I very recently read an article in NYT or WP ( can’t recollect) which was full of anecdotes about adverse effects of ivermectin, including deaths. There was no background information as to why the deaths could be due to ivermectin. Such negative reporting. Millions around the world survived covid, often without a flutter, thanks to ivermectin. I don’t know why international papers like these don’t follow international experience and report them. A successful medical practice is a world good, no matter where it came from them. The medical community anywhere cannot ignore them. At best seek more clarifications. The few adverse events could be due to self medicated overdose. I note (first time) that last week, there was this international Ivermectin day. How could a celebrated medicine like it could go wrong ? If the clinicians didn’t care to understand how exactly it could be safely and successfully used, the drug is not to be blamed. And this happens only in the western system of medicinal practice.
Is that in line with the so far knowledge that IVM is a 3CL Protease Inhibitor ? See Dr. Campbell youtube where he explains comparison study of IVM vs. Paxlovid. Both work as P.Inhib.
I consider IVM as antiviral and - remember e.g. Papa Newguinea case where society was largely given (also) IVM doses. Then there is India were reports showed that IVM works well, small scale studies from IL etc... would you exclude IVM in your statement "No antiviral has shown great value here" ?
I am surprised about this mechanism of IVM. My knowledge was (source: e.g. Dr. Campbell, youtube - that IVM works as a 3CL-Protease Inhibitor, i.e. IVM is inhibiting the replication of SARS CoV2. In a video he explains a study where IVM was tested against PAvloxid - both work sam
- “CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis” - https://www.nature.com/articles/s41392-022-01230-5 "CD147 has been identified as a universal receptor for SARS-CoV-2 and its variants, which could initiate COVID-19-related cytokine storm."
- The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article
my note: evildoers who have taken over "Nature" can be relied upon, these days, to serve evil (The Editor-in-Chief therefore no longer has confidence in the reliability of this review article. None of the authors agree to this retraction. The online version of this article contains the full text of the retracted article as Supplementary Information.) here
Dr. Jackie Stone " So – if covid is a thrombotic event, ivermectin is a reperfusion drug.”
In addition to these effects, “The brain fog lifts, the feeling of impending doom lifts, the body pain, the systemic symptoms all start to go away, the headache goes away” she adds. The roof ( ceiling of clinic treatment room?) looked as if it was a wave pool but she told herself it was a visual side effect of ivermectin and thought, “Excellent! I’ve had enough [ivermectin]!”
We’ve treated hundreds of covid patients since the beginning of the pandemic. Ivermectin, HCQ and TMPRSS blocking agents. We’ve known for a long time now that it workers. Prohibition of these drugs was a crime against humanity. This evil must go away.
Vitamin D3 is far cheaper and less controversial than any other intervention - people need to get out in the sun and fresh air for covid and many other health reasons. The lockdowns could be considered a criminally negligent intervention when they prevented people going outside in the summer.
Doctors in many (lesser ?) parts of the world began rallying successfully against covid in 2021 during the delta wave applying better clinical understanding of the disease including early treatments. Ivermectin was one of their key weapons. In 2020 and in early 2021, the entire world followed western guidelines, no treatments in viral phase, with many people heading to hospitals with chocked lungs. Some doctors here and there saw it as inflammation, used arthritis drugs like Anakinra with some success. Chocked lungs was the cause for excessive deaths in that phase. It is unfortunate that not many doctors around the world could recall that in another condition of filariasis, chocked lungs were cleared with safe use of Ivermectin. This was one of its established use in some parts of the world. One must examine why sharp clinical thinking froze in that period everywhere. There were some successful patient level trials with Ivermectin as one of the drugs and there was some kind of field use too. But not until about mid 2021, did Ivermectin become a key medicine to contain this disease in large scale. When covid 19 is taught in medical schools in future generations, Ivermectin must be a key point.
Anti histamines are the most effective against the Omicrons, even where Ivermectin wouldn’t be fully adequate. Their primary mechanism here could be that of lysosomotropic, their chemical change in the lysosomes. Being Cationic Amphiphilic Drugs ( CADs), by virtue of their chemical structures, they pick up the protons (acidity) in the lysosomes to become cationic and deny any kind of RNA activity for the virus inside the cell. In fact, my guess is that these drugs, not just anti histamines but hundreds of drugs from many other indications sharing that nitrogen structure feature, will neutralise the active cationic segments of the virus spike protein outside the cell itself denying the route for its cell entry. The result, no viral build up, not enough viral load in those treated individuals for transmission in the neighbourhood and eventually no spread of the virus in society. Precisely the story in societies that switched full force to early treatments with these common drugs. In those treatments, Ivermectin is a handy help, as it provides additional mechanisms for anti viral work.
Ivermectin has off label anti viral and anti inflammatory properties. However, in the doses acceptable to humans ( as anti parasitic), these properties are only part effective. It can be made up with other groups like anti histamines. So, Ivermectin is best used as part of multi drug prescription. This is fine because viral respiratory infections are also traditionally treated with multiple products. So, Ivermectin has a role in covid management. The background needs to be well understood while being prescribed. Dr. Chetty used to mention how Ivermectin can be profitably used in the autoimmune phase of covid (with variants prior to Omicron, upto delta) to clear congested lungs of dead cellular matter, very similar to its established use in filarial pneumonia. He also mentioned about DCC ( Diethyl carbamazine citrate) being a better drug for that role. It would be nice if he can post his exact views on this subject in the comments box of this podcast. I haven’t heard any other physician talking about such a need.
Some real life feedback, non-scientific - a friend of mine reached out to me to get IVM for one of his buddies. The person (had covid post vaccination) in question had lost smell and taste for several months. The gentlemen consulted with various Dr, acupuncture and more. No luck. Surgery was proposed! After taking IVM for 5 days he stayed - smell and taste 80% back…
Omicrons’ less capability to cell entry and their ready susceptibility to anti histamines could be sides of the same coin. I don’t know if there is any reported research comparing the chemical structural features of the spike proteins of some of the Omicrons with the older variants like Wuhan, Alpha and Delta. I suspect Omicrons will have less number of active cationic spike segments than the predecessors. It means less propensity to lodge on the negative surfaced cell walls in preparation for cell entry. It also means easier work for anti histamines or similarly structured other anti virals. The earlier variants could have had more locking sites on the cell wall. It is like your shirt having only one button instead of the normal 5 buttons.
- “CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis” - https://www.nature.com/articles/s41392-022-01230-5 "CD147 has been identified as a universal receptor for SARS-CoV-2 and its variants, which could initiate COVID-19-related cytokine storm."
- The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article
my note: evildoers who have taken over "Nature" can be relied upon, these days, to serve evil (The Editor-in-Chief therefore no longer has confidence in the reliability of this review article. None of the authors agree to this retraction. The online version of this article contains the full text of the retracted article as Supplementary Information.) here
Dr. Jackie Stone " So – if covid is a thrombotic event, ivermectin is a reperfusion drug.”
In addition to these effects, “The brain fog lifts, the feeling of impending doom lifts, the body pain, the systemic symptoms all start to go away, the headache goes away” she adds. The roof ( ceiling of clinic treatment room?) looked as if it was a wave pool but she told herself it was a visual side effect of ivermectin and thought, “Excellent! I’ve had enough [ivermectin]!”
I very recently read an article in NYT or WP ( can’t recollect) which was full of anecdotes about adverse effects of ivermectin, including deaths. There was no background information as to why the deaths could be due to ivermectin. Such negative reporting. Millions around the world survived covid, often without a flutter, thanks to ivermectin. I don’t know why international papers like these don’t follow international experience and report them. A successful medical practice is a world good, no matter where it came from them. The medical community anywhere cannot ignore them. At best seek more clarifications. The few adverse events could be due to self medicated overdose. I note (first time) that last week, there was this international Ivermectin day. How could a celebrated medicine like it could go wrong ? If the clinicians didn’t care to understand how exactly it could be safely and successfully used, the drug is not to be blamed. And this happens only in the western system of medicinal practice.
Well said Moro.
Is that in line with the so far knowledge that IVM is a 3CL Protease Inhibitor ? See Dr. Campbell youtube where he explains comparison study of IVM vs. Paxlovid. Both work as P.Inhib.
If that was the case, better protease inhibitors would have more effective results.
No antiviral has shown great value here.
I consider IVM as antiviral and - remember e.g. Papa Newguinea case where society was largely given (also) IVM doses. Then there is India were reports showed that IVM works well, small scale studies from IL etc... would you exclude IVM in your statement "No antiviral has shown great value here" ?
Thanks for Sharing Dr McMillan
I am surprised about this mechanism of IVM. My knowledge was (source: e.g. Dr. Campbell, youtube - that IVM works as a 3CL-Protease Inhibitor, i.e. IVM is inhibiting the replication of SARS CoV2. In a video he explains a study where IVM was tested against PAvloxid - both work sam
That may also be part of the benefit but this characteristic to inhibit PAK1 is huge.
Also explains some of the benefit with HCQ.
also concerning ivermectin-
- SARS-CoV-2 invades host cells via a novel route: CD147-spike protein - https://www.biorxiv.org/content/10.1101/2020.03.14.988345v1
- “CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis” - https://www.nature.com/articles/s41392-022-01230-5 "CD147 has been identified as a universal receptor for SARS-CoV-2 and its variants, which could initiate COVID-19-related cytokine storm."
- The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article
my note: evildoers who have taken over "Nature" can be relied upon, these days, to serve evil (The Editor-in-Chief therefore no longer has confidence in the reliability of this review article. None of the authors agree to this retraction. The online version of this article contains the full text of the retracted article as Supplementary Information.) here
https://static-content.springer.com/esm/art%3A10.1038%2Fs41429-021-00430-5/MediaObjects/41429_2021_430_MOESM1_ESM.pdf
"Level 19: Action on CD147 on the RBC
The SARS-CoV-2 does not internalize into the red blood cells but such attachments
can lead to clumping.
IVM binds to the S protein of the SARS-CoV-2 virus making it unavailable to bind
with CD147.
David E.Scheim et al. 2020 [65"
MY NOTE: KNOWN AND NOISED ABROAD IN 2020
discussed here on youtube "Discussion with Dr David Scheim about the effects of Vascular Occlusion during COVID."
HIBBERD HEALTH Jennifer Hibberd https://www.youtube.com/watch?v=4h2nO4wMRis
"The patient experience of ivermectin" re-profusion drug application of 100 mg dose of ivermection https://medicalupdateonline.com/2021/04/the-patient-experience-of-ivermectin/
Dr. Jackie Stone " So – if covid is a thrombotic event, ivermectin is a reperfusion drug.”
In addition to these effects, “The brain fog lifts, the feeling of impending doom lifts, the body pain, the systemic symptoms all start to go away, the headache goes away” she adds. The roof ( ceiling of clinic treatment room?) looked as if it was a wave pool but she told herself it was a visual side effect of ivermectin and thought, “Excellent! I’ve had enough [ivermectin]!”
We’ve treated hundreds of covid patients since the beginning of the pandemic. Ivermectin, HCQ and TMPRSS blocking agents. We’ve known for a long time now that it workers. Prohibition of these drugs was a crime against humanity. This evil must go away.
Vitamin D3 is far cheaper and less controversial than any other intervention - people need to get out in the sun and fresh air for covid and many other health reasons. The lockdowns could be considered a criminally negligent intervention when they prevented people going outside in the summer.
Doctors in many (lesser ?) parts of the world began rallying successfully against covid in 2021 during the delta wave applying better clinical understanding of the disease including early treatments. Ivermectin was one of their key weapons. In 2020 and in early 2021, the entire world followed western guidelines, no treatments in viral phase, with many people heading to hospitals with chocked lungs. Some doctors here and there saw it as inflammation, used arthritis drugs like Anakinra with some success. Chocked lungs was the cause for excessive deaths in that phase. It is unfortunate that not many doctors around the world could recall that in another condition of filariasis, chocked lungs were cleared with safe use of Ivermectin. This was one of its established use in some parts of the world. One must examine why sharp clinical thinking froze in that period everywhere. There were some successful patient level trials with Ivermectin as one of the drugs and there was some kind of field use too. But not until about mid 2021, did Ivermectin become a key medicine to contain this disease in large scale. When covid 19 is taught in medical schools in future generations, Ivermectin must be a key point.
Anti histamines are the most effective against the Omicrons, even where Ivermectin wouldn’t be fully adequate. Their primary mechanism here could be that of lysosomotropic, their chemical change in the lysosomes. Being Cationic Amphiphilic Drugs ( CADs), by virtue of their chemical structures, they pick up the protons (acidity) in the lysosomes to become cationic and deny any kind of RNA activity for the virus inside the cell. In fact, my guess is that these drugs, not just anti histamines but hundreds of drugs from many other indications sharing that nitrogen structure feature, will neutralise the active cationic segments of the virus spike protein outside the cell itself denying the route for its cell entry. The result, no viral build up, not enough viral load in those treated individuals for transmission in the neighbourhood and eventually no spread of the virus in society. Precisely the story in societies that switched full force to early treatments with these common drugs. In those treatments, Ivermectin is a handy help, as it provides additional mechanisms for anti viral work.
Ivermectin has off label anti viral and anti inflammatory properties. However, in the doses acceptable to humans ( as anti parasitic), these properties are only part effective. It can be made up with other groups like anti histamines. So, Ivermectin is best used as part of multi drug prescription. This is fine because viral respiratory infections are also traditionally treated with multiple products. So, Ivermectin has a role in covid management. The background needs to be well understood while being prescribed. Dr. Chetty used to mention how Ivermectin can be profitably used in the autoimmune phase of covid (with variants prior to Omicron, upto delta) to clear congested lungs of dead cellular matter, very similar to its established use in filarial pneumonia. He also mentioned about DCC ( Diethyl carbamazine citrate) being a better drug for that role. It would be nice if he can post his exact views on this subject in the comments box of this podcast. I haven’t heard any other physician talking about such a need.
Some real life feedback, non-scientific - a friend of mine reached out to me to get IVM for one of his buddies. The person (had covid post vaccination) in question had lost smell and taste for several months. The gentlemen consulted with various Dr, acupuncture and more. No luck. Surgery was proposed! After taking IVM for 5 days he stayed - smell and taste 80% back…
Omicrons’ less capability to cell entry and their ready susceptibility to anti histamines could be sides of the same coin. I don’t know if there is any reported research comparing the chemical structural features of the spike proteins of some of the Omicrons with the older variants like Wuhan, Alpha and Delta. I suspect Omicrons will have less number of active cationic spike segments than the predecessors. It means less propensity to lodge on the negative surfaced cell walls in preparation for cell entry. It also means easier work for anti histamines or similarly structured other anti virals. The earlier variants could have had more locking sites on the cell wall. It is like your shirt having only one button instead of the normal 5 buttons.
also concerning ivermectin-
- SARS-CoV-2 invades host cells via a novel route: CD147-spike protein - https://www.biorxiv.org/content/10.1101/2020.03.14.988345v1
- “CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis” - https://www.nature.com/articles/s41392-022-01230-5 "CD147 has been identified as a universal receptor for SARS-CoV-2 and its variants, which could initiate COVID-19-related cytokine storm."
- The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article
my note: evildoers who have taken over "Nature" can be relied upon, these days, to serve evil (The Editor-in-Chief therefore no longer has confidence in the reliability of this review article. None of the authors agree to this retraction. The online version of this article contains the full text of the retracted article as Supplementary Information.) here
https://static-content.springer.com/esm/art%3A10.1038%2Fs41429-021-00430-5/MediaObjects/41429_2021_430_MOESM1_ESM.pdf
"Level 19: Action on CD147 on the RBC
The SARS-CoV-2 does not internalize into the red blood cells but such attachments
can lead to clumping.
IVM binds to the S protein of the SARS-CoV-2 virus making it unavailable to bind
with CD147.
David E.Scheim et al. 2020 [65"
MY NOTE: KNOWN AND NOISED ABROAD IN 2020
discussed here on youtube "Discussion with Dr David Scheim about the effects of Vascular Occlusion during COVID."
HIBBERD HEALTH Jennifer Hibberd https://www.youtube.com/watch?v=4h2nO4wMRis
"The patient experience of ivermectin" re-profusion drug application of 100 mg dose of ivermection https://medicalupdateonline.com/2021/04/the-patient-experience-of-ivermectin/
Dr. Jackie Stone " So – if covid is a thrombotic event, ivermectin is a reperfusion drug.”
In addition to these effects, “The brain fog lifts, the feeling of impending doom lifts, the body pain, the systemic symptoms all start to go away, the headache goes away” she adds. The roof ( ceiling of clinic treatment room?) looked as if it was a wave pool but she told herself it was a visual side effect of ivermectin and thought, “Excellent! I’ve had enough [ivermectin]!”
Dr Mc Millan can you do a video on this so people can understand it please.
KEVIN MC KERNAN
https://twitter.com/Kevin_McKernan/status/1626056034442698753
Antibiotic resistant bacteria brought to your microbiome
SASHA LATYPOVA SUBSTACK
https://sashalatypova.substack.com/p/vials-of-pfizer-and-moderna-are-contaminated
ARCHIVED ⬇️
https://archive.md/2023.02.16-201647/https://sashalatypova.substack.com/p/vials-of-pfizer-and-moderna-are-contaminated