Potential COVID-19 Vaccine Autoimmunity leading to Menstrual Irregularities

Ignored for over 2 years

The issue has been raised on many occasions but sadly our scientific community is happy with no logical explanation for the change in pattern.

Menstruation is one of the most sensitive and visible patterns in the human body, and any unusual changes should be rigorously studied.

The menstrual cycle is a process that happens in a girl's or woman's body. It involves four main hormones: oestrogen, progesterone, luteinising hormone (LH), and follicle-stimulating hormone (FSH).

The menstrual cycle relies on the interaction of hormones such as oestrogen and progesterone, with the gradual increase of oestrogen preceding a surge in luteinising hormone (LH), which is essential for ovulation to occur.

The findings indicate that menorrhagia, oligomenorrhea, and polymenorrhea were the most common menstrual irregularities after vaccination. The findings also suggest that a relatively high proportion of women suffer from menstrual irregularities. Further longitudinal studies are needed to confirm the causal relationship between COVID-19 vaccination and menstrual irregularities.

Al Kadri, Hanan M., et al. "COVID-19 vaccination and menstrual disorders among women: Findings from a meta-analysis study." Journal of Infection and Public Health (2023).

In the image above, the crucial step for ovulation is the spike in luteinising hormone. In order for this to occur, it requires a consistent rise in oestrogen in the week prior to ovulation.

Anything that interferes with this carefully balanced process is likely to have an impact on the menstrual cycle.

Spike protein has been shown to bind with the oestrogen receptor alpha and could potentially trigger an autoimmune response after infection or vaccination.

“Postmortem experiments in lung tissues from SARS-CoV-2-infected hamsters and humans confirmed an increase in cytoplasmic ERα expression and its colocalization with S protein in alveolar macrophages. These findings describe the discovery and characterization of a novel S-ERα interaction, imply a role for S as an NRC, and are poised to advance knowledge of SARS-CoV-2 biology, COVID-19 pathology, and mechanisms of sex differences in the pathology of infectious disease.”
Solis, Oscar, et al. "The SARS-CoV-2 spike protein binds and modulates estrogen receptors." Science Advances 8.48 (2022): eadd4150.

These patterns were not observed with natural infection and it is possible that it is a unique occurrence with vaccination.

Based on the autoimmunity principle around the spike protein, any combination is likely to have a risk of creating autoantibodies.

If this was to happen after vaccination, these autoantibodies to oestrogen receptor alpha could block the action of oestrogen on the relevant cells.

Longer term impacts on fertility will need to be rigorously assessed.

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