Very interesting. Thank you for the interview. Dr Robert Rennebohm, and Dr Philip McMillan will have to make another interview in the future because there are many, still unresolved questions regarding auto-immunity in pediatric patients with Covid-19. There are growing interest around a world about multisystem inflammatory syndrome in c…
Very interesting. Thank you for the interview. Dr Robert Rennebohm, and Dr Philip McMillan will have to make another interview in the future because there are many, still unresolved questions regarding auto-immunity in pediatric patients with Covid-19. There are growing interest around a world about multisystem inflammatory syndrome in children several days to weeks after resolution of the initial infection. One hypothesis is superantigenic characteristics of SARS-CoV-2 with regard to S protein binding to TCRs and hyperactivating T cell responses. The second hypothesis is zonulin-dependent loss of gut mucosal barrier that increases in gut permeability allowing SARS-CoV-2 antigens, including the superantigen-like motif of the spike protein, to traffic across mucosal barriers and into the bloodstream and cause massive inflammation and autoimmune responses. And this has been observed in children only.
Very interesting. Thank you for the interview. Dr Robert Rennebohm, and Dr Philip McMillan will have to make another interview in the future because there are many, still unresolved questions regarding auto-immunity in pediatric patients with Covid-19. There are growing interest around a world about multisystem inflammatory syndrome in children several days to weeks after resolution of the initial infection. One hypothesis is superantigenic characteristics of SARS-CoV-2 with regard to S protein binding to TCRs and hyperactivating T cell responses. The second hypothesis is zonulin-dependent loss of gut mucosal barrier that increases in gut permeability allowing SARS-CoV-2 antigens, including the superantigen-like motif of the spike protein, to traffic across mucosal barriers and into the bloodstream and cause massive inflammation and autoimmune responses. And this has been observed in children only.
Looking forward to see your joint efforts.