comparable to health-fashism. And that is no conspiracy - that is fact. Many MDs suffered terribly, closing down their consultories, paid heavy fines if they did what Dr. Chetty did. That was plain terror supported and fosteres by the Medical Professors, Primars and medical authorities. This dear Philip is a dark spot in the History of Medicine - a very dark one.
Dr McK Jefferies discussed In his book, originally published in 1981 by Chas C. Thomas (2nd edition titled, Safe Uses of Cortisol, 1996), he describes the use of physiological doses of cortisol, hydrocortisone. This would be 5 to 10 mg doses that would not suppress the adrenal gland but would reduce adrenal stress and allow repletion of function.
Sun et al have reported for ARDS where MIF overexpression has been implicated in the cytokine storm of ARDS [1-5], the use of low-dose but not high-dose corticosteroids significantly reduced the mortality rate of patients with ARDS (OR: 0.43, 95% CI 0.24-0.79, p=0.0006), and where earlier administration upon onset of ARDS was better [6].
While the glucocorticoid receptor NR3C1 was reported to be upregulated in PBMCs from mild patients it was notably downregulated in patients with severe COVID-19 [7]. The latter was associated with CXCL8 overexpression and the accumulation of dysfunctional neutrophils which were non-responsive to type I interferons [7]. Interestingly, HERV-K102 RNA expression in PBMCs is increased in healthy nonagenarians over healthy younger adults and associates with enhanced CXCL8 and neutrophil activation [8] implying there may be a connection of NR3C1 with HERV-K102 and CXCL8 co-expression. Along these lines, Ren et al reported that in BALF, NR3C1 is detected only in macrophages not infected with SARS-COV-2, whereas CXCL8 is detected in the macrophages in BALF that are infected with SARS-CoV-2 [9]. Taken together these results might suggest the involvement of a disrupted or deregulated NR3C1/MIF/HIF1A/HERV-K102 axis in SARS-CoV-2 infected macrophages associated with COVID-19 progression which may involve cytokine upregulation by MIF/HIF1A. Of course the infection of macrophages pertains to ADE albeit a novel type that does not select for variants.
1. Husebø GR, Bakke PS, Grønseth R, Hardie JA, Ueland T, Aukrust P, et al. Macrophage migration inhibitory factor, a role in COPD. Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L1-7. doi: 10.1152/ajplung.00461.2015.
2. Das R, Koo MS, Kim BH, Jacob ST, Subbian S, Yao J, Leng L, et al. Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E2997-3006. doi: 10.1073/pnas.1301128110.
3. Roger T, Schneider A, Weier M, Sweep FC, Le Roy D, Bernhagen J, et al. High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E997-1005. doi: 10.1073/pnas.1514018113.
4. Flaster H, Bernhagen J, Calandra T, Bucala R. The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity. Mol Endocrinol. 2007 Jun;21(6):1267-80. doi: 10.1210/me.2007-0065.
5. Calandra T, Bucala R. Macrophage migration inhibitory factor (MIF): a glucocorticoid counter-regulator within the immune system. Crit Rev Immunol. 2017;37(2-6):359-370. doi: 10.1615/CritRevImmunol.v37.i2-6.90.
6. Sun S, Liu D, Zhang H, Zhang X, Wan B. Effect of different doses and time-courses of corticosteroid treatment in patients with acute respiratory distress syndrome: A meta-analysis. Exp Ther Med. 2019 Dec;18(6):4637-4644. doi: 10.3892/etm.2019.8167.
7. Park JH, Lee HK. Re-analysis of single cell transcriptome reveals that the NR3C1-CXCL8-neutrophil axis determines the severity of COVID-19. Front Immunol. 2020 Aug 28;11:2145. doi: 10.3389/fimmu.2020.02145.
8. Autio A, Nevalainen T, Mishra BH, Jylhä M, Flinck H, Hurme M. Effect of aging on the transcriptomic changes associated with the expression of the HERV-K (HML-2) provirus at 1q22. Immun Ageing. 2020 May 13;17:11. doi: 10.1186/s12979-020-00182-0.
9. Ren X, Wen W, Fan X, Hou W, Su B, Cai P, et al. COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell. 2021 Apr 1;184(7):1895-1913.e19. doi: 10.1016/j.cell.2021.01.053.
I miss you on Li but I hesitate to comment because I have a family member, a retired so called medical professional, that is like a bot and may have been reacting unfavorably to my likes which she saw.
Thank you Dr McMillan. I am wondering how does this compare to using Methylprednisolone or Prednisone. Dr Chetty seems to prefer the latter, and I adopted this in my practice. Not sure if there are other studies on Methylprednisolone or Prednisone in covid? Also these should be started in the 2nd phase of covid right? Not in the early viral phase.
The fix was in from before "covid". Nothing was going to stop the Mrna "vaccine" program. FEAR MUST BE MAINTAINED! Effective treatment for covid must be suppressed and not be "officially" acknowledged.
The beginning of the implementation of "their" plan to KILL HCQ AND STEROIDS etc, to kill early covid treatment and effective emergency room and hospital covid treatment, to push remdesivir and the vaccine only path is documented here https://apps.who.int/iris/bitstream/handle/10665/330680/WHO-HEO-RDBlueprint%28nCoV%29-2020.1-eng.pdf?sequence=1 WHO R&D Blueprint Informal consultation on prioritization of candidate therapeutic agents for use in novel coronavirus 2019 infection Geneva, Switzerland, 24 January 2020 - Coronavirus Outline of designs for experimental vaccines and therapeutics Draft version Jan 27, 2020
They "KILLED" steroids while the document acknowledges "although there is evidence of efficacy in the setting of severe illness".
The US representative at this Jan 2020 meeting was fauci stand in Hilary Marston - Medical Officer and Policy Advisor National Institute of Allergy and Infectious Diseases" with a big pharma "fixer" "McKinsey & Company and .. Bill & Melinda Gates Foundation" employment background.
Day 8 - Treatment Protocoll by Dr. Shankara Chetty (high dose Prednisolone, Antihistamines & some some complementing cheap standard pharmaka) would have saved 90, 95 % of lives ? Not only the "authorities" denied this protocoll - they missed the "ON-TIME" moment, when to start treatment. Most were sent home into quarantene with a leaflet with a hotline-telefone number, which in many cases was engaged, did not work . . . . and lead to a treatment delay of 24, 36, 48, 72 hours which is far, far too late when the "shit hits the fan" or an allergic person to a bee-sting is hyperventilating trying to catch air. The ignored - the INTENTIONALLY ignored hypersensitivity was the cause of most of the death this pandemic has caused. But what is a human live worth ? Today at this very moment, every day 500+ Ukrainian soldiers are sacrified, slaughtered on the battle field - not counting the lifes on Russian side. And nobody wants to end this. Slowly I am losing faith in the seemingly fact that we left medivial age behind us - right ? But maybe some "Seniors" will start thinking the same when all the facts (also fo this useless war - based on the same motivation & devilish ethics as with the pandemic) form a TSUNAMI of vomiting consciousness. I may see some of it in the UN . . . . . but it maybe only a spark of hope - not more.
dendrimer–N-acetylcysteine conjugate that specifically targets activated macrophages, improves outcomes in preclinical models of systemic inflammation and neuroinflammation. I
dendrimer–N-acetylcysteine conjugate that specifically targets activated macrophages, improves outcomes in preclinical models of systemic inflammation and neuroinflammation.
That was an excellent video. Dexamethasone is just one drug of many that have been successfully used to treat COVID patients, but are anywhere from ignored to actively repressed by publicly health authorities. There is one answer as you showed on your video. $$$$$$$$$$$$$$$$$$$$$$$$. Only expensive patented drugs are to be strongly recommended for COVID. These expensive drugs under patent are only authorized under an EUA if no approved drugs are available and effective. Cheap effective repurposed drugs are a major threat to the expensive, but highly profitable drugs. They must be suppressed. The objective during the pandemic is too prolong the COVID pandemic as long as possible and to make the greatest amount of profit possible. How many lives has this cost us? Millions. Our public health officials are murderous criminals. That is the grim reality, unfortunately.
Excellent questioning Philip ! How can it be that 10s of thousands if not 100s of thousand physicians/MDs did not read, study or at best conclude like Dr. Chetty ??? How can it be that NONE of the Western Medical Faculties pick that up and conclude ?! Even I as non-MD but Chemist & Engineer would have picked this study up and just saved patients lifes ! I mean after seeing 1.000s of people dyeing a suffocating death what can you do wrong with a steroid that can be given even in grams quantity ? Why never anybody picked up IVM one of the safest drugs applied over a Billion times ?! I suspect that WHATEVER drug works and saves lifes before the vaccine comes out and thereafter to maintain high mRNA sales was not allow to work ! Not allowed to exist in a treatment protocoll. Fluoxetine/Fuvoxamine, Ivermectin, Dexamethason/Prednisolon, Antihistamins are the most famous examples of surpressed pharmaceuticals which saved thousands of lives and could have saved MILLIONS of lives IF applied on time. And this "medicine" called "on-time" was also surpresssed - almost intentionally !! Sorry to be so "direct" - the formula "on time + steroid + antihist." was deliberately surpressed because it worked at Dr. Chetties environment, in India etc. But western MDs were under a tremendous dictate comparable to health-fashism. And that is no conspiracy - that is fact. Many MDs suffered terribly, closing down their consultories, paid heavy fines if they did what Dr. Chetty did. That was plain terror supported and fosteres by the Medical Professors, Primars and medical authorities. This dear Philip is a dark spot in the History of Medicine - a very dark one.
Dr McK Jefferies discussed In his book, originally published in 1981 by Chas C. Thomas (2nd edition titled, Safe Uses of Cortisol, 1996), he describes the use of physiological doses of cortisol, hydrocortisone. This would be 5 to 10 mg doses that would not suppress the adrenal gland but would reduce adrenal stress and allow repletion of function.
Thanks Dr McMillan much appreciated
Conspiracy? Explanation? MegaPharmas & Bi££ion$.
Their gross & obscene profiteering, silenced any genuine medical "cheap" progress.
Thank you Dr. McMillan for the video!
Sun et al have reported for ARDS where MIF overexpression has been implicated in the cytokine storm of ARDS [1-5], the use of low-dose but not high-dose corticosteroids significantly reduced the mortality rate of patients with ARDS (OR: 0.43, 95% CI 0.24-0.79, p=0.0006), and where earlier administration upon onset of ARDS was better [6].
While the glucocorticoid receptor NR3C1 was reported to be upregulated in PBMCs from mild patients it was notably downregulated in patients with severe COVID-19 [7]. The latter was associated with CXCL8 overexpression and the accumulation of dysfunctional neutrophils which were non-responsive to type I interferons [7]. Interestingly, HERV-K102 RNA expression in PBMCs is increased in healthy nonagenarians over healthy younger adults and associates with enhanced CXCL8 and neutrophil activation [8] implying there may be a connection of NR3C1 with HERV-K102 and CXCL8 co-expression. Along these lines, Ren et al reported that in BALF, NR3C1 is detected only in macrophages not infected with SARS-COV-2, whereas CXCL8 is detected in the macrophages in BALF that are infected with SARS-CoV-2 [9]. Taken together these results might suggest the involvement of a disrupted or deregulated NR3C1/MIF/HIF1A/HERV-K102 axis in SARS-CoV-2 infected macrophages associated with COVID-19 progression which may involve cytokine upregulation by MIF/HIF1A. Of course the infection of macrophages pertains to ADE albeit a novel type that does not select for variants.
1. Husebø GR, Bakke PS, Grønseth R, Hardie JA, Ueland T, Aukrust P, et al. Macrophage migration inhibitory factor, a role in COPD. Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L1-7. doi: 10.1152/ajplung.00461.2015.
2. Das R, Koo MS, Kim BH, Jacob ST, Subbian S, Yao J, Leng L, et al. Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E2997-3006. doi: 10.1073/pnas.1301128110.
3. Roger T, Schneider A, Weier M, Sweep FC, Le Roy D, Bernhagen J, et al. High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E997-1005. doi: 10.1073/pnas.1514018113.
4. Flaster H, Bernhagen J, Calandra T, Bucala R. The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity. Mol Endocrinol. 2007 Jun;21(6):1267-80. doi: 10.1210/me.2007-0065.
5. Calandra T, Bucala R. Macrophage migration inhibitory factor (MIF): a glucocorticoid counter-regulator within the immune system. Crit Rev Immunol. 2017;37(2-6):359-370. doi: 10.1615/CritRevImmunol.v37.i2-6.90.
6. Sun S, Liu D, Zhang H, Zhang X, Wan B. Effect of different doses and time-courses of corticosteroid treatment in patients with acute respiratory distress syndrome: A meta-analysis. Exp Ther Med. 2019 Dec;18(6):4637-4644. doi: 10.3892/etm.2019.8167.
7. Park JH, Lee HK. Re-analysis of single cell transcriptome reveals that the NR3C1-CXCL8-neutrophil axis determines the severity of COVID-19. Front Immunol. 2020 Aug 28;11:2145. doi: 10.3389/fimmu.2020.02145.
8. Autio A, Nevalainen T, Mishra BH, Jylhä M, Flinck H, Hurme M. Effect of aging on the transcriptomic changes associated with the expression of the HERV-K (HML-2) provirus at 1q22. Immun Ageing. 2020 May 13;17:11. doi: 10.1186/s12979-020-00182-0.
9. Ren X, Wen W, Fan X, Hou W, Su B, Cai P, et al. COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell. 2021 Apr 1;184(7):1895-1913.e19. doi: 10.1016/j.cell.2021.01.053.
I miss you on Li but I hesitate to comment because I have a family member, a retired so called medical professional, that is like a bot and may have been reacting unfavorably to my likes which she saw.
Thank you Dr McMillan. I am wondering how does this compare to using Methylprednisolone or Prednisone. Dr Chetty seems to prefer the latter, and I adopted this in my practice. Not sure if there are other studies on Methylprednisolone or Prednisone in covid? Also these should be started in the 2nd phase of covid right? Not in the early viral phase.
What happened to this study started in April 2020 due to complete by June 2021? Inhaled Corticosteroid Treatment of COVID19 Patients With Pneumonia https://clinicaltrials.gov/ct2/show/record/NCT04355637
And this study started in July 2020 due to complete by Jnauary 2021? STerOids in COVID-19 Study (STOIC) https://clinicaltrials.gov/ct2/show/NCT04416399
The fix was in from before "covid". Nothing was going to stop the Mrna "vaccine" program. FEAR MUST BE MAINTAINED! Effective treatment for covid must be suppressed and not be "officially" acknowledged.
The beginning of the implementation of "their" plan to KILL HCQ AND STEROIDS etc, to kill early covid treatment and effective emergency room and hospital covid treatment, to push remdesivir and the vaccine only path is documented here https://apps.who.int/iris/bitstream/handle/10665/330680/WHO-HEO-RDBlueprint%28nCoV%29-2020.1-eng.pdf?sequence=1 WHO R&D Blueprint Informal consultation on prioritization of candidate therapeutic agents for use in novel coronavirus 2019 infection Geneva, Switzerland, 24 January 2020 - Coronavirus Outline of designs for experimental vaccines and therapeutics Draft version Jan 27, 2020
They "KILLED" steroids while the document acknowledges "although there is evidence of efficacy in the setting of severe illness".
The US representative at this Jan 2020 meeting was fauci stand in Hilary Marston - Medical Officer and Policy Advisor National Institute of Allergy and Infectious Diseases" with a big pharma "fixer" "McKinsey & Company and .. Bill & Melinda Gates Foundation" employment background.
Because it was never about health, in fact it was exactly opposite to healing people.
It is far more sinister than just $$$
Day 8 - Treatment Protocoll by Dr. Shankara Chetty (high dose Prednisolone, Antihistamines & some some complementing cheap standard pharmaka) would have saved 90, 95 % of lives ? Not only the "authorities" denied this protocoll - they missed the "ON-TIME" moment, when to start treatment. Most were sent home into quarantene with a leaflet with a hotline-telefone number, which in many cases was engaged, did not work . . . . and lead to a treatment delay of 24, 36, 48, 72 hours which is far, far too late when the "shit hits the fan" or an allergic person to a bee-sting is hyperventilating trying to catch air. The ignored - the INTENTIONALLY ignored hypersensitivity was the cause of most of the death this pandemic has caused. But what is a human live worth ? Today at this very moment, every day 500+ Ukrainian soldiers are sacrified, slaughtered on the battle field - not counting the lifes on Russian side. And nobody wants to end this. Slowly I am losing faith in the seemingly fact that we left medivial age behind us - right ? But maybe some "Seniors" will start thinking the same when all the facts (also fo this useless war - based on the same motivation & devilish ethics as with the pandemic) form a TSUNAMI of vomiting consciousness. I may see some of it in the UN . . . . . but it maybe only a spark of hope - not more.
https://www.science.org/doi/10.1126/scitranslmed.abo2652
nanotherapy for severe COVID-19 attenuates inflammation and neurological injury markers and improves outcomes in a phase2a clinical trial
dendrimer–N-acetylcysteine conjugate that specifically targets activated macrophages, improves outcomes in preclinical models of systemic inflammation and neuroinflammation. I
https://www.science.org/doi/10.1126/scitranslmed.abo2652
dendrimer–N-acetylcysteine conjugate that specifically targets activated macrophages, improves outcomes in preclinical models of systemic inflammation and neuroinflammation.