If you understand this concept, everything else is easy to grasp about the COVID-19 pandemic. There are many viruses around us all the time. The upper airway has a sophisticated immune system to manage any viral or bacterial infection. Iwasaki A, Foxman EF, Molony RD. Early local immune defences in the respiratory tract. Nat Rev Immunol. 2017 Jan;17(1):7-20
It seems quite simple and logical that it may very well be an evolutionary adaptation to avoid making long-lasting adaptive memory to the spike proteins of a coronavirus due to their propensity to mutate frequently. By relying on innate/generalized/mucosal immune responses (nk cells, non-specific circulating antibodies , memory tcells etc.) to functionally-constrained proteins, the body can generally ward off serious infection (from variants within the viral swarm ) albeit at the cost of not always being entirely successful at stopping it altogether (for instance when viral load is high or the when weakened due to stress, poor diet etc..). It's a trade off - better broader long, lasting protection but less specific protection. In this particular case, from what I have read, the SARS Cov-2 virus family appears to have a greater propensity to elicit a specific antigen antibody response due to the particularly toxic nature of the spike's interaction with the body. This sets up a catch-22: a broad innate response would be preferable but might be outgunned so to speak but an long-lasting adaptive would set one up for imprinting issues (though less likely in the natural infection vs transfection).
It's a difficult situation in light of the potential seriousness of infection (in some but not all) but the idea that the best solution is to force to the body (via inoculation) to manufacture a toxic protein (with unknown locations and quantity) AND potentially cement a spike-antibody response against this highly mutable virus is absolutely asinine.
Greater support of the innate immune system and early therapeutics were/are the most rational, scientific approach to combating this problem as antibodies are not a correlate of protection. One doesn't have to be a scientist to see the obvious 'flaws' in the pandemic response. It's hard for me to attribute this to simple incompetence but maybe that's just me.
I do see the value of nasal/oral disinfecting rinses to reduce viral load and let our innate/mucosal immune system get a handle on things.
However, i think the implication that the viruses do not get past the mucosal immune system or that we do not need the adaptive immune system is incorrect. We swallow viruses all the time and some of them (out of billions) do get past the mucosal immune system through various means. Those that go down the gullet can be detected by the Peyer's Patches which start the process of tuning the adaptive immune system to the virus (without any injection needed!). See this talk with Prof.Robert Clancy about immunology, microbiomes, general vs specifc interventions. https://www.youtube.com/watch?v=q8jVEpB1ieE In particular, he explains why repeated shots might actually downregulate the body's response to the virus, like desensitization therapy for allergens.
It seems quite simple and logical that it may very well be an evolutionary adaptation to avoid making long-lasting adaptive memory to the spike proteins of a coronavirus due to their propensity to mutate frequently. By relying on innate/generalized/mucosal immune responses (nk cells, non-specific circulating antibodies , memory tcells etc.) to functionally-constrained proteins, the body can generally ward off serious infection (from variants within the viral swarm ) albeit at the cost of not always being entirely successful at stopping it altogether (for instance when viral load is high or the when weakened due to stress, poor diet etc..). It's a trade off - better broader long, lasting protection but less specific protection. In this particular case, from what I have read, the SARS Cov-2 virus family appears to have a greater propensity to elicit a specific antigen antibody response due to the particularly toxic nature of the spike's interaction with the body. This sets up a catch-22: a broad innate response would be preferable but might be outgunned so to speak but an long-lasting adaptive would set one up for imprinting issues (though less likely in the natural infection vs transfection).
It's a difficult situation in light of the potential seriousness of infection (in some but not all) but the idea that the best solution is to force to the body (via inoculation) to manufacture a toxic protein (with unknown locations and quantity) AND potentially cement a spike-antibody response against this highly mutable virus is absolutely asinine.
Greater support of the innate immune system and early therapeutics were/are the most rational, scientific approach to combating this problem as antibodies are not a correlate of protection. One doesn't have to be a scientist to see the obvious 'flaws' in the pandemic response. It's hard for me to attribute this to simple incompetence but maybe that's just me.
Given all this, what mouthwash or nasal rinse protocol could one use to assist mucosal immunity in this area -- if any?
Yes! Yes! Yes! It’s all in the noses ( & throats ) hiding right underneath our noses ( & eyes )
I do see the value of nasal/oral disinfecting rinses to reduce viral load and let our innate/mucosal immune system get a handle on things.
However, i think the implication that the viruses do not get past the mucosal immune system or that we do not need the adaptive immune system is incorrect. We swallow viruses all the time and some of them (out of billions) do get past the mucosal immune system through various means. Those that go down the gullet can be detected by the Peyer's Patches which start the process of tuning the adaptive immune system to the virus (without any injection needed!). See this talk with Prof.Robert Clancy about immunology, microbiomes, general vs specifc interventions. https://www.youtube.com/watch?v=q8jVEpB1ieE In particular, he explains why repeated shots might actually downregulate the body's response to the virus, like desensitization therapy for allergens.