The epidemiology of Omicron suggests there is a piece of the COVID-19 puzzle that is missing. Between 4% and 6% of people in the UK are infected with Omicron – how can this occur without achieving herd immunity in a few months? Whilst I’m not an epidemiologist, I would estimate that over 60% of the population would be infected within 2 months (based on a similar percentage being infected every 5 days), and thereafter infection levels would decline, rather than increase.
This is a good question. The vaccinated immune system may never develope a sufficient number of mucosal antibodies to rid the virus due to OAS.
Being jab free for over ten years now, I can say that I have not had to deal with a sinus infection for years and they were a chronic problem for me in the past.
Thank you for paying attention to NALT immunity in the URT. Please publish some posts about intramuscular vaccine induced Abs, T cells in the URT with particular focus to neutralizing capacity and half-life of vaccine induced immune cells there. Enlightening topic for the C19 pandemic.
With regard to the present post I have the following remarks:
- Nasal sinuses are not immunoprivileged tissues of mammalians. Typical immunoprivileged tissues of mammalians include the pregnant uterus, eye, brain, and testis. Therefore, virus does not hide there, while the viral particles may remain there for prolonged period of time;
- Even seroconverted individuals may get reinfected when exposed to high loads of pathogen. Without sanitation plagues would not have been stopped in Middle Ages. High viral loads of SARS-CoV-2 is hard to reduce without nasal/oral hygiene and ventilation while the virus can easily reside in multiple reservoirs: pets and livestock, for instance.
- Omicron BA.5 have managed to develop reliance on multiple cell surface proteins to ensure membrane fusion. While Delta was primary dependent on TMPRSS2, BA.5 uses C-type lectin, Adam10 or 17, etc, therefore BA.5 tissue tropisms is not limited to ACE2 dominant cell lines. This is serious concern that prolonged sub-optimal immune pressure may push the virus to immunoprivileged tissues. And with the respiratory virus only BBB protects brains from this risk.
This certainly chimes in with my anecdotal personal experience. During the spring and summer of 2020 I started suffering regularly recurring painful 'burning' sinus headache lasting one to two days ... all the way to August 2021 when I came down with covid proper (likely Delta). As I recovered from the virus my sinus episodes completely stopped. I wondered if this was due to my immune system, or the antiviral anti-covid protocol I was on, inadvertently clearing that lingering sinus issue.
Fast forward to late May this year when I started suffering blocked nasal passage. No pain this time, just constantly needing to clear /blow nose. Went on for nearly a month. I ascribed it to a vague 'allergy' and didn't think much of it... until I came down with covid again. Mild case this time, likely omicron, lasting a few days. As the fever and the coughing cleared... so did my nasal passage.
Great Information , However its even lagging behind what we are seeing out in the field. The new Ba4 and 5 are obsurved reinfections in less than 28 days. The ramification of this on the old folks is when they test positive and survive the ilness we have to be reall negligent to give them a 90 hiatus on testing whan 14 days is much more logical. We dont need more stelth entry into the SNF's
Sinusitis is a serious ailment due to its closeness to the brain. It must be treated, but it must also be diagnosed in the first place. Many a doc, in my experience, miss sinusitis in their rule out assessments. Leaving patients in a very vulnerable position.
Recent substack article by Dr. paul Alexander nasal-oral tx’s covid.
Since the initial presentations were mild, there was this tendency among people to skip initial medicinal care with Omicron. We could take this liberty with the age old common cold. Now it must be clear that in this age, early medicines are a must, right on symptoms, whether tested or not, tested positive or not. The protocol must be a combination of anti histamines, as pills, syrups and nasal drops, depending on the composition of symptoms. It can include Azithromycin also, as it is a part anti viral, as are most of these anti histamines. Only that way, we can ensure that there is no residual viral load present in nasal pathways including sinuses. The viral load should not be allowed to entrench itself. It is the cause for long covid also.
This is a good question. The vaccinated immune system may never develope a sufficient number of mucosal antibodies to rid the virus due to OAS.
Being jab free for over ten years now, I can say that I have not had to deal with a sinus infection for years and they were a chronic problem for me in the past.
Thank you for paying attention to NALT immunity in the URT. Please publish some posts about intramuscular vaccine induced Abs, T cells in the URT with particular focus to neutralizing capacity and half-life of vaccine induced immune cells there. Enlightening topic for the C19 pandemic.
With regard to the present post I have the following remarks:
- Nasal sinuses are not immunoprivileged tissues of mammalians. Typical immunoprivileged tissues of mammalians include the pregnant uterus, eye, brain, and testis. Therefore, virus does not hide there, while the viral particles may remain there for prolonged period of time;
- Even seroconverted individuals may get reinfected when exposed to high loads of pathogen. Without sanitation plagues would not have been stopped in Middle Ages. High viral loads of SARS-CoV-2 is hard to reduce without nasal/oral hygiene and ventilation while the virus can easily reside in multiple reservoirs: pets and livestock, for instance.
- Omicron BA.5 have managed to develop reliance on multiple cell surface proteins to ensure membrane fusion. While Delta was primary dependent on TMPRSS2, BA.5 uses C-type lectin, Adam10 or 17, etc, therefore BA.5 tissue tropisms is not limited to ACE2 dominant cell lines. This is serious concern that prolonged sub-optimal immune pressure may push the virus to immunoprivileged tissues. And with the respiratory virus only BBB protects brains from this risk.
This certainly chimes in with my anecdotal personal experience. During the spring and summer of 2020 I started suffering regularly recurring painful 'burning' sinus headache lasting one to two days ... all the way to August 2021 when I came down with covid proper (likely Delta). As I recovered from the virus my sinus episodes completely stopped. I wondered if this was due to my immune system, or the antiviral anti-covid protocol I was on, inadvertently clearing that lingering sinus issue.
Fast forward to late May this year when I started suffering blocked nasal passage. No pain this time, just constantly needing to clear /blow nose. Went on for nearly a month. I ascribed it to a vague 'allergy' and didn't think much of it... until I came down with covid again. Mild case this time, likely omicron, lasting a few days. As the fever and the coughing cleared... so did my nasal passage.
Great Information , However its even lagging behind what we are seeing out in the field. The new Ba4 and 5 are obsurved reinfections in less than 28 days. The ramification of this on the old folks is when they test positive and survive the ilness we have to be reall negligent to give them a 90 hiatus on testing whan 14 days is much more logical. We dont need more stelth entry into the SNF's
Lance
Good catch! Thanks for spreading knowledge and encouraging enquiry.
Sinusitis is a serious ailment due to its closeness to the brain. It must be treated, but it must also be diagnosed in the first place. Many a doc, in my experience, miss sinusitis in their rule out assessments. Leaving patients in a very vulnerable position.
Recent substack article by Dr. paul Alexander nasal-oral tx’s covid.
https://substack.com/redirect/2/eyJlIjoiaHR0cHM6Ly9wYWxleGFuZGVyLnN1YnN0YWNrLmNvbS9wL215LWZyaWVuZC14eHh4eC1jbGluaWNpYW4taGlzLXNoYXJpbmc_dG9rZW49ZXlKMWMyVnlYMmxrSWpvMU9ETXdNamd6Tnl3aWNHOXpkRjlwWkNJNk5qTXpPVGsyTURRc0ltbGhkQ0k2TVRZMU56VXdNRGN3T0N3aWFYTnpJam9pY0hWaUxUVTNPVE0xTmlJc0luTjFZaUk2SW5CdmMzUXRjbVZoWTNScGIyNGlmUS5BQ0ZwVTFhUk9ueHpNYlhFZUhYdEJmel9WY1oyQ3dkMGRBeTFYbG5aazNBIiwicCI6NjMzOTk2MDQsInMiOjU3OTM1NiwiZiI6dHJ1ZSwidSI6NTgzMDI4MzcsImlhdCI6MTY1NzUwMDcwOCwiaXNzIjoicHViLTAiLCJzdWIiOiJsaW5rLXJlZGlyZWN0In0.o_Xba50EQTHhvsvUehS049YxkkZtOOdIJR33S7Fmthg?
Thanks. I based it also on Dr Chetty's and FLCCA protocols, and what I could get my hands on at the time. I'll add yours to the list :)
Since the initial presentations were mild, there was this tendency among people to skip initial medicinal care with Omicron. We could take this liberty with the age old common cold. Now it must be clear that in this age, early medicines are a must, right on symptoms, whether tested or not, tested positive or not. The protocol must be a combination of anti histamines, as pills, syrups and nasal drops, depending on the composition of symptoms. It can include Azithromycin also, as it is a part anti viral, as are most of these anti histamines. Only that way, we can ensure that there is no residual viral load present in nasal pathways including sinuses. The viral load should not be allowed to entrench itself. It is the cause for long covid also.
my wife has a constant health problem with sinus after omicron infection. She is not vaccinated. What is the cure/therapy?
B
This would explain a lot in ppl with neurological long haul issues.