Huge piece of research that is currently in the pre-print stage for this paper. Reached out to Maria Cristina Sacchi (Italy) when I was informed about the paper. She kindly shared the abstract but not the full paper.
Based on my research into COVID-19 autoimmunity, these results could have significant implications.
It suggests that when monitoring Health Care Workers (HCW’s) over a 12 month period, they identified increased levels of antinuclear antibodies (ANA).
Measurement of ANA’s are a routine part of screening for multiple autoimmune diseases, and there has been increased prevalence in the general population over the past 20 years. This quote was taken from a paper looking at the prevalence across the USA
The prevalence of ANA was 11.0% in 1988-1991, 11.5% in 1999-2004, and 15.9% in 2011-2012 (trend P<0.0001), which corresponds to 22, 27, and 41 million affected individuals, respectively.
Dinse, Gregg E., et al. "Increasing prevalence of antinuclear antibodies in the United States." Arthritis & Rheumatology 72.6 (2020): 1026-1035.
What impact does mRNA vaccines have on autoantibodies?
In this Italian study they looked at a cohort of 108 HCW’s following their antibody titres before vaccination, at three months and at 12 months after vaccination.
It showed that 20% of vaccine recipients who were negative for ANA’s became positive within 12 months of vaccination. Additionally, those HCW’s who were already positive showed increased antibody titre.
Compared to influenza vaccination which in general did not alter the percentage of healthy adults with positive autoantibodies.