How do antihistamines work to prevent severe COVID-19?

This important observation was first done through Dr Shankara Chetty (South Africa) and executed successfully over the course of the pandemic, to prevent all deaths with COVID-19.

When I first heard him describe the success using antihistamines and high dose steroids, I immediately went back to the research to understand the primary mechanism.

This video is a summary of that interaction between macrophages and mast cells in severe COVID-19.

Science is often about observing what works and then finding the explanation as to the why.