If Not Severe COVID-19, then what is killing as many people?

This winter could be very difficult in highly vaccinated regions

Reviewing the latest data regarding BA 2.86, another Omicron variant. When will this variant soup end?

Lasrado, Ninaad, et al. "Neutralization escape by SARS-CoV-2 Omicron subvariant BA. 2.86." Vaccine (2023).

Global Transitions in major variants April 2023 to September 2023

On the above chart, BA2.86 remains only a fraction of the percentage but could be expected to rise further.

When immunity is primarily focused on the spike protein, as with most injectable vaccines, the ability of the virus to evade immunity increases.

Baseline Neutralising antibodies after Bivalent booster

It should be noted that the strongest response after vaccination was still to the original Wuhan variant, almost 50 times higher than the BA2.86 variant. It is no wonder that these Omicron variants continue to circulate

Six months after Bivalent booster and Covid infection

How is it possible to have an infection with such elevated antibody levels? It suggests that the primary antibody class may be IgG4, which are immune tolerant antibodies.

In this circumstance, the immune system becomes permissive to SARS-COV2 infection.

Worrying times ahead.

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