Hydroxychloroquine (HCQ) may turn out to be one of the most important drugs at this stage of the COVID-19 pandemic. This is through the effect of the drug on endosomes within cells. It must be made clear that from a scientific perspective, I was very upset when this remarkably versatile drug became caught up in a political storm. The politicisation of the situation ensured that scientific perspectives would be skewed and objectivity could be lost.
Very simple. Emergency Use Authorization which bypass safety studies could have no alternative treatment options. The Pelosi hammer that came down each time you mention early treatment options was to shutter the mass Vax Pfizer cash delivery system to the front of the line. Who studying this thinks any other way at this point. The fraud is laid bare for all to see who care to look. Keep up the hard work. The nexus is where law meets medecine. https://rumble.com/v1qc8zn-p-dr-nass.html
I am being careful. After this post I went to see my primary and we discussed it. She ordered a CT for my head and sinuses, so we can start nailing it down. She also referred me to see a EMT.
I have HCQ and have taken it prophylactically along with IVM since 2021. I've never been sick, never tested positive (after 30+ tests) and have had antibody plus T-Cell tests, all negative. So IF the virus "entered my sinuses" and has not left, then the theory might be correct.
My choice today was a) do I want to feel better (take the HCQ on my own) or... Do I want to prove "something" about omicron, and wait until the CT scans + come back and deal with my doctor about what to do.
I choose to go ahead and heal myself.. which is why I got the antiviral on my own.
In general, i am not clear why preventing the spread of SC2 variants is a goal at this point. The virus is endemic, it is continually spreading and re-infecting with small changes, just like the common cold. As living animals, it is natural and expected to be exposed often so that our immune systems keep up. It is precisely when we are not exposed to the small changes that we end up with a more severe effect as our immune system has more catching up to do.
On the other hand, for those who got injected with the mRNA products, their adaptive immune systems are primed and likely overriding their innate immune systems, creating an abundance of non-neutralizing infection-enhancing antibodies that, as Geert Vanden Bossche explains more aptly than i can, will inevitably (and soon) lead to catastrophic breakthrough infections on a mass scale that are deadly. He also says you cannot stop the spread, except with a massive application of neutralizing antiviral treatments that catches all the variants at once - not these silly trivalent "vaccines" that target last month's variants after they have already bypassed the innate immune system.
The problem with any antiviral drug against SC2 is that clinical trials may rather prove these drugs are ineffective than the opposite. This is because the viral loads of SC2 are the highest 1,8 days before the symptom onset. And the patients usually start antiviral course days after the symptoms – after prescription from the physician, when the viral loads are decreasing or there are even no replication competent viral particles – only viral debris. There are a lot of clinical trials with IVM which start on day 7 after symptoms, and in mild and moderate C19 these trials per definition can’t prove significant improvement. On day 7 and onwards IVM may prove benefits due to its immunomodulatory effect or due to avoidance of secondary infection only, which are PASC or other diagnoses, but C19. HCQ similarly on day 7 and onwards shall have no antiviral effect (vacuole pH elevation, ACE2 glycosylation prevention, etc.) only immunomodulatory (reduction of IL-1 release through inhibition of TLRs, for instance), which does not help in mild or moderate C19. And in case of severe C19 placebo/control group shall be subject to corticosteroids+antiviral drugs, which shall prove more effective than sole HCQ or IVM.
In summary: it is hard to design a clinical trial to prove HCQ or IVM are effective in case of C19. And it is easy to prove no effect by only changing control group definition or inclusion time.
I have written this before, but this box is an opportunity to reach more discerning and appropriate audience. The reason why the West discarded initial trials with HCQ, Ivermectin or Azithromycin, after declaring their performance as inadequate, is that these drugs were looked at as silver bullet, dedicated anti virals. This was clinically a wrong premise. It is common to treat respiratory infections with a combination of medicines, providing opportunities for multiple mechanisms. So these drugs should have been evaluated in combination with others like anti histamines. Many countries like India adopted this approach mid way in delta in 2021 and for Omicron in 2022. The results were telling and these molecules were star performers. The West’s premise was self defeating. As part anti virals, in combinations, these drugs would have made the job. For any new indications in future, this must be borne in mind. All these are multi therapeutics as well, often useful in such infections. Azithromycin is considered an anti viral too, by the same endosome mechanisms.
As a result of reading your article I realize that I have a persistent sinus infection that is either omicron or a bacteria. I went to see a pulmonologist for surgery clearance in Sept. and he diagnosed me with a bacterial sinus infection (though not through any testing, just asking me my symptoms), and gave me a course of antibiotics and steroids. This relieved it a bit, but its still there. I will now take a course of HCQ. After looking up the symptoms of paranasal sinuses, I have just about all of them.
Its unfortunate that Doctors are not allowing themselves to expand their understanding of Covid-19 infection manifestations.. and are trying to use old methods on a new pathology.
Like HCQ, there could be dozens, even hundreds of known drug molecules from many many different indications, with endosomes mechanisms of anti viral
activity. Read also lysosomotropic agents, cationic amphiphilic drugs (CAD). Particularly with basic nitrogen in their chemical structures, more specifically if the nitrogen is present as an amine. The criterion seems to be a molecule with a pKa above 7.5 (acid dissociation constant). Lot of work has been done on CADs ( a chemical structure based drug classification) and anti viral activity. Anti histamines, even Azithromycin are powerful therapeutics for covid precisely for this reason. I am a simple organic chemist ( a PhD from 1970s), not even a medicinal chemist by training or experience. I have seen the chemical structures of some 600 known drugs from different streams, with almost all of them with such features. I have also read that there are over 3000 drug molecules in use now and 80% of them contain Nitrogen in their chemical structure. Even if 50% of them have suitable structural features (of nitrogen) and chemical parameters like pKa, we have a stockpile of over 1000 drug molecules, potentially anti viral from their endosome mechanisms, that could be present in any decent high street pharmacy. What a prospect, sorely ignored in this pandemic ? I want your readers and viewers remain alive to this immense potential and prospect. Extensive repurposing studies during covid have also thrown up the prospect that many of these molecules have multiple capabilities. Like the anti biotic Azithromycin being a powerful anti viral, anti parasitic (malarial) too. Like anti histamines being anti viral too.
There was a retroactive study done - risk stratified - it kept 84% of high risk patients out of the hospital, and those that were hospitalized didn't need vents.
Yes, they would.
And already have.
Covid is ALL politics.
Very simple. Emergency Use Authorization which bypass safety studies could have no alternative treatment options. The Pelosi hammer that came down each time you mention early treatment options was to shutter the mass Vax Pfizer cash delivery system to the front of the line. Who studying this thinks any other way at this point. The fraud is laid bare for all to see who care to look. Keep up the hard work. The nexus is where law meets medecine. https://rumble.com/v1qc8zn-p-dr-nass.html
I am being careful. After this post I went to see my primary and we discussed it. She ordered a CT for my head and sinuses, so we can start nailing it down. She also referred me to see a EMT.
I have HCQ and have taken it prophylactically along with IVM since 2021. I've never been sick, never tested positive (after 30+ tests) and have had antibody plus T-Cell tests, all negative. So IF the virus "entered my sinuses" and has not left, then the theory might be correct.
My choice today was a) do I want to feel better (take the HCQ on my own) or... Do I want to prove "something" about omicron, and wait until the CT scans + come back and deal with my doctor about what to do.
I choose to go ahead and heal myself.. which is why I got the antiviral on my own.
I used it with Omicron, took it early and did fine. First day I had a little fever and small headache then from then on, I just had congestion.
I still have HCQ in my drawer, and it is available here in Burkina, where I live. IVM will be expired very shortly. Harder to get a hold of it.
In general, i am not clear why preventing the spread of SC2 variants is a goal at this point. The virus is endemic, it is continually spreading and re-infecting with small changes, just like the common cold. As living animals, it is natural and expected to be exposed often so that our immune systems keep up. It is precisely when we are not exposed to the small changes that we end up with a more severe effect as our immune system has more catching up to do.
On the other hand, for those who got injected with the mRNA products, their adaptive immune systems are primed and likely overriding their innate immune systems, creating an abundance of non-neutralizing infection-enhancing antibodies that, as Geert Vanden Bossche explains more aptly than i can, will inevitably (and soon) lead to catastrophic breakthrough infections on a mass scale that are deadly. He also says you cannot stop the spread, except with a massive application of neutralizing antiviral treatments that catches all the variants at once - not these silly trivalent "vaccines" that target last month's variants after they have already bypassed the innate immune system.
The problem with any antiviral drug against SC2 is that clinical trials may rather prove these drugs are ineffective than the opposite. This is because the viral loads of SC2 are the highest 1,8 days before the symptom onset. And the patients usually start antiviral course days after the symptoms – after prescription from the physician, when the viral loads are decreasing or there are even no replication competent viral particles – only viral debris. There are a lot of clinical trials with IVM which start on day 7 after symptoms, and in mild and moderate C19 these trials per definition can’t prove significant improvement. On day 7 and onwards IVM may prove benefits due to its immunomodulatory effect or due to avoidance of secondary infection only, which are PASC or other diagnoses, but C19. HCQ similarly on day 7 and onwards shall have no antiviral effect (vacuole pH elevation, ACE2 glycosylation prevention, etc.) only immunomodulatory (reduction of IL-1 release through inhibition of TLRs, for instance), which does not help in mild or moderate C19. And in case of severe C19 placebo/control group shall be subject to corticosteroids+antiviral drugs, which shall prove more effective than sole HCQ or IVM.
In summary: it is hard to design a clinical trial to prove HCQ or IVM are effective in case of C19. And it is easy to prove no effect by only changing control group definition or inclusion time.
I have written this before, but this box is an opportunity to reach more discerning and appropriate audience. The reason why the West discarded initial trials with HCQ, Ivermectin or Azithromycin, after declaring their performance as inadequate, is that these drugs were looked at as silver bullet, dedicated anti virals. This was clinically a wrong premise. It is common to treat respiratory infections with a combination of medicines, providing opportunities for multiple mechanisms. So these drugs should have been evaluated in combination with others like anti histamines. Many countries like India adopted this approach mid way in delta in 2021 and for Omicron in 2022. The results were telling and these molecules were star performers. The West’s premise was self defeating. As part anti virals, in combinations, these drugs would have made the job. For any new indications in future, this must be borne in mind. All these are multi therapeutics as well, often useful in such infections. Azithromycin is considered an anti viral too, by the same endosome mechanisms.
Of course they would. They do not care about lives only Pharma profits. Faux democracy.
Indeed thanks for Sharing Dr McMillan much appreciated 👍
As a result of reading your article I realize that I have a persistent sinus infection that is either omicron or a bacteria. I went to see a pulmonologist for surgery clearance in Sept. and he diagnosed me with a bacterial sinus infection (though not through any testing, just asking me my symptoms), and gave me a course of antibiotics and steroids. This relieved it a bit, but its still there. I will now take a course of HCQ. After looking up the symptoms of paranasal sinuses, I have just about all of them.
Its unfortunate that Doctors are not allowing themselves to expand their understanding of Covid-19 infection manifestations.. and are trying to use old methods on a new pathology.
BUT THAT'S WHY WE HAVE YOU!!!
Thank you!
Like HCQ, there could be dozens, even hundreds of known drug molecules from many many different indications, with endosomes mechanisms of anti viral
activity. Read also lysosomotropic agents, cationic amphiphilic drugs (CAD). Particularly with basic nitrogen in their chemical structures, more specifically if the nitrogen is present as an amine. The criterion seems to be a molecule with a pKa above 7.5 (acid dissociation constant). Lot of work has been done on CADs ( a chemical structure based drug classification) and anti viral activity. Anti histamines, even Azithromycin are powerful therapeutics for covid precisely for this reason. I am a simple organic chemist ( a PhD from 1970s), not even a medicinal chemist by training or experience. I have seen the chemical structures of some 600 known drugs from different streams, with almost all of them with such features. I have also read that there are over 3000 drug molecules in use now and 80% of them contain Nitrogen in their chemical structure. Even if 50% of them have suitable structural features (of nitrogen) and chemical parameters like pKa, we have a stockpile of over 1000 drug molecules, potentially anti viral from their endosome mechanisms, that could be present in any decent high street pharmacy. What a prospect, sorely ignored in this pandemic ? I want your readers and viewers remain alive to this immense potential and prospect. Extensive repurposing studies during covid have also thrown up the prospect that many of these molecules have multiple capabilities. Like the anti biotic Azithromycin being a powerful anti viral, anti parasitic (malarial) too. Like anti histamines being anti viral too.
There was a retroactive study done - risk stratified - it kept 84% of high risk patients out of the hospital, and those that were hospitalized didn't need vents.