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Bob L's avatar

My question is when a variant appears in somebody's body that is able to escape the protection in the lungs provided by the non-neutralizing antibodies, will that variant become dominant also in the upper respiratory? I imagine that new variant might simply migrate into the lungs and blood where older variants struggle to go, but the upper respiratory might continue to be dominated by older variants. Thus that infected person will mostly spread the older variants to other people even though his lungs and blood are infected with the new variant.

This seems to be a missing step in Geert's proof that I wish could be clarified for laypeople like me.

EDIT: I think my question is answered at the 27 minute mark in the video. Geert says non-neutralizing antibodies serve two purposes - viral clearance and protection in the lungs. The viral clearance is the new area of competition between variants, and that has the side effect of increasing virulence in the lungs.

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Mary's avatar

Looking forward to this.

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