Could COVID-19 vaccine hyperimmunity explain some immune complications?

Discussion looking at valuable research from Israel last year into the lymph node response to vaccination.

Cohen, Dan, et al. "Hypermetabolic lymphadenopathy following administration of BNT162b2 mRNA Covid-19 vaccine: incidence assessed by [18F] FDG PET-CT and relevance to study interpretation." European Journal of Nuclear Medicine and Molecular Imaging 48.6 (2021): 1854-1863.

Questions to answer:

•Higher levels of immune-mediated complications with COVID vaccines vs other vaccines – why?

•Are younger people at higher risk of complications?

•Vaccine-induced long Covid – is this real?

•Is the current dose of vaccine optimal?

Areas to be covered:

•Basics of lymph circulation

•Lymph node anatomy

•Principles of mRNA vaccine induced immunity

•Lymphadenopathy adverse events

•PET scan grading of vaccine induced lymphadenopathy

•Perspectives on the research outcomes