Could COVID-19 vaccine hyperimmunity explain some immune complications?

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Discussion looking at valuable research from Israel last year into the lymph node response to vaccination.

Cohen, Dan, et al. "Hypermetabolic lymphadenopathy following administration of BNT162b2 mRNA Covid-19 vaccine: incidence assessed by [18F] FDG PET-CT and relevance to study interpretation." European Journal of Nuclear Medicine and Molecular Imaging 48.6 (2021): 1854-1863.

Questions to answer:

•Higher levels of immune-mediated complications with COVID vaccines vs other vaccines – why?

•Are younger people at higher risk of complications?

•Vaccine-induced long Covid – is this real?

•Is the current dose of vaccine optimal?

Areas to be covered:

•Basics of lymph circulation

•Lymph node anatomy

•Principles of mRNA vaccine induced immunity

•Lymphadenopathy adverse events

•PET scan grading of vaccine induced lymphadenopathy

•Perspectives on the research outcomes