This is a good question. The vaccinated immune system may never develope a sufficient number of mucosal antibodies to rid the virus due to OAS.
Being jab free for over ten years now, I can say that I have not had to deal with a sinus infection for years and they were a chronic problem for me in the past.
Thank you for paying attention to NALT immunity in the URT. Please publish some posts about intramuscular vaccine induced Abs, T cells in the URT with particular focus to neutralizing capacity and half-life of vaccine induced immune cells there. Enlightening topic for the C19 pandemic.
With regard to the present post I have the following remarks:
- Nasal sinuses are not immunoprivileged tissues of mammalians. Typical immunoprivileged tissues of mammalians include the pregnant uterus, eye, brain, and testis. Therefore, virus does not hide there, while the viral particles may remain there for prolonged period of time;
- Even seroconverted individuals may get reinfected when exposed to high loads of pathogen. Without sanitation plagues would not have been stopped in Middle Ages. High viral loads of SARS-CoV-2 is hard to reduce without nasal/oral hygiene and ventilation while the virus can easily reside in multiple reservoirs: pets and livestock, for instance.
- Omicron BA.5 have managed to develop reliance on multiple cell surface proteins to ensure membrane fusion. While Delta was primary dependent on TMPRSS2, BA.5 uses C-type lectin, Adam10 or 17, etc, therefore BA.5 tissue tropisms is not limited to ACE2 dominant cell lines. This is serious concern that prolonged sub-optimal immune pressure may push the virus to immunoprivileged tissues. And with the respiratory virus only BBB protects brains from this risk.
You appear to know a lot about the variants, using a number of terms I'm not familiar with, like “tissue tropisms”. Can you please tell me what BBB is?
Also, have any of your fears been realised, like the pushing of the virus (presumably a descendant of those prevalent at the time you were writing) to immunoprivileged tissues?
There were no fears in my comment. The cause of the fear is a lack of information.
There were concerns expressed in my comment. Viral tropism in testis, endocrine tissues (pancreas, pituitary, adrenal gland), CNS, and eyes have been well documented.
This certainly chimes in with my anecdotal personal experience. During the spring and summer of 2020 I started suffering regularly recurring painful 'burning' sinus headache lasting one to two days ... all the way to August 2021 when I came down with covid proper (likely Delta). As I recovered from the virus my sinus episodes completely stopped. I wondered if this was due to my immune system, or the antiviral anti-covid protocol I was on, inadvertently clearing that lingering sinus issue.
Fast forward to late May this year when I started suffering blocked nasal passage. No pain this time, just constantly needing to clear /blow nose. Went on for nearly a month. I ascribed it to a vague 'allergy' and didn't think much of it... until I came down with covid again. Mild case this time, likely omicron, lasting a few days. As the fever and the coughing cleared... so did my nasal passage.
First time around: Ivermectin, high dose vitD, zinc, famotidine + h1 antihistamines (rotating cetirizine and loratidine, I believe), quercertin, honey, turmeric, nasal and throat rinses.
Thanks. Very useful info. Very well clinically conceived prescription. I am not a doctor, a retired organic chemist (PhD) from India, taken to reading medicinal chemistry as a personal interest in retirement. I followed stories about this disease from very beginning in 2020, including trials. In June 2021, at the height of delta wave everywhere, after hearing the historical first conversation between Dr. McMillan and Dr. Shankara Chetty and following my own assessment of the organic chemistry of many many common drugs, I scribbled a prescription ( didn’t need to use it). It is like this. For the virus stage day 1 to day 10, Ceftaroline, Diphenhydramine, Montelukast, Indomethacin, Oxymetazoline (nasal drops). I shared it personally with family and friends. With these, you will not go to hospital, will be up and working. From chemical structures, my feeling was that each one of them was anti viral too, in addition to their labelled role, needed for treatment. Azithromycin turned out to be a popular option. Levocetrizine could have been a substitute. Later in 2021 and in 2022 (omicron), I followed dozens of actual prescriptions from doctors. Even though individual names were different sometimes, the clinical package was identical. No one had to run after the Remdisivirs, Molnupiravirs and the like.
Great Information , However its even lagging behind what we are seeing out in the field. The new Ba4 and 5 are obsurved reinfections in less than 28 days. The ramification of this on the old folks is when they test positive and survive the ilness we have to be reall negligent to give them a 90 hiatus on testing whan 14 days is much more logical. We dont need more stelth entry into the SNF's
Sinusitis is a serious ailment due to its closeness to the brain. It must be treated, but it must also be diagnosed in the first place. Many a doc, in my experience, miss sinusitis in their rule out assessments. Leaving patients in a very vulnerable position.
Recent substack article by Dr. paul Alexander nasal-oral tx’s covid.
Since the initial presentations were mild, there was this tendency among people to skip initial medicinal care with Omicron. We could take this liberty with the age old common cold. Now it must be clear that in this age, early medicines are a must, right on symptoms, whether tested or not, tested positive or not. The protocol must be a combination of anti histamines, as pills, syrups and nasal drops, depending on the composition of symptoms. It can include Azithromycin also, as it is a part anti viral, as are most of these anti histamines. Only that way, we can ensure that there is no residual viral load present in nasal pathways including sinuses. The viral load should not be allowed to entrench itself. It is the cause for long covid also.
Considering that the shots were ready so fast, and rushed to market, and that SARS-Cov-2 itself contains a genome sequence patented by Moderna some years earlier, one might wonder if the virus bioengineering is the start of the extinction. However, since purebloods claim immunity to it, perhaps it is "only" an extinction of the "sheeple".
This is a good question. The vaccinated immune system may never develope a sufficient number of mucosal antibodies to rid the virus due to OAS.
Being jab free for over ten years now, I can say that I have not had to deal with a sinus infection for years and they were a chronic problem for me in the past.
Thank you for paying attention to NALT immunity in the URT. Please publish some posts about intramuscular vaccine induced Abs, T cells in the URT with particular focus to neutralizing capacity and half-life of vaccine induced immune cells there. Enlightening topic for the C19 pandemic.
With regard to the present post I have the following remarks:
- Nasal sinuses are not immunoprivileged tissues of mammalians. Typical immunoprivileged tissues of mammalians include the pregnant uterus, eye, brain, and testis. Therefore, virus does not hide there, while the viral particles may remain there for prolonged period of time;
- Even seroconverted individuals may get reinfected when exposed to high loads of pathogen. Without sanitation plagues would not have been stopped in Middle Ages. High viral loads of SARS-CoV-2 is hard to reduce without nasal/oral hygiene and ventilation while the virus can easily reside in multiple reservoirs: pets and livestock, for instance.
- Omicron BA.5 have managed to develop reliance on multiple cell surface proteins to ensure membrane fusion. While Delta was primary dependent on TMPRSS2, BA.5 uses C-type lectin, Adam10 or 17, etc, therefore BA.5 tissue tropisms is not limited to ACE2 dominant cell lines. This is serious concern that prolonged sub-optimal immune pressure may push the virus to immunoprivileged tissues. And with the respiratory virus only BBB protects brains from this risk.
You appear to know a lot about the variants, using a number of terms I'm not familiar with, like “tissue tropisms”. Can you please tell me what BBB is?
Also, have any of your fears been realised, like the pushing of the virus (presumably a descendant of those prevalent at the time you were writing) to immunoprivileged tissues?
BBB=blood–brain barrier
There were no fears in my comment. The cause of the fear is a lack of information.
There were concerns expressed in my comment. Viral tropism in testis, endocrine tissues (pancreas, pituitary, adrenal gland), CNS, and eyes have been well documented.
This certainly chimes in with my anecdotal personal experience. During the spring and summer of 2020 I started suffering regularly recurring painful 'burning' sinus headache lasting one to two days ... all the way to August 2021 when I came down with covid proper (likely Delta). As I recovered from the virus my sinus episodes completely stopped. I wondered if this was due to my immune system, or the antiviral anti-covid protocol I was on, inadvertently clearing that lingering sinus issue.
Fast forward to late May this year when I started suffering blocked nasal passage. No pain this time, just constantly needing to clear /blow nose. Went on for nearly a month. I ascribed it to a vague 'allergy' and didn't think much of it... until I came down with covid again. Mild case this time, likely omicron, lasting a few days. As the fever and the coughing cleared... so did my nasal passage.
What was the medicinal protocol you adopted through and through, on both occasions ? Exact details would be very useful. Please write back. Thanks
First time around: Ivermectin, high dose vitD, zinc, famotidine + h1 antihistamines (rotating cetirizine and loratidine, I believe), quercertin, honey, turmeric, nasal and throat rinses.
Also took azithromycin and hcq. The second time around I think all that minus azithro and nasal and throat rinses.
Thanks. Very useful info. Very well clinically conceived prescription. I am not a doctor, a retired organic chemist (PhD) from India, taken to reading medicinal chemistry as a personal interest in retirement. I followed stories about this disease from very beginning in 2020, including trials. In June 2021, at the height of delta wave everywhere, after hearing the historical first conversation between Dr. McMillan and Dr. Shankara Chetty and following my own assessment of the organic chemistry of many many common drugs, I scribbled a prescription ( didn’t need to use it). It is like this. For the virus stage day 1 to day 10, Ceftaroline, Diphenhydramine, Montelukast, Indomethacin, Oxymetazoline (nasal drops). I shared it personally with family and friends. With these, you will not go to hospital, will be up and working. From chemical structures, my feeling was that each one of them was anti viral too, in addition to their labelled role, needed for treatment. Azithromycin turned out to be a popular option. Levocetrizine could have been a substitute. Later in 2021 and in 2022 (omicron), I followed dozens of actual prescriptions from doctors. Even though individual names were different sometimes, the clinical package was identical. No one had to run after the Remdisivirs, Molnupiravirs and the like.
Great Information , However its even lagging behind what we are seeing out in the field. The new Ba4 and 5 are obsurved reinfections in less than 28 days. The ramification of this on the old folks is when they test positive and survive the ilness we have to be reall negligent to give them a 90 hiatus on testing whan 14 days is much more logical. We dont need more stelth entry into the SNF's
Lance
Good catch! Thanks for spreading knowledge and encouraging enquiry.
Sinusitis is a serious ailment due to its closeness to the brain. It must be treated, but it must also be diagnosed in the first place. Many a doc, in my experience, miss sinusitis in their rule out assessments. Leaving patients in a very vulnerable position.
Recent substack article by Dr. paul Alexander nasal-oral tx’s covid.
https://substack.com/redirect/2/eyJlIjoiaHR0cHM6Ly9wYWxleGFuZGVyLnN1YnN0YWNrLmNvbS9wL215LWZyaWVuZC14eHh4eC1jbGluaWNpYW4taGlzLXNoYXJpbmc_dG9rZW49ZXlKMWMyVnlYMmxrSWpvMU9ETXdNamd6Tnl3aWNHOXpkRjlwWkNJNk5qTXpPVGsyTURRc0ltbGhkQ0k2TVRZMU56VXdNRGN3T0N3aWFYTnpJam9pY0hWaUxUVTNPVE0xTmlJc0luTjFZaUk2SW5CdmMzUXRjbVZoWTNScGIyNGlmUS5BQ0ZwVTFhUk9ueHpNYlhFZUhYdEJmel9WY1oyQ3dkMGRBeTFYbG5aazNBIiwicCI6NjMzOTk2MDQsInMiOjU3OTM1NiwiZiI6dHJ1ZSwidSI6NTgzMDI4MzcsImlhdCI6MTY1NzUwMDcwOCwiaXNzIjoicHViLTAiLCJzdWIiOiJsaW5rLXJlZGlyZWN0In0.o_Xba50EQTHhvsvUehS049YxkkZtOOdIJR33S7Fmthg?
Thanks. I based it also on Dr Chetty's and FLCCA protocols, and what I could get my hands on at the time. I'll add yours to the list :)
Since the initial presentations were mild, there was this tendency among people to skip initial medicinal care with Omicron. We could take this liberty with the age old common cold. Now it must be clear that in this age, early medicines are a must, right on symptoms, whether tested or not, tested positive or not. The protocol must be a combination of anti histamines, as pills, syrups and nasal drops, depending on the composition of symptoms. It can include Azithromycin also, as it is a part anti viral, as are most of these anti histamines. Only that way, we can ensure that there is no residual viral load present in nasal pathways including sinuses. The viral load should not be allowed to entrench itself. It is the cause for long covid also.
my wife has a constant health problem with sinus after omicron infection. She is not vaccinated. What is the cure/therapy?
B
This would explain a lot in ppl with neurological long haul issues.
Considering that the shots were ready so fast, and rushed to market, and that SARS-Cov-2 itself contains a genome sequence patented by Moderna some years earlier, one might wonder if the virus bioengineering is the start of the extinction. However, since purebloods claim immunity to it, perhaps it is "only" an extinction of the "sheeple".
Explain in 2 or 3 paragraphs what the heck that's about? Thanks
I always take the view that if you can't explain it simply then you don't understand it yourself.
No, but Einstein could - and that's my point.